Opioids SR-17018 Is the future of opioid detox medication. Painless easy cheat to avoid withdrawal that is too good to be true, but it is legit and real.

[Tetrapharmakos]

SR-17018 is an opioid research chemical that is unique in that it does not target "B-arrestin" like other opiates, rather it targets G-Protein. I'll be honest, I don't really know what that means, but if you do there are a few research papers you can find on this substance on google.

What I do know is that taking SR-17018 for a couple weeks allows you to stop taking any opiates without experiencing withdrawal. In those couple weeks of taking it, it will reset your tolerance back down to near zero. So much so, that there is some serious danger in using opiates after taking SR, and many have claimed there have been overdoses due to not realizing how sensitive they had become to opiates due to takin SR-17018.

I was hooked on opiates for 5 years pretty well non-stop. Tried all kinds of things to quit. I always, always failed to get through detox due to the crazy anxiety that I just could not exist with... time always seemed to come to a halt and one day was an entire lifetime of agony.

So after all of the countless detox attempts, methods, tricks, supplements, drugs, etc. I have tried to help detox off opiates, I did not believe SR-17018 was the painless cheat-code for detoxing that it was rumored to be. Even after i bought it I didn't believe it. Even after I started taking it, and it was indeed at-least preventing me from going into withdrawal while I used it.

After a few weeks using SR when I eventually stopped taking it, I was waiting to feel those withdrawal symptoms coming on at any moment. But they just never came. I really do believe this substance is the future of getting people through detox. The pharmaceutical companies will do everything they can to stop that so they can continue to sell as many people as possible suboxone pills or methadone for the rest of their lives, rather than a painless detox cure that only takes a few weeks and less than half a dozen grams. But it will get there eventually.

I'm just making this post to help spread the word. It's a little tricky to get this substance at times, there aren't too many batches of it being made in the labs in China where RCs usually come from. The more people who know about this, who are discussing it, etc. The better.

 

[dopamimetic]

Does the SR-17018 come with any psychoactivity? Do you feel something from it?

I had a similar experience with high dosed memantine, it allowed me to withdrew high dose morphine without much misery but there was still tolerance, when I did some morphine 2 months later I felt miserable on the day after.

 

[opiandy]

What is the recommended dose?

 

[Quasimoto]

SR-17018 is an opioid research chemical that is unique in that it does not target "B-arrestin" like other opiates, rather it targets G-Protein. I'll be honest, I don't really know what that means,

For reference, this is similar to kratom alkaloids. They are heavily g-protein biased and do not effect b-arrestin. This is why they do not cause respiratory depression, and are less euphoric than other opioids.

 

[jaycat420]

Thank u for the heads up

 

[4DQSAR]

I say this with a sincere lack of certainty but didn't later research suggest that rather than being a biased ligand, SR-17018 was, rather, a low efficacy ligand? I'm almost sure I read a later paper that suggested that being the case.

After all, brophine has turned up on the black market and I'm unclear if the researchers found it to be the LEAST biased when in fact it simply has the highest efficacy of the series.

CC brorphine - I've certainly come across patents in which that chiral methyl side-chain is resolved and the two enantiomers have different activities. In fact, I think the patent was actually trying to find NOP ligands. Uncertain if NOP affinity was covered by that original research.

Don't get me wrong, nobody would be more pleased than me if it turns out there is a new medicine that allows people to bypass the physical dependence to opioids. Obviously psychological addiction is a seperate issue.

 

[Kellsee]

Those first two paragraphs hit me so hard
and tore me all up. That would be my biggest dream come true!!!! To reset my receptors!?! To never need them!?!? A painless detox from opiates without withdrawal!?!?

I feel like I’ve been on trial my entire life. I hope this really becomes possible

 

[notsmokeymcpot42088]

Sounded great and I even saw it on a menu --- also sounded too good to be true right off the bat. Whats the deal with Methiodone? Supposably similar potency to methadone but I would like to hear some people that aren't pushing it talk lol.

 

[4DQSAR]

Sounded great and I even saw it on a menu --- also sounded too good to be true right off the bat. Whats the deal with Methiodone? Supposably similar potency to methadone but I would like to hear some people that aren't pushing it talk lol.

IC-26?

It's interesting that researchers found significnaly different activity between test subjects... but that's true of methadone itself. I've seen other classes of opioid in which an ethyl ketone was replaced with an ethylsulfonyl moiety (pethidine analogues) so it's likely active, but raecemic methadone isn't actually as potent as people think. It's the long duration that's important.

