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Small Qs and As about chemistry

This is probably more of a thurough answer than Beenhead wants, but I'm just trying to procrastinate from doing Differential Equations.

Mescaline is 2-(3,4,5-trimethoxyphenyl)ethaneamine. This means that it has a primary amine. This amine in many cases acts as a Bronsted/Lowry base and accepts a proton to become the 2-(3,4,5-trimethoxyphenyl)ethanaminium cation. In the case of using HCl as the acid, chloride is the conjugate base and the anion that stabilizes the aminium cation present on the protonated Mescaline. This separation of charges between the aminium cation and chloride anion causes Mescaline HCl to behave more like an ionic compound. Ionic compounds tend to dissolve better in water, which as a large dipole moment. A lot of them also form better crystals, and have significantly different melting points and boiling points, as nuke alluded to. In general, the relationship governing the behavior of a molecule with a certain pKa in a solution with a certain pH is governed by the Henderson-Hasselbach equation:

pH = pKa + log([A-]/[HA])
 
The above paper is littered with the type of expressions listed below.

[F(2,48 )=6.213, p>0.04]
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Fucking ANOVAs; degrees of freedom and all that shit; Just focus on the P>? What that means is that if the P=0.05 the is a 0.05 chance (1 in 20) that the difference is due to chance, Most people think that if the P is less that 0.05 than the two groups must be different, rather that just a fluke.
 
Thanks nuke and hussness, This has been bothering me for a while! Both answers combined were pretty much what I was looking for!
Yes, calculus sucks, but I have to take trigonometry this month, then right smack into calc in the fall... wish me luck!
 
Why when 5-HT/DA/NE systems are so common, is PEA never mentioned?

Is there such a thing as a PEA reuptake inhibitor? (or a PEA transporter)

We already know PEA and DA is a substrate for MAO-B, and this is the enzyme that selegiline disables.

I think amphetamine is a robust non-metabolisable PEA mimic. I dont know a hell of alot about pharmacology but would you agree with this statement?
 
Well, it seems a valid guess. Do Selegiline and PEA have amphetamine-like effects? I know phenylalanine + selegiline do.
 
because there is no salt in it , so it would be similar to throwing a Tarpon into a fresh water pond. You must use a saline solution. Areas with a high solvent concentration tend to be drawn to areas of lower solvent concentration. Like a ciggarette's smoke in a room it dissociates to evenly distribute around the room. Osmosis basically
 
Im having trouble figuring out when its okay to use the Five Percent Rule when calculating Acid-Base Equilibria. I hope this isnt to dumb a question but I really dont have anyone to ask right now and You guys are so good at answering questions :).

Thanks!
 
BilZ0r said:
Okay, I got into an arguement with someone. I don't know a lot about chemistry, but I'm sure I'm right. He has a PhD is plant-extract pharmacology (including the chemistry) so he should be right.

Anyway, he says, long chain primary alcohols are more polar that short ones, i.e. butanol is more polar than methanol.

I say that is rubbish because more carbons can donate more electrons to the oxygen, reducing the polarity, and of course long chain alcohols don't disolve in water (where do they stop? Pentanol?) Thanks.
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Of couse you're correct and for the reasons you give (how the fuck did he get a Ph.D. is his understanding of organic chemistry is so fucked) - don't do yourself down about your chemical knowledge, you obviously know more tham them on this subject (or are thay one of those monsterous egos that cannot ever admit that they might be wrong, even when they reaslizr themselves that they are?).

For a quick rebuttal, if higher alcohols are more polar, how come the solubility of polar compounds (eg salts of amines) decreses so quicky? They require more polar solvents to support greater solubility in general (there are some quirks, but chemistry isdn;t as precise as some would like to think!)
 
Beenhead said:
Im having trouble figuring out when its okay to use the Five Percent Rule when calculating Acid-Base Equilibria. I hope this isnt to dumb a question but I really dont have anyone to ask right now and You guys are so good at answering questions :).

Thanks!
Click to expand...

Man I suck at this too, and my English sucks too, but I'll try to explain it:

It gives you the precisity to "round up" your value to, for example if the 5-percent number is 0,028 and your value is 25,4321 you write the solution as: 25,432 (+- 0,028 )
I hope I'm right about this.. :\
 
Um, pipe some N2 in from a N2 gas bottle into whatever environment (such as a RB flask) you need to have a nitrogen atmosphere for.
 
What's the reason why amphetamine is mostly available in sulphate form? Would it improve anything (e.g. water-solubility?) if amphetamine would be in hydrochloride form? I've gotten used to the fact, that when something is in the hydrochloride form, it's well soluble in water ...
 
It's actually a bear to make the HCl salt of amphetamine. I don't know why, the HCl salt of MeAmp is easy and the HCl salt of most any other primary PEA/AMP is easy as well. The sulfate or phosphate is quite easy though, drop some sulfuric or phosphoric acid on the base in Acetone and it just falls out.
one of the great mysteries of nature
water solubility doesnt effect it's pharmacology. once it hits your stomach its essentially the HCl salt anyway.
And for an instance where HCl salts are not water soluble, take a look @ 2CB
 
No. AMT = alpha-methyl-tryptamine

The amine is primary. You /could/ make N-methyl-alpha-methyl tryptamine however if you wanted to. I just don't think it would be very interesting.
 
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