Opioids SR-17018 Is the future of opioid detox medication. Painless easy cheat to avoid withdrawal that is too good to be true, but it is legit and real.

[Mycophile]

It dosent get much safer than kratom really.
How many years are u using and what quantities?

I'm not talking about Kratom's safety, I'm talking about SR-17018. Yes, Kratom is safe, but if I'm on it all the time eventually not only does it become less effective, but also, I just have a feeling that if I were to give in to literally using every day for a year that the WD would end up being much worse in the end than coming off like once a month for a month now. Plus, I do BJJ and martial arts and it's not good to train while on Kratom because you could injure yourself more easily without being aware of it due to the pain killing properties and it lowers testosterone and libido and I need frequent periods off of it to be at my best, but I also need frequent periods on it to...also be at my best in other ways.

I've used on and off for about 11 years. I got into OPMS black which I shouldn't because it ruins plain leaf, but when I reset my tolerance usually doses of 3 grams of plain leaf are good.

I don't really get why you don't see that it's SR-17018's safety I'm asking about and not Kratom's. It's a lifestyle thing. I can't be on Kratom all the time. It's just not good for my life, but it's also not good for me to not have the option of using it regularly. If I could choose I'd be on it like 65% of the time. I'd probably do like 1 month on, 2 weeks off cycles, or sometimes even 1 month on and 1 month off. But that isn't convenient at all constantly going through WD and having to work while not having slept much. Otherwise, if on vacation, then the WDs are very easy to get through cold turkey. I want to be able to use Kratom as an as-needed medication without ever having to worry about WDs, but the chances of that ever happening are slim to none. It all has to do with fitting it into my lifestyle in just the right way that most users on this forum probably don't think or care about...no offense to any of you, I'm just different in what I want out of it.

 

[Tetrapharmakos]

I mentioned this very early in the discussion. It's entirely possible for a person to stop using opioids. It's the fact that we KNOW from studies that it's relapse that is the issue. So I asked if the stuff would work equally well if used a second time. Nobody knows.

Well there isn't any reason to suggest SR-17018 would work any differently when using it to detox more than once.

But there are user reports from those who claim to have successfully and painlessly detoxed several times via SR-17018 so I tend to think the truth of it is if someone has detoxed using SR-17018 it will most likely work just as well for detox again if needed.

I have not used SR-17018 to detox more than once or know anyone else who has, but over the past year, I have helped several friends and acquaintances acquire SR-17018 and it has helped all of them detox with ease off of a variety of different opiates.

I might make another post here soon to share what I've learned along the way on how to use SR-17 the most effectively for detox.

The stuff really does have a tonne of potential.

 

[vision conquest]

Well there isn't any reason to suggest SR-17018 would work any differently when using it to detox more than once.

But there are user reports from those who claim to have successfully and painlessly detoxed several times via SR-17018 so I tend to think the truth of it is if someone has detoxed using SR-17018 it will most likely work just as well for detox again if needed.

I have not used SR-17018 to detox more than once or know anyone else who has, but over the past year, I have helped several friends and acquaintances acquire SR-17018 and it has helped all of them detox with ease off of a variety of different opiates.

I might make another post here soon to share what I've learned along the way on how to use SR-17 the most effectively for detox.

The stuff really does have a tonne of potential.

If you do please tag me man.

I know you have already given me some great info and I am very greatful but I am interested in knowing as much as possible about this compound.

I am in the process of attempting to acquire some but living in the land down under doesn't make it easy.

Unfortunately I doubt big pharma will be getting behind something like this, they would much prefer someone be on methadone, or one of the various forms of buprenorphine...they seem to love that one, all the new forms coming out.

 

[Allylbenzene]

...there are user reports from those who claim to have successfully and painlessly detoxed several times via SR-17018 so I tend to think the truth of it is if someone has detoxed using SR-17018 it will most likely work just as well for detox again if needed.

SR-17018 sounds great for initial cessation but doesn't seem suitable for preventing relapse, considering the people who report using it several times. They were successfully able to detox using SR-17018 but at some point chose to reuse. There's a few reasons why SR-17018 doesn't ensure long-term recovery (including TLR4 as mentioned in earlier posts).

