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  • BDD Moderators: Keif’ Richards

Selegiline, amphetamine combination

Issac Sinclair

Issac Sinclair

Bluelighter
Joined
Jan 27, 2011
Messages
381
Taking both Selegiline and Adderall/Dexedrine.
First day I thought I wasn't going to get it. I took 15mg Dexedrine before, then took 2.5mg after it came. It didn't do much at all besides lengthen the duration, took Atarax to sleep, so not much stronger. I take it after eating, and it seems to be very weak.

I thought I would have some sort of stronger reaction to it, but even though its an MAOI inhibitor I guess I'm not very affected by it, or its bunk. I'm dosing the same amount of amphetamines that I take normally, with no noticeable difference besides duration. I think I might look better, but I normally think that just on speed.

Any reason for this? Does it take a while to work like antidepressants, or does it just not work for me? I thought it would be a night and day difference as I read up on it and heard about dangerous interactions. Then I read more and it seems that cheese syndrome or serotonin syndrome itself is very uncommon. I didn't have any sort of overstimulation either.

What should I 'tweak' in my habit? Decrease/increase amphetamine/selegiline? What should I do with my diet? I would prefer not to snort it, but if it works better I will. I think its somewhat working since when I ate cheese I had a slight headache, but man, I thought this stuff would be much more powerful, an MAOI and an amphetamine? But they do almost nothing!
 
Well there seems to be no effect besides them last longer. I thought it would be like 300-500% stronger. Nope, its like at best 101% stronger and 170% longer in duration. Any more help?
 
I ended up having a seizure when I took them twice at the same time. I suggest against that. I'm going to lay down low on the drugs for a bit.
 
I am very sorry to hear about your seizure. I'm sorry that nobody was able to help you before it occurred.

It seems to me your l-deprenyl dose was too high. I would stick to 10-400 mcg with droplets under the tongue. However, there is always inherent danger in combining drugs that work on similar or in this case identical pathways.

Seleg seems the most promising in low-doses. There is a popular mistaken belief that the MAO-B properties are what is beneficial. This is likely only a very small reason for its effects.
Otherwise, other selective MAO-B inhibitors would generate the same benefits; e.g. EVEN the enantiomer d-deprenyl does not exhibit the same benefits.

At a dose of 5 mg, 0% of MAO-A and like 90% of MAO-B are inhibited, I believe. The cheese effect you experienced was probably placebo. At mcg doses, the MAO-B inhibition is weaker but like I said that's not what you are after anyway.

I believe that l-deprenyl is amazing and I hope you are not turned off by your experience. Please just exercise a bit more caution next time.
 
Yeah I wasn't being too smart. I was taking about 5-10mg a day. I had amphetamine, 2CE and also Namenda. The Namenda was what fucked me up the most. I was having a DXM comedown the whole time on that, my eyes were dilated, and I couldn't think at all.

I'm not sure if I had a seizure, I just kept falling asleep and waking up in a pile of drool. I assume that I had maybe 1-4 seizures, but I really don't know.
 
Thank you very much for caring.

It truthfully wasn't amphetamine that did it, unless it was a high amount (perhaps). I think the danger lies in 2CE combination.
 
Issac Sinclair:
I'm going to try and unravel your drug cocktail here.

  • 2C releases DA and is metabolized by MAO-B.
  • You combined this with amphetamine (very similar to 2C)
  • Amphetamine inhibits DA metabolism
  • L-deprenyl inhibits DA metabolism
  • Insane overload of DA!
  • DXM is an NMDA receptor antagonist
  • Memantine is an NMDA receptor antagonist
  • Memantine is a DA agonist!
  • More DA?

I can't even wrap my head around what exactly happened here but it seems that the amphetamine/l-deprenyl was the least of your concerns.
 
NeighborhoodThreat said:
Issac, I'm glad to hear you're okay, please, don't combine MAOIs and amphetamines.

Please don't do it.
Click to expand...

L-deprenyl is not your standard MAOI. Firstly, it is selective MAO-B; secondly, at low non-chronic doses its inhibition may not even be clinically relevant.
There is some literature and much sound speculation to suggest that the combination of low dose l-deprenyl with amphetamines is neuroprotective (desirable).

an oldy but a goody
http://www.ncbi.nlm.nih.gov/pubmed/7538579
a newer one, with vaguer positives
http://www.ncbi.nlm.nih.gov/pubmed/16490285/
 
Last edited:
Yeah I am never doing that again. I am afraid of Namenda, it felt like a DXM comedown the whole time. I don't seem to have permanent damage, but who knows? Only time can tell. I could feel the 2CE working really well, but then I fell asleep. I have no idea why, besides perhaps a seizure. I was asleep for a long time though, I'm wondering what could have caused that. Maybe my body shut down DA at one point to protect itself during homeostasis. I'm very thankful for your breakdown on the interactions. Sorry I mistated the DXM, I felt like it was a DXM comedown, not that I actually had any. I shied away from that.

Heres what basically happened.
Took 2CE, already took 5mg Selegiline earlier in the day.
Decided to have Dexedrine, about 15mg.
Hey, I have Namenda, I think thats good for me, take that too.
Took another dosage of 2CE.
WOW I'm flying! I can't take this, I'm going to sleep a bit.
Napped, I'll take some Dexedrine so I won't fall asleep again.
Fell asleep again, woke up tripping very crazily. No psychedelic thoughts besides "this is like rebirth."

Throughout the whole day, I couldn't sleep, and tried to clean my room, couldn't do it. I think that was the NDMA working, it felt like shit, and I felt like a zombie the whole day at school.
 
Upon further reflection, you probably did not overdose or have a seizure or anything serious.

You should be fine. Get checked out if symptoms persist. As you'll learn in medical school the vast majority of conditions clear up on their own.

Issac Sinclair said:
I could feel the 2CE working really well, but then I fell asleep. I have no idea why, besides perhaps a seizure.
Click to expand...

I've actually heard many stories of people falling asleep on amphetamines. So perhaps this is just one of those stories. Plus, you mentioned you took a sleep aid at one point (which would account for the drooling, unless it was foaming?).

And the dysphoria the next day... well, probably just the come down.
 
Dexedrine is extremely soothing on its own, and I noticed that the consistency of my saliva was somewhat foamier, but its quite possible that I did not have a seizure. I think I'm fine, but I'm just confused. I had no revelations and I feel like it was a waste, but on the other hand, it was better than nothing.
 
Okay so for future reference, Selegiline apparently loves Propranolol. It makes it super strong, and gives me the same thoughts everytime I take it. I fell asleep because my blood pressure was too low, it wasn't because of a seizure.
 
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