snorting mescaline

[SKL]

Synthetic mescaline HCl definitely does circulate, but not widely ... It's not at all difficult to synth, really, no harder than the 2C compounds to which it is so closely related, but as the doses required are high, the price per trip is pretty astronomical in comparison, so it's a niche market at best.

Snorting mescaline would probably be remarkably painful and I don't think it would necessarily be worth the discomfort, and snorting such large amounts of compounds can be wasteful too.

As far as I understand it MAOIs can be used with reasonable doses of mescaline without much fear, but it's relatively unexplored territory.

 

[Delsyd]

Actually i remember reading quite a few mescaline (in cactus form) and MAOi reports on erowid.

I cant confirm this now because im at work and erowid is blocked here, but if memory serves correct then yeh, i think erowid has some reports.

 

[tryp2fun]

Mescaline is metabolsed by MAO-b enyzymes; haramala alks mainly inhbit MAO-a.

Also- there is MAO enyzmes in the bran.

Do you have a reference for mescaline being a substrate for MAO-B? Most people assume that it is, but the only published data that I can find did not see activity. In the paper I quoted I believe that they used rabbit liver, not isolated enzymes. They found no MAO activity in liver with mescaline, and liver contains both MAO A and B, I believe.

 

[hamhurricane]

]Harmaline does potentiate mescaline, not because of MAO inhibition, but more likely due to its own central effects.

that makes very little sense, the central effects of harmaline are hardly pronounced enough to account for a three or four fold increase in Mescaline's potency. TiHKAL reports potentiation of the Mescaline not an additive effect as well.

Im not sure why everyone loves the throw the word hypertenisve crisis around every time MAOIs are mentioned, i have safely combined moclobemide and 2C-D on several occasions without any added stimulatory effect, it allows for a full blown trip at 30mg if not lower. im not trying to encourage reckless behavior but i think they are a valuable tool in the psychedelic arsenal.

i need to look more into SSAO, moclobemide inhibits SSAO but im not sure how strongly...

 

[visionbird]

Mescaline can be potentiated with MAOI's but I doubt that it would be 3-4times and MAOI's do add their own flavor... when you combine any two things you get something different no matter what it is. Things like diet and such effect trips ... caffeine, sugar intake etc. Snorting mescaline does indeed work but thats a helluva lot to snort. I wouldn't recommend it other than for novelties sake or to boost an oral dose.

 

[Newmoonrecord]

Mescaline can be potentiated with MAOI's but I doubt that it would be 3-4times and MAOI's do add their own flavor... when you combine any two things you get something different no matter what it is. Things like diet and such effect trips ... caffeine, sugar intake etc. Snorting mescaline does indeed work but thats a helluva lot to snort. I wouldn't recommend it other than for novelties sake or to boost an oral dose.

It is nearly 5x stronger on a full-on MAOI from my own experience. But everyone has different levels of mao enzymes

 

[artic]

Just eat it.

 

[amanitadine]

I've always thought the insanely high dose of mescaline required was an integral part of the experience, colors it, and in a good way. and goddamn, the sulphate salt is beautiful. i've thought about alternate methods of administration but for me that looong comeup is a critical part of the experience. 400 mg of mescaline sulphate is one of my ideal psychedelic adventures, so full, so lovely, mmmmmmm

 

[grue]

As I see it, MAO doesn't need to be a substrate for mescaline, inhibition could magnify e.g. subsequent monoamine activity. Drug effects are gestalt, we know this. For one sympathomimetic activity, which seems (to me) to have some considerable level of variation on an individual basis even for any specific phenethylamine sympathomimetic.

I think we should err on the side of caution, no?

Also, for anyone who doesn't know it definitely appears that reversible MAOIs are less dangerous than e.g. Nardil even at doses of either that look like full inhibition. The reason why? I don't think it's clear, but iirc this is even touted by the makers of moclobemide's brand drug.