I think the key is being able to function with as little need of outside help as possible. It’s very easy to justify using something that makes everything better, it is harder to determine if we have a real need for it.
I’m currently dabbling with M as a therapeutic tool to help me mentally process, in a safe place, the current reality we live in. Previously I had only used it to amplify sexual pleasure, so this is a novel way to use for me.
I found this article which mentions specifics of therapeutic dosing.
“To avoid toxicity, current FDA guidelines consider acceptable dosing (for both adults and children) at 25 mg within a 24-hour period.”
The article primarily looks at M as a protective agent in patients post stroke. For those patients, they determined the therapeutic dose to be 17.9mg (total for 24hours) for a 70kg (150lb) person. I believe it is safe to assume that anything above these above mentioned levels would begin to cause neurotoxicity.
I acquired a scale that weighs in mg and veg capsules in order to weigh out an oral dose. The study puts oral bioavailability at 70%.
1.) https://doi.org/10.1016/j.pnpbp.2015.02.013