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Sarpogrelate

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surge

Bluelighter
Joined
Apr 26, 2021
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Sarpogrelate is a very interesting compound. It antagonize 5-ht2a and most importantly 5-ht2b only peripherally, because it doesn't cross the BBB. So basically MDMA, APBs, mephedrone, lsd and other DANGEROUS 5ht2a\b active compounds can do their magic unharmful effects on the brain, and do not provoke valvular heart diseases because of their peripheral effects. With this molecule you can COMPLETELY prevent all of this and it comes with little to no side effects. Here is a study that uses it to prevent cardiotoxicity of Fenfluramine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680644/
But it seems that even if it is approved for some stuff, it isn't sold anywhere.
 
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if its illegal darlin, perhaps dont ask in BL. but i dont know surge, you sure seem bright tho, nice to meetcha 👮‍♀️ happy hunting:need drugs:
 
surge said:
Sarpogrelate is a very interesting compound. It antagonize 5-ht2a and most importantly 5-ht2b only peripherally, because it doesn't cross the BBB. So basically MDMA, APBs, mephedrone, lsd and other DANGEROUS 5ht2a\b active compounds can do their magic unharmful effects on the brain, and do not provoke valvular heart diseases because of their peripheral effects. 5-APB and 5-MAPB are the most dangerous substances btw. With this molecule you can COMPLETELY prevent all of this and it comes with little to no side effects. Here is a study that uses it to prevent cardiotoxicity of Fenfluramine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680644/
But it seems that even if it is approved for some stuff, it isn't sold anywhere. Do you know where can I buy it?
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But as a 5-HT2A antagonist it would also blunt the effect of these drugs. 5-HT2A activation is critical in producing the full effect of this drugs. By blocking 5-HT2A you will reduce release of dopamine. 5-HT2A knockout mice (ie mice without those receptors) respond quite differently to these drugs.

Additionally, with respect to 5-HT2B agonists, the clinical manifestation of cardiotoxicity is seen more commonly when they are dosed frequently (like with drugs you take daily, such as dexfenfluramine, etc).

If you have heart issues you should avoid drugs like MDMA, but if taken occasionally in safe doses, the 5-HT2B agonism isn't much of an issue.
 
negrogesic said:
But as a 5-HT2A antagonist it would also blunt the effect of these drugs. 5-HT2A activation is critical in producing the full effect of this drugs. By blocking 5-HT2A you will reduce release of dopamine. 5-HT2A knockout mice (ie mice without those receptors) respond quite differently to these drugs.

Additionally, with respect to 5-HT2B agonists, the clinical manifestation of cardiotoxicity is seen more commonly when they are dosed frequently (like with drugs you take daily, such as dexfenfluramine, etc).

If you have heart issues you should avoid drugs like MDMA, but if taken occasionally in safe doses, the 5-HT2B agonism isn't much of an issue.
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That's the good thing about sarpogrelate, it doesn't cross the BBB, so it can't reach the brain. 5ht2a and 5ht2b receptors on the brain aren't blocked and MDMA can agonize them without any problem, receptors outside the brain are all blocked and that's okay because they do nothing for the psychic effects, they are useful only for side effects like VHD.
5ht2b agonism become a problem if you take APBs because they have a very high affinity for it, even if you take them once a month you will have VHD for sure after a year or so (since it is drug induced it will recover by itself, but better prevent than cure lol). MDMA is only a partial agonist, but in fact it is funny only a fraction of APBs (5ht2b is a positive autoreceptor, so more it is agonized, more serotonin is released).
 
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I remember in 2014 when I fell in love with 5-MAPB I began hunting for substance exactly like this. Now we know the methylated APBs don’t hit 5-ht2b to nearly the same degree as as the non-methylated versions, but this would still be good for 5-APB and 6-APB.

Excited to hear someone give it a try.

-GC
 
G_Chem said:
I remember in 2014 when I fell in love with 5-MAPB I began hunting for substance exactly like this. Now we know the methylated APBs don’t hit 5-ht2b to nearly the same degree as as the non-methylated versions, but this would still be good for 5-APB and 6-APB.

