The mere taste of burnt mushroom (and apparent potentiation) when I was already on an oral dose of them once sent my trip into a negative, hectic, ugly and gore-y theme. I would personally never do that again. Mind you I am not saying that I believe that smoking mushrooms inherently makes it negative, but the sudden onset combined with the aversive smoke - sooo much more so than with DMT - can be difficult at the very least.
As for smoking LSD and the chance that you will destroy it, added to how pointless the advantage probably is (injecting it as well) because it gets absorbed very well... makes me disintested in the topic. Must be something for people who like to do everything the hard way just because they can (and perhaps they don't know what to do with themselves - ahem I will stop with the judgement now

).
In any case, apparently most of the LSD is destroyed before it hits the brain either way so even if you consider how small an active dose is, only a fraction of that is
truly necessary. Not sure how true that is for other drugs?
And then there is also the theorized saturation effect. Beyond some point it may matter less if you keep adding. There is a long ongoing debate on that.
Wow, is this thread derailed so much that I can't even really tell how much it has derailed anymore?
I don't really have a problem shooting the shit about a number of topics here for the moment, seems interesting enough, but we are working in the margins of the rules.