From what I've read on here, I think I process loperamide a bit differently from many others. I find it takes a long time to start working (2 hours or more). I also find that I don't get increasing therapeutic effects when taking more. I don't seem to get much more help from 40+mg than I do from 12mg, except the larger the dose the more lethargy I feel the following day.
That's the other thing - does anyone else get crushing lethargy from lope?
Not just the lethargy that is typical of opiate WDs, but a feeling of reduced lung capacity and being short of breath, heavy, and lightheaded if I stay upright for more than a few minutes. And while it is useful in reducing the daytime restlessness and anxiety from WDs, it does not help me to sleep (despite the lethargy) or lessen RLS.
Sorry - didn't mean to hijack the thread, but perhaps this info may be useful in some way.