IF IC-26 is as good as vendors claim, surely the logical thing would for them to make the ethylsulfonyl analogs of dipipanone or phenadoxone. Both of those are considered more desirable than methadone.

Actually, there is another very obvious hole in the legal control of opioids. Not sure why it hasn't been spotted but it can be synthesized in a single step in high yields from commercially avilable precursors and is significnatly more potent than IC-26... so my GUESS is that someone just read the Wikipedia article, checked legal status and went with it. Becuase there are stronger/cheaper/better things... but they are obscure.

 

[notsmokeymcpot42088]

You are over my head but I appreciate it. IC-26 = Methiodone I gather... (My elementary teacher taught me about context clues) lol Idk it says SKU # jk lol

That sounds about right (If I am even correct about them being the same ppl, menu is the same) they are willing to push the line with stupid strong semi legal opis (A-Ft @ one point). I believe they have 3-desoxy-mdpv just because those last 4 letters make fools buy.

Very cryptic last few sentences that give me a small bit of hope for the future! In the US (things aren't going great im sure you heard) and would like to exercise any freedoms I may have before things get much worse -- Dude is already talking about cutting funding to rehabs etc (Would sub clinics fall under that? Probably) so having something in stock with a long duration that isn't so/as tempting to run through all of it sounds like a solid strategic move for the future. (Hopefully just for US)

I will say this as tough as the clonazolam journey was --- Super nice not to worry about that doc apt like my life depended on it. (as it kinda does). Knowing dude has full subjectivity to just say 'end of ride' at a whim. I literally felt "More free" that will make sense to my long term script ppl.

*Hell if I am gunna be old in real pain and counting on "Doctors" sorry if the quotes piss you off. Hell if I will be relying on middle men in my old age. (there offense gone)

 

[4DQSAR]

It's interesting that researchers even resolved the two enantiomers of the drug to prove that like methadone, the (S) enantiomer is the active.

Sci-Hub | The Resolution of Ethyl 1,1-Diphenyl-3-dimethylaminobutyl Sulfone. Journal of the American Chemical Society, 70(11), 3959–3960 | 10.1021/ja01191a532

But the actual synthesis doesn't make it an 'easy alternative' to make

https://worldwide.espacenet.com/patent/search/family/021839991/publication/US2618640A?q=pn%3DUS2618640

I'm just noting that why someone would choose IC-26 over some far more potent, synthetically much simpler and importantly, much better understood opioids suggests lack of knowledge.

I'm not about to blurt out the names of such compounds but it's worth noting that the US Army researched a LOT of drugs related to methadone in the 1950s and the technical papers aren't aviable (to the best of my knowledge).

But certainly they came up with novel methadone derivatives THOUSANDS of times more potent than the parent. I suppose the UNODC couldn't legally control compounds whose existance they weren't aware of. In this case, they were developed as WEAPONS which explains why they remain on the QT.

I, for one, do not think an opioid some x1500 morphine is likely to result in anything good. Interesting from a technical perspective, but not a good think for general usage.

 

[notsmokeymcpot42088]

I tend to agree 1500x morphine is not for me. Anything than can kill you in under 2 mg I would classify more as a chemical weapon that if you are really a determined outlier can be used for recreation. If the 'far more potent' than IC-26 are in the possible death in under 5mg and a long duration I could see a moral -- even a "Dead body's are bad for business" logistics but when they have cychlorphine on the list idk.

lack of knowledge it could be -- I am not seeing any particular reason they went in that direction. Beyond my paygrade.

 

[4DQSAR]

It IS possible to produce dose units that contain a reliable (±2%) doses but the problem is that street users only ever consider opioids as powders. If presented with a windowpane or similar, the first two questions would be.

'WTF is this?'
'How am I supposed to take this?'

With windowpanes one can swallow or inject - but not smoke. H is commonly smoked by a lot of users.

I GUESS the only way would be for someone to initially sell them cheaply or even give them away so regular punters (read 'dependent users') WILL know what they are and how to use them. But such a thing would quicky be detected by the authorities. I presume that is why fentanyl comes as powder or fake pills. Forms people recognize.

 

[notsmokeymcpot42088]

Those would be my first two questions alright. To be fair at this point I pretty much want to know where the script came from.

Probably for the best only people who are highly determined and well researched have (any) ability to procure such substances. Those fet roxi's sent alot of ppl over the cliff quick, even knowing what they are. Chasing oxy euphoria with fet is a BAD IDEA MMKAY kids. lol.