I wrote this practical overview which addresses everything missing from SR-17018 (and methadone, buprenorphine, proglumide, suboxone) with a focus on long-term recovery & preventing relapse. Zero experimental or expensive items used, it's 100% OTC.

It'll do the job even without SR-17018 which avoids the hassle of trying to source it.

 

[Mycophile]

SR-17018 sounds great for initial cessation but doesn't seem suitable for preventing relapse, considering the people who report using it several times. They had the will to detox and used SR-17018 to achieve this but at some point chose to reuse. There's a few reasons why SR-17018 doesn't ensure long-term recovery (including TLR4 as mentioned in earlier posts).

I wrote this practical overview which addresses everything missing from SR-17018 (and methadone, buprenorphine, proglumide, suboxone) with a focus on long-term recovery & preventing relapse. Zero experimental or expensive items used, it's 100% OTC.

It'll do the job even without SR-17018.

So you are actually saying using this combo really means you won't have much, if any WD from opioids, including Kratom?

Have you actually used it for WD? Do you know others who have? A

 

[4DQSAR]

@Mycophile - I've posted links to all the extant papers CC SR-17018 twice. In a threads devoted to the stuff. I honestly cannot recall which ones so it's no easier for me to find than you. There was also a primate study and that was the one that suggested at least some amount of tolerance and dependence still occurs. But again, while primates are certainly closer to man than mice are, the two things are not the same.

I think what it more likely suggests is that SR-17018 is still capable of resulting in psychological addiction. Here on BL a couple of case reports mentioned that as an experiment, people took larger doses than were strictly required to manage AWS and in both cases they reported the typical psychoactive effects one would expect from an opioid. The primate study allowed unlimited consumption and a caged primate WILL suffer depression, anxiety and generally the mental health issues that make any form of mental escape desirable.

That's always been my point. Two decades helping out at Lifeline Publications means I'm aware that most people who truly wish to stop using opioids can do so. In the UK we tended to use methadone until a client got down to 10mg/day and then swap to dihydrocodeine and reduce that. It was the fact that so many people would come back for more help, some after decades of abstainance. Clearly not due to post-AWS but because in crisis, they self-medicated which is only human.

If memory serves, the human trial was to compare SR-17018 with oxycodone as an analgesia. The result was that it isn't a particularly good analgesic and further human studies (as an analgesic) were abandoned (as far as I know). For a while there has been several cases in which people have argued that biased ligands may actually be acting as partial or low efficacy ligands. I don't think that detail significant to most people. I think it was also compared to buprenorphine (used as intended i.e. reduced over 7-14 days) and was of similar utility.

I'm just trying to remember the overview of each paper from memory. So forgive me if I am in error.

 

[Allylbenzene]

I'm not in quite the same position since I do not take oxycodone for fun.

I'm well aware of this!

I take a methionine supplement as even just taking two tablets containing 500mg of paracetamol for a long time isn't really a good plan.

I just read up on how methionine mitigates the glutathione-depletion issue.

I went to the damned pharmacy yesterday and got plain ibuprofen I occassionaly use for back pain and forgot to ask for aspirin.

I always thought the pro-endocannabinoid aspect of paracetamol & ibuprofen was interesting.

 

[Allylbenzene]

I rarely touch ANYTHING I'm not prescribed

How inclusive is this? Does it include herbs & spices with analgesic qualities?

 

[Allylbenzene]

Well I had in mind something like you find in tescos/asda/sainsburies in the herbs & spices section. Here we find a range of herbal medicines with reasonable safety profiles. The herbal tea section is equally elaborate albeit stupidly expensive.

Or alternatively, a "single-ingredient" botanical item such as a volatile extract of myrrh (Commiphora myrrha) produced by steam distillation. There are a few reputable UK-based vendors who have been around for 30+ years. They always provide a GCMS for each batch.

I used the example of myrrh as it contains at least 1 COX2 inhibitor, at least 3 opioidergic analgesics and positively modulates TLR4 (ref), but there are dozens of other 'common' botanicals with similar qualities (I'm not referring to kratom/poppy).

