Opioids snorting tramadol

[tunesey]

I have some 50mg Tramodol capsules and although good for pain relief you don't get much of a buzz from them. So here is my question can you snort the powder from these green and yellow caps and will they give you a high

 

[Screaming_Skull]

Probly NOT WORTH IT. I had been completely opiate free for a while and my friends dog was hit by a car and prescribed Tramadol. After the dog quit taking them there were PLENTY left over, so I helped myself. I did not snort them, but decided to plug 6 50mg tramadols and for some reason I did not get much from it(made me wanna poo really bad though), if I got anything...They seem to work best orally, which with a low tolerance they put me in a really good mood orally, or are REALLY GOOD at potentiating other opiates.. Just don't exceed over 400mg in a 24 hour period because of the seizure risk..

 

[WayToGoJoe]

so i have been prescribed Tramadol. its a shit semi opiate none opiate(its not a opiate). dont snort it you wont get a better buzz or high from it. u might hurt ur self though

 

[tunesey]

Thanks guy I did take 100mg with 60/500 co-codomol and recived a nice warm buzz. I have a CWE on the go so will try some tomorrow with the codeine extracted from my CWE. Always a bit paranoid about doing CWEs though as you never can tell how much APAP you are getting. PS I wont drink the liquid unless it is clear many thaks take care

 

[Rybee]

decided to plug 6 50mg tramadols and for some reason I did not get much from it

The oral bioavailability of Tramadol is ~75%

The rectal bioavailability of Tramadol is ~77%

Due to this, there's just no point in snorting or plugging them. The sheer mass of powder you'd have to snort will give you a horrific drip and completely clog your nose up. If they had a low oral bioavailability then maybe... But they don't. So just swallow them.

Also as pointed out, don't take more than 400mg in 24 hours due to the risk of seizure.

its a shit semi opiate none opiate(its not a opiate).

To be honest I don't know what a 'shit semi opiate non opiate (its not an opiate)' is... Tramadol is a synthetic opioid with additional SNRI properties.

 

[falsifiedhypothesi]

tramadol itself does almost nothing for your high. o-desmethyltramadol is made by you body when you eat tramadol. it is much more psycho active than tramadol. So basically the only efficient way to take tramadol is to eat it.

 

[Lorne???]

tramadol itself does almost nothing for your high. o-desmethyltramadol is made by you body when you eat tramadol. it is much more psycho active than tramadol. So basically the only efficient way to take tramadol is to eat it.

That is utter bs. I don't know why people think you have to take pro-drugs(such as Tramadol, which is converted to des-tram(aka M1) as the previous poster mentioned, and codeine, which is metabolized to morphine and C6G) in order for them to be effective. Drugs are metabolized the same way regardless of MOA; the difference is that orally it is subject to pre-hepatic extraction. And in the case of tramadol, more gets converted to the major, inactive metabolites, M2 and M3. First pass produces only a minute amount of M1, which is responsible for the opioid effects.

So technically, IV is the most effective route for tramadol, well at least with acute use, with chronic use oral BA increases to such a point that there would be no appreciable difference(note that they're isn't much of one anyway)

But other than that, everyone is right. Oral is the ONLY practical way to take tramadol tablets. As pointed out, nasal BA is no better than oral(I've seen studies indicating it is slightly worse) and tramadol burns like a motherfucker. Rectal takes longer than oral to set in, the BA is the same, it's not worth the trouble. And injecting tramadol would be fucking retarded, so, eat them up... (and be careful with tramadol, as mentioned, it's so weak, yet the side effects are terrible...)

 

[tunesey]

Thanks for the info guys I have been taking tramodol for over a week now but have been taking them along side co-codomol 30/500. I take around 150mg of tramadol with 2 of the co-codomol tabs as I am in alot of pain. Can this amount of pills cause WDs because at 4 am this morning I woke up shivering. I personaly think I am coming down with something but you never know so have cut down to 1 tramadol and one codeine tablet 3 times a day and so far no shivers just feeling shitty so must have a bug or something

 

[falsifiedhypothesi]

So Lorne, you are saying that I'm wrong but right?

 

[Lorne???]

Well of course des-tramadol is the active opioid, it is 100-200x more potent than Tram itself. In fact, a fun fact: M1's binding affinity is actually HIGHER than oxycodone's, according to some sources. For all practical purposes, tram is useless as an opioid with only negligible affinity for mu receptors(and effectively none for kappa and delta, as tramadol and M1 are highly Mu selective)

So your right with the message to swallow them, however wrong about oral being the "only effective" way. As I said, MOA is irrelevant, it will be still be metabolized to the active form.

But definantly take them orally. I only posted to help clear up a misconception that pro-drugs have to be swallowed to be active, or oral Codeine/tramadol is more potent than parenteral, as it is simply not true.(at least not with tramadol, but it is true of some other pro-drugs, but no opioids that I know of).!Their is a lot of misinformation floating around, and I would like to clear it up. That is all.