Selegiline---- Panacea ?

[VelocideX]

I agree that some of the stuff is complete rubbish, but there's a reasonable amount of evidence that piracetam (for instance) improves memory under circumstances where it would be diminished i.e. "memory stressors", for lack of a better word. Scopolamine impairment is the classic test, but it's been shown to protect against ischaemic damage, for instance

 

[Smyth]

http://www.biopsychiatry.com/index.html

One thing I forgot to mention is that MAO-B also metabolises PEA as well as dopamine.

There is some evidence that chocolate (rich in PEA) does have some life-extending properties. But unless you are a pensioner, u dont really have to worry about that.

 

[yaesutom]

Oh, maybe nanobrain would know about this....

Well i've taken piracetam before daily, and definitely, notice my multitasking ability improved (among other things) - shit, its what i noticed the most. Once I was on the phone with someone, they were telling me a phone number to write down, and i had a friend in the same room with me, talking to me, and I was writing the number down as she said it, and listening to him FULLY, and at the same time, part of me was able to look at the whole thing and go "wow, this takes no effort!" - usually someone telling me what to write down my mind is more "linear" and kinda switches back and forth between hearing, and writing (sorta). This was like total parallel processing, and effortless.

Anyway, nanobrain - DMT and piracetam... holy fucking shit, um, "BAD"!! I couldn't narrow it down to anything else.. There were two times, once I took DMT orally w/harmaline during a piracetam daily thing, and oh god, when the DMT hit, it scared the SHIT out of me. No visuals, i heard my own voice come out of the radio speakers saying "wow" and other things, now, its normal to hear voices and stuff on DMT, but "something was not right". I felt like schizophrenic or something, i don't know how to explain it other than things in my head were getting routed to the 'wrong' area's. Panic. The solution? GBL! (actually it was 1,4-butanediol). I tried to stay calm and take my 1,4 bottle eye dropper thing and i managed to drip enough drops into a gelcap (how i would always take GBL/1,4, tasteless), for one capsule, as i was doing this my hands would start shaking almost violently like "something bad" was taking over, taking control, but not in a good way. I managed to quickly swallow this one capsule and knew i wouldn't be able to do a second. So I tried to sit calmly and wait. It worked enough eventually to cut the shit out..

That was the first time anything like it ever ever EVER happened on DMT, and I did not know why, i actually thought it was a 'bad DMT trip' or well i just had no explanation for it.

The next time it happened, was taking piracetam daily like before, smoked some DMT, not much, but as i inhaled the smoke... some "red alert" flag was set and i KNEW the feeling so i blew out the smoke as fast as i could, same shit, scary, "just NOT RIGHT", and stayed in one position until the effects of the DMT wore off (both of these times did not feel like DMT would normally).

This didn't happen all the time, on piracetam, but i dropped the piracetam totally, and well, DMT has been like DMT should be ever since.

I was not taking choline supplements with piracetam, maybe that was the issue..

But, as i'm a DMT addict/freak, um, of course, i quit piracetam for good then. All better . But christ piracetam FUCKS with DMT! Other psychedelics might be enhanced or whatever, but as DMT works differently (sorry, no scientific proof i can give anyone, hehe.. only DMT freaks would understand, i guess lol) whoa...

DMT is now DMT all the time everytime (which is always = great). I'm curious if it was from taking piracetam without choline supplements... but really who knows.. All i know is other DMT freaks have said, piracetam really fucks with the DMT experience although never read about anyone experiencing what I did those couple times. Only GBL/1,4-b / ghb would put an immediate stop to it (forget benzo's etc).