Commiphora myrrh: a phytochemical and pharmacological update

...pharmacological action of Commiphora myrrh. It has been used traditionally for treating wounds, mouth ulcers, aches, fractures, stomach disorders, microbial infections, and inflammatory diseases.
...
Research has shown that it exerts various biological activities such as anti-inflammatory, antioxidant, anti-microbial, neuroprotective, anti-diabetic, anti-cancer, analgesic...

— https://doi.org/10.1007/s00210-022-02325-0

 

[4DQSAR]

Well there isn't any reason to suggest SR-17018 would work any differently when using it to detox more than once.

Science is based on skepticism.

Presumtion is the mother of all f*ckups.

 

[Allylbenzene]

So you are actually saying using this combo really means you won't have much, if any WD from opioids, including Kratom?

It's designed to minimise withdrawals in ways which most opioid-recovery combos don't achieve. It also addresses the relevant (underlying) things to prevent relapse (at least in the physical sense).

Have you actually used it for WD?

Not for wd but I've used the items for other purposes, including the reduction of tolerances.

Do you know others who have?

Others have yes so I'm told. Note - based on your other posts your scenario is quite unique so needs to be addressed carefully.

 

[Mycophile]

It's designed to minimise withdrawals in ways which most opioid-recovery combos don't achieve. It also addresses the relevant (underlying) things to prevent relapse (at least in the physical sense).


Not for wd but I've used the items for other purposes, including the reduction of tolerances.


Others have yes so I'm told. Note - based on your other posts your scenario is quite unique so needs to be addressed carefully.

I'm not quite sure what you mean by this. Is it that I feel like I'd like to be able to use Kratom very sporadically on and off without having to deal with withdrawal (which might not be possible)? Could you please expand on this?

Cause I'm wondering if I could use your combo to do the kind of thing I'd like to do with Kratom where I'd say, be on it for one month, then off it for the following month or the following 2 weeks, back on for 3 weeks, etc.

 

[cnnka]

IMO because it’s kratom it’s natural and it seems pretty safe it’s just better to use just kratom and not SR it’s a RC we don’t know it’s side effects and it’s long term effects.
So better stay at your schedule, if you can’t stop using it but want to, either go on a low enough dosage to avoid the WD’s for your “off time” or just cold turkey everytime if you can’t stop using handle it and worth it.
Weaning off a lighter drug with a stronger one and unknown dosent seem smart , it’s not like you’re ruining your life with heroin etc.
also you talked about “cycling” kratom what about if you do let’s say 1-2 weeks on 2 weeks off I mean enough ON time that would not cause WD’s when you stop it.

 

[Mycophile]

IMO because it’s kratom it’s natural and it seems pretty safe it’s just better to use just kratom and not SR it’s a RC we don’t know it’s side effects and it’s long term effects.
So better stay at your schedule, if you can’t stop using it but want to, either go on a low enough dosage to avoid the WD’s for your “off time” or just cold turkey everytime if you can’t stop using handle it and worth it.
Weaning off a lighter drug with a stronger one and unknown dosent seem smart , it’s not like you’re ruining your life with heroin etc.
also you talked about “cycling” kratom what about if you do let’s say 1-2 weeks on 2 weeks off I mean enough ON time that would not cause WD’s when you stop it.

If I even take Kratom 3 days in a row I'm getting WDs, and they'll last for 7-10 days, so that doesn't work. I get your point about thinking it's not worth the risks of taking SR-17018, but I'll have to consider that myself.

All I can really do for my off periods that would be different would be very slowly tapering so that I wouldn't really have all that much WD. I'll admit I haven't tried really hard at doing that, but I have tried here and there, and I usually just end up taking more. Cold turkey works better because the WDs just last so damn long that I want them over with, but then that really interferes with life and working cause it gives me insomnia.