Excited to hear someone give it a try.

-GC
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All APBs are just in another world compared to MDMA. When I take MDMA I am simply in high spirits and with a modest desire to talk to people and hug, nothing more. When, on the other hand, I take 5-MAPB, I enter a cartoon-like world where everything is colorful, bright, I get a sort of curiosity like the one that children have towards everything and I need to get out of enclosed spaces. The only thing I can do is laugh out loud, being in company becomes an obligation. I can just think how beautiful life is and how any aspect of the world is fantastic and waiting to be discovered. I tried APBs before MDMA and when I tried MDMA I was SOOOOO disappointed, so much so that I bought 2 grams and most of them are still gathering dust. At this point I ask if you all get the same effects too or if it is just me who cannot have fun with MDMA.

However, even if 5-MAPB itself is not very cardiotoxic, then it metabolizes into 5-APB, which is very cardiotoxic. The more it activates the 5ht2b receptor the more serotonin it releases as well as having greater cardiotoxicity, so if 5-MAPB wasn't cardiotoxic then it wouldn't be all that much of a molecule.
 
surge said:
All APBs are just in another world compared to MDMA. When I take MDMA I am simply in high spirits and with a modest desire to talk to people and hug, nothing more. When, on the other hand, I take 5-MAPB, I enter a cartoon-like world where everything is colorful, bright, I get a sort of curiosity like the one that children have towards everything and I need to get out of enclosed spaces. The only thing I can do is laugh out loud, being in company becomes an obligation. I can just think how beautiful life is and how any aspect of the world is fantastic and waiting to be discovered. I tried APBs before MDMA and when I tried MDMA I was SOOOOO disappointed, so much so that I bought 2 grams and most of them are still gathering dust. At this point I ask if you all get the same effects too or if it is just me who cannot have fun with MDMA.

However, even if 5-MAPB itself is not very cardiotoxic, then it metabolizes into 5-APB, which is very cardiotoxic. The more it activates the 5ht2b receptor the more serotonin it releases as well as having greater cardiotoxicity, so if 5-MAPB wasn't cardiotoxic then it wouldn't be all that much of a molecule.
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What you describe here is how I would describe the difference between the MDMA I bought from 2000-2005 and the MDMA I have bought since 2005. I don't want to derail your thread, but those semi-boring, moderate effects are what people are complaining about when they refer to the joking phrase "meh-DMA." Although, on most modern MDMA, I can't even say I want to hug anyone. It is just dull. Whether that is my loss of magic or an issue due to changes in manufacturing is up for debate. But, good MDMA can do everything you describe here as being unique to 5-MAPB.
 
indigoaura said:
What you describe here is how I would describe the difference between the MDMA I bought from 2000-2005 and the MDMA I have bought since 2005. I don't want to derail your thread, but those semi-boring, moderate effects are what people are complaining about when they refer to the joking phrase "meh-DMA." Although, on most modern MDMA, I can't even say I want to hug anyone. It is just dull. Whether that is my loss of magic or an issue due to changes in manufacturing is up for debate. But, good MDMA can do everything you describe here as being unique to 5-MAPB.
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Well considering that with APBs the power is there and that I had a disappointing experience even in the first assumptions of mdma. We can say that there is something more than a fucked up brain! In most cases at least.
 
surge said:
Well considering that with APBs the power is there and that I had a disappointing experience even in the first assumptions of mdma. We can say that there is something more than a fucked up brain! In most cases at least.
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I agree with you. I have personally seen other first time users with similar lackluster, "so what" effects. Let me assure you that the early rave and EDM scene would not have been fueled by this lackluster fizzle. Some feelings I recall from MDMA were feeling one with the divine, believing in the possibility of eternity, taking in every sensory detail from texture to smell to taste (most especially touch). There was openness to all ideas and people. Yes, I felt like a child with that innate curiosity and sense of discovery. I used to be the one who brought 80s toys to the party: little velvet Care Bears, slinkys, and play-doh. We were all re-born with our blindness healed and our sight restored. It was transcendent.
 
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