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sooo, taking oral pregnenolone will keep me from getting stoned?

Engage

Engage

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"Pregnenolone, a molecule produced by the brain, acts as a natural defense mechanism against effects of cannabis/marijuana in animals.[8] Pregnenolone prevents THC/Tetrahydrocannabinol, the main active principle in cannabis, from fully activating its brain receptor, the CB1 receptor, that when overstimulated by THC/Tetrahydrocannabinol causes the intoxicating effects of cannabis/marijuana."

From wikipedia article on pregnenolone.
 
It may damper the effects of marijuana some but I highly doubt it will keep you from feeling it's effects completely. As stated on Wikipedia pregnenolone is naturally occurring in our brains, so unless your taking obnoxious amounts of it it shouldn't do anymore than slightly blunt your high. No pun intended.
 
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