I could try to force myself to take it only 1 day a week, maybe 2 max. I have naltrexone so I could use it for that, but it still requires willpower. I'd prefer to be on Kratom all the time but I start to really feel the negatives like the lowering of testosterone and I just know it's not great. There's probably no other real answer besides what I've already been doing which is enjoying it for a while, forcing myself to cold turkey, then stopping for a while, but it really just makes it so I can't use it to improve my life in the way I know I could if it were only like as addictive as weed or something like that.

 

[4DQSAR]

@Mycophile - I don't know where you are based but I previously mentioned that two biased opioids are on the market. One in the US, the other in China. Oliceridine (Olinvyk™) & tegileridine (Aisute™/艾苏特). I have no idea what if any legal controls surround their sale but both are licenced so at least will have been through the extensive safety testing required to gain approval i.e. get that licence.

Just a thought.

Obviously UK law means I can't even get kratom but most people seem able to taper their use, although I freely admit, this takes time.

 

[cnnka]

If I even take Kratom 3 days in a row I'm getting WDs, and they'll last for 7-10 days, so that doesn't work. I get your point about thinking it's not worth the risks of taking SR-17018, but I'll have to consider that myself.

All I can really do for my off periods that would be different would be very slowly tapering so that I wouldn't really have all that much WD. I'll admit I haven't tried really hard at doing that, but I have tried here and there, and I usually just end up taking more. Cold turkey works better because the WDs just last so damn long that I want them over with, but then that really interferes with life and working cause it gives me insomnia.

I could try to force myself to take it only 1 day a week, maybe 2 max. I have naltrexone so I could use it for that, but it still requires willpower. I'd prefer to be on Kratom all the time but I start to really feel the negatives like the lowering of testosterone and I just know it's not great. There's probably no other real answer besides what I've already been doing which is enjoying it for a while, forcing myself to cold turkey, then stopping for a while, but it really just makes it so I can't use it to improve my life in the way I know I could if it were only like as addictive as weed or something like that.

I understand it, you’re kind of stuck in that loop. When I was taking kratom, I’d take my night dose and by the morning I’d already wake up in WDs.

From my perspective, you have two choices. One is to stop it once and for all and either just raw dog life or find another substance that’s less addictive, like weed (a medical strain or whatever works for you).

The other option is to come to terms with it and keep a steady dosage that doesn’t interfere with your life but it won’t give you all the benefits. That’s the thing with all substances: at first you get all the advantages (analgesia, mood boost, social lubrication, etc.), but after a while they fade.
So if you can come to terms with keeping a steady low dose, you’ll probably keep something like the analgesia, but lose the mood boost and the rest. I don’t think there’s really an in-between with it.

As for testosterone concerns, I get it. I see it all the time with friends who use opioids low testosterone, low sex drive, etc. I’m on TRT, so I don’t really get those side effects anymore. If you’re at the right age, it might be something to consider.
I’m a bit hesitant to recommend this, but I used to be dependent on kratom too waking up in WDs every morning and it also got to the point where it felt gross and I couldn’t even get it down. I stopped for almost a year, and now I use 7-OH. It’s a lot more potent and has most of the benefits of kratom (even more, honestly), without most of the downsides except for testosterone.

I take breaks from it usually 2–3 days off every week. I haven’t noticed any withdrawals with it, not sure why, maybe because of its short half-life. I also don’t escalate the dose. I take around 2.5 to 10 mg max, usually around 7.5 mg, and I feel good there.
I think I have a relatively healthy relationship with it. Still, I’m a bit hesitant to recommend it because of all the horror stories around it but if it works for me, maybe it could work for someone else.

 

[4DQSAR]

Be aware that one known issue with SR-17018 is it's unreliable pharmokinetics. While it's always a good idea to reseach ANYTHING you are considering consuming, but be aware that on social media platforms discussants describe highly variable dosing requirements between individuals. A critical safety concern raised across multiple discussions is the risk of fatal overdose if individuals return to opioid use after their tolerance has been reduced by SR-17018. There appears to have been fatalities among people who resumed consumption of other 'classic' opioids after their tolerance has been lowered.

https://sci-hub.st/10.3390/molecules26154509

Sci-Hub. Comparison of morphine, oxycodone and the biased MOR agonist SR-17018 for tolerance and efficacy in mouse models of pain / Neuropharmacology, 2021

