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Stimulants Serotonin related drug use questions

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blight12

Bluelighter
Joined
Jan 28, 2012
Messages
1,628
Being on high dose SSRI, Paxil, I would like to confirm some combined Serotonin related drug use queries, especially since I am a bit confused about why some Serotonin drugs combined result in one being blocked and others result in synergy or the risk of Serotonin Syndrome.

For example SSRI and MDMA = blocking the effects of MDMA (I have tested this why wolfing down tons of pure mdma and getting only mild amp like effects) but MDMA and DXM can be dangerous and cause extreme Serotonin release, which i confirm with tons of info on this form.

My queries:

1. I would like to take DXM regularly or when necessary in therapeutic doses (30-45mg) for opiate, kratom and amp tolerance related benefits, while being on 50mg paxil daily. I have tried this a few times on separate days and did not feel any issues.

However I would like to confirm if this should be ok theoretically, especially due to the low DXM dose which i would never increase.

I know its a dangerous combo to mix, but in this case is it a calculated and acceptable risk due to the significant benefits i definitely do receive (based on a few tests) regarding my 3 favorite drug types?.

I am certain the DXM dose makes all the difference when it comes to the risk, am i right?

2. I am considering Kanna use since its indigenous, cheap and available. Based on its SSRI activities, I would like to know if its effects would be felt, blocked by my Paxil use or if it would be risky due to SS related activity when combined with the Paxil use.

Lastly, but not necessary, if somebody could clarify how to easily check if a Serotonin related drug combo would cause blockage of one or if it would be dangerous due to increased strength and health risks, that would be great (just for the sake of interest really). What makes the difference?

Thanks!
 
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Your question sounds pretty advanced to me. I'm guessing if your above statement about SSRIs and DXM in relation to MDMA is factual then its mediated not by re-uptake but by release, as you kind of stated.

It really depends how much MDMA you are using, and when. Also keep in mind that you may not be getting purified MDMA, or another chemical could be present too. Anecdotally I find SSRIs to augment each other. I don't think it would be risky because titrating a kanna dose is fairly simple if you're smoking it. What method of ingestion do you plan to use? Now if you're using kanna, MDMA, and paxil all at once I would probably be concerned, even if it doesn't pose an imminent threat in terms of serotonin syndrome. Combining three drugs which all raise the levels of one neuro-transmitter is a general rule of no-no, don't ya think?

The best rule of all is to start too small. You can always take more but its a hell of a lot harder to negate something that's already made its way into your brain.
 
Thanks, good info! Just to clarify there will be no MDMA use here, not used in 7 years since it broke me.

But it is the cause of the SSRI use daily. So the query is more the combo of SSRI + either low dose DXM OR Kanna use and the results.

The Kanna question also is because I am unsure if all the info about it is as an SSRI is that it actually technically/medically acts as one OR if it causes the same beneficial effects of one, but physically functions in a different way. That clarification should answer my question as well.
 
Well I've taken 20mg paxil and 100mg dextromethorphan and while paxil binds very strongly dex does more. I have heard it is an SSRI too. A rudimentary search yields that its also a pde4 inhibitor and may have dopaminergic as well as chollinergic effects, but is an SSRI. You should be fine if you titrate the dose up slowly. I found that you can take it through pretty much any route (save IV, obviously). I would ingest small small amounts and go from there.
 
Thanks bud that does help and makes me feel much better. As i say, i dont experience any issue when i tested this a few separate times, but I worry if there might be damage even though i dont feel any issues, especially for longer term use for tolerance control.
 
Not unless you're taking an opiate that has serotonergic activity like demerol or if you're taking amp in doses of 100+ or methamp. As to damage I doubt it in such a low dose, just don't use a shit-ton of kanna (use common sense here) and the brain should be able to recover on its own. But you do run into possible (read: possible neurotoxicity of long-term amphetamine use and addiction with opiates as well as unknown risks of using kratom and kanna since they aren't officially recognized as medicines and therefore adequate tests have not been done on them).

If you ever decide to come off of one of these medicines be extremely careful, giving yourself a lot of space and time.
 
Thanks. I do use methamp in higher doses across weekends only and dont have any issues used along with my Paxil dose. For this combo Ii understood the lower effect methamp has on Serotonin is simply blocked by the SSRI
 
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