 

[nanobrain]

^come to think of it, there were a couple times when smoked DMT with a background of piracetam produced undesirable effects – mostly physical and auditory, not much in the visionary / visual way, somewhat paranoia-inducing and disabling.

at the time, this was thought to be due to the DMT quality (then source proven less than entirely trustworthy later) and the cumulative effects of the copious polypsychedelic spree at the tail of which (multi-day bush doof) said DMT was smoked at sub-breakthrough.

but in retrospect, i rethink – and this is what i’ve thunked, so bear with my SWAG:

while the effects of the racetams may be perceived by some as subtle, the mechanisms of their action are undeniably rather multifaceted.

enhanced cortical GABAergic inhibition, enhanced interhemispheric (transcallosal) transfer, potentiation of already present neurotransmission, increased 5-HT and DA levels and turnover in the cortex – what you’ve got is a whole host of actions leading to modulating effects on the action of the radical psychedelic DMT when thrown into the human system.

the analogy fuelled by fucking w/the mixer cables while soundchecking for my last gig - in a sense, racetams act as a preamp, throw in the DMT and you’ve got too much signal unless your ‘gain’ and ‘level’ are turned down way low, and especially with the racetams effects on the corpus callosum, you could be creating a feedback loop, overloading the circuitry, and creating mucho distortion.

as the manual says: please remember that you can only use either the microphone or the line input of a channel at any one time, you can never use both simultaneously!

now, given good shielding and solid components (not the case at my last gig), nothing should be blown/permafried, although you may have to reboot, but doesn’t distortion suck?

anyhow, the conclusion: further research is required…

 

[MolokoVelocet]

nanobrain I am in awe of your infinite nano'iness. if you were a girl i would hunt you down and force you to bear my children. That means 9 months in my basement. I would feed you drugs ofcourse

 

[zorb]

Do any of you guys have experience with benzodiazepines and selegiline?
i.e. knowledge of contraindications?

I can find no mention of this in my research, but am still wary..

 

[nanobrain]

^not contraindicated

 

[yaesutom]

LOL.. nanobrain..

Yeah, definitely disabling to say the least. Downright scary.. Now that I think about it, I posted a trip report a long time ago for a scary capsulehuasca experience where I thought maybe I was being freaked by some spirits telling me to not "abuse DMT". I was taking piracetam daily.. I did notice it was related to what time I took the daily piracetam dose also, worst when the piracetam was peaking.

DMT, being a neurotransmitter regulating important functions in the brain (just my subjective thoughts), once I figured out it was from taking piracetam I stopped taking it.. I guess normal brain DMT levels might be OK but something about it just didnt *feel right*. Dropped the piracetam and the scary DMT experiences dropped 100%.

I remember as the spice smoke would be inhaled, it felt like piracetam was creating some "barrier" and getting close to this barrier, or too close, would result in some crazy fucked up brain signals just going to the wrong places. I could immediately tell, before any audio/visual crazy shit, and would blow out the smoke fast. Then i'd sit still feeling wrong and wait for it to go away.

After about 2.5 weeks of selgiline (and NOT drinking -- this is important), something truly hectic happens to my memory. My memory slowly improve for 2.5 weeks or so, but overnight my memory becomes essentially eidetic/photographic.

Now when I say this, I mean I can memorise enormous quantities of information with essentially zero trouble.

For example: I memorised 212 pages of statistical physics notes in two days, and got 97% on the exam. I memorised 180 pages of notes on theoretical quantum mechanics in two and a bit days and got 98% on the exam.

The effect ceases within a few days of stopping the selegiline, and is (interestingly) destroyed by drinking. I went out and had half a bottle of wine one night, and the effect vanished for 3 days, then returned.

I have a good memory normally, and am intelligent, but this sort of feat is not within my grasp.

Perhaps even more interestingly I have the memory without the perception of having learned the material. I don't have the feeling that I know any of it, but when I go to write it down it's all there, with 100% accuracy.

This is interesting.. I was talking with a friend one day, he was doing some take home final exam for a class and we started talking about studying and memory. He said he doesn't ever remember having to study or doesn't even remember learning things, pretty much described what you are saying, he can just pick up a book and read tons of pages and thats that - no 'studying' required. Knew another friend with a photographic memory, when he takes a test, in his mind he doesn't remember the words or concepts but usually just remembers a vivid image of the entire page and reads the info. off the page in his mind.

Interesting to know that taking a drug can help cause this, so its not necessarily "you gotta be born like that".