Sci-Net: Effects of a highly G Protein-Biased Mu Opioid Receptor Agonist, SR-17018, in Non-human Primates

Sci-Net: G Protein-Biased Mu Opioid Receptor Agonist SR-17018 Has Low In Vivo Efficacy In Non-Human Primates

Sci-Hub. Molecular Modeling of µ Opioid Receptor Ligands with Various Functional Properties: PZM21, SR-17018, Morphine, and Fentanyl—Simulated Interaction Patterns Confronted with Experimental Data / Molecules, 2020

Sci-Net: Opioid Analgesics: Rise and Fall of Ligand Biased Signaling and Future Perspectives in the Quest for the Holy Grail

There are a lot of recent academic papers on this compound, above is just a reasonable cross-section. I am unaware of any human (cohort) trial, that animal models cannot directly be compared with a human trial but of the above, the primate trial is probably the closest to a human trial. That said, proceed with caution.

lAI-generated summeries almost certainly do not use paywalled academic papers. I understand that most people have different but equally valid skill-sets. One of my few skillsets is finding and reading academic papers. If there is a specific aspect not covered that people would like to read, I will find the appropriate academic papers. If someone would like more papers and limit an AI generated summery to academic papers, I'm find with that.

I declare I have no conflict of interest. I am not nor never have been employed, consulted, paid or otherwise recieved recompense from any party involved in the production, distribucion, promotion or sales of any opioid.

 

[Allylbenzene]

Be aware that one known issue with SR-17018 is it's unreliable pharmokinetics. While it's always a good idea to reseach ANYTHING you are considering consuming

For old-fashioned people like me who still use google search, this one covers reddit for SR-17018 issues:

site:reddit.com +"SR-17018" +"problem"​

 

[4DQSAR]

Well, providing as many sources as possible is always my goal. The hierarchy of evidence means I will always try to find the best quality of evidence.

Evidence hierarchy graphic

Image Evidence hierarchy graphic hosted in Freeimage.host

freeimage.host

Case studies certainly ARE considered evidence. But since Reddit users typically just report on what they consider important, it isn't possible to consider multiple posts as a cohort study. Weight, height, medical history, ethnicity (as genetic differences can matter) and so on are typically not included.

I also have doubts about the autenticity of at least some of those entitely favourable reports in which not a single side-effect, or negative review. Specifically that some of the testimionals concern dezocine. The only nation on the planet where dezocine has been prescribed in the last fifteen years is China. Being a largely unmoderated forum, we have no way of knowing which if any of those glowing testimonials are real or are simply an ad campaign. I'm not asserting that this is the case, only that we have no way of knowing. So, as always, the scientific method is based on skepticism.

I know it's harsh but survivorship bias is a thing. I don't mean a person has do die, only that they experienced problems that they weren't comfortable sharing. It's been noted that SR-17018 has the potential risk of lowering a users tolerance only for them to OD if they then continue to dabble with 'classic' opioids. In an A&E (ER) situation, an OD is most unlikely to detect if SR-17018 contributed to that outcome and a patient is unlikely to disclose their use of a research ligand. As far as I know, outside the UK SR-17018 is not explicitly controlled, yet a clinician is unlikely to know that.

IF people do choose to consume the ligand, it IS sold as a research chemical. So buying from someone who at least provides a CoA and more importantly has a reputation to lose means they may charge more, but at least the buyer can be fairly certain the product is as described.

Again, I did ask if anyone had tried mixing the stuff with classic opioids but it seems (at least among BLers), either nobody had tried it or at least nobody had posted about it. I can see situations where a person might not want to admit to mixing two or more ligands, if only because they feel ashamed. I don't think anyone should ever feel shamed for self-medicating. But sadly, we still live in a world where some people are too judgemental.

 

[Josephine_Morphine]

Works orally, and won't destroy you tooth enamel. I fucking HATE it that I'm on Suboxone, what's it like to transition from bupe. to SR 01718? Only on Subs because I could not resist the 7OH train