I've seen more experienced folk here in PD become quite incensed when drugs such as DOI are dissed as being unenjoyably body-loaded. Even Psychedelics that are known to be heavy on the system can still clearly be highly effective & enlightening chemicals. Few would argue for instance that the high liklihood of vomitting on mescaline should put you off trying the drug, & many would say the same for Ayuasca. Indeed it might be that some of the lighter, more easy going Psychedelics could be described a being un-enlightening, or not deep enough by fans of, for instance, LSD.
Doc, in my past experience, produced no more or less physical discomfort than any other psychedelic taken in comparative dosage but certainly produced remarkable, long-lasting psychedelic effects which I thoroughly enjoyed. It's the only Doxx compound I have tried.