• BASIC DRUG
    DISCUSSION
    Welcome to Bluelight!
    Posting Rules Bluelight Rules
    Benzo Chart Opioids Chart
    Drug Terms Need Help??
    Drugs 101 Brain & Addiction
    Tired of your habit? Struggling to cope?
    Want to regain control or get sober?
    Visit our Recovery Support Forums
  • BDD Moderators: Keif’ Richards

Selegiline + oxycodone

K

Kudos

Bluelighter
Joined
May 3, 2007
Messages
172
Is this combo dangerous only due to serotonin syndrome? Is this going to happen at virtually any dose, say even 1mg of oxycodone? Or does the selegiline just act as a massive potentiator?
 
I'm 99% sure opiates (besides tramadol demerol and a few rare others, but not oxy) don't have any effect on serotonin levels. And doesn't selegiline only affect dopamine too? MAO-A inhibitors affect serotonin but Selegiline is an MAO-B inhibitor.
 
Selegiline itself does not directly effect serotonin, but its unique MAO-A selectivty makes users at a much higher risk in serotonin toxicity. Its not recommended to combine any serotogenic drug with selegiline. Oxycodone hasn't been shown to have very much serotogenic activity but there have been reports of serotonin syndrome when combining oxycodone and an ssri.

I believe the chances of serotonin syndrome with oxycodone and an ssri, or a drug like selegiline is very rare. Just be aware it has happened.
 
You must log in or register to reply here.
Top