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Ethnobotanicals SAN PEDRO

mr peabody

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Frostbite Falls, MN
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San Pedro, cactus of peace and vision

There is something special about making time in one's life for self-discovery, healing and transformation. We were drinking the consciousness altering liquid made from the San Pedro cactus, Huachuma, native to the Andes Mountains of South America, a powerful healing sacrament used in rituals and ceremonies for thousands of years. I recently returned from spending time away, working with this magical plant on sacred Aboriginal lands.

In the first two ceremonies, the cactus guided me through deep states of presence, meditation, and contemplation. They were incredibly peaceful, beautiful journeys. I could focus on and separate the various vibrations of sound, like the chime of a bell, into their own separate layers of auditory dimension, as they rippled through the airwaves. I felt a deep level of connection to nature through being amongst the trees, grass, birds, sky, clouds and mountains, not just observing myself in nature, but feeling that my energy was one with everything around me, and that nature could sense me as a separate being - part of an inter-connected web of related energy.

There were prolonged states of deeply calm and peaceful meditation, focusing solely on the inhalation and exhalation of breath. With my eyes closed, I saw green and yellow neon-like colors grow and bubble up. Hexagonal honeycomb patterns shifted and rearranged behind my closed eyelids while lattice tunnel-like spirals emanated in and out of vision.

I sensed the presence of other beings. I could see and feel these beings as aboriginal elders and their community watching over us. My experience was far beyond my capacity to articulate, and these altered sensory elements gave rise to fascinating philosophical and contemplative thoughts about consciousness and the nature of reality.

But the real gifts are how these sacred medicines seem to have the power of opening us up to want to live better lives. During my experience I pondered deeply about the meaning, purpose, fulfillment, and integrity, of my message to the world. I reflected on how these sacred healing plant teachers and shamanic medicines have helped me reclaim my life, allowing me to do some seriously transformative, sometimes confronting, incredibly challenging deep inner work.

In my last journey, San Pedro opened doors for me to a much deeper experience and understanding of what this medicine is capable of. It felt like living a lifetime in a single day. It was as though a force beyond myself called me over to drink another cup of medicine; as if the cactus itself knew that I was to be guided into a much deeper journey. This lasted for many hours, and I sensed I was receiving deep cleansing and healing at a cellular level, and that this deep healing extended beyond my own sense of self, and on some level, permeated those near me. A new path of healing opened up, or rather, I realized the depth of healing that still needs to take place.

Somewhere along way, I found I could look into my eyes and see the entirety of my past and future at once - myself as a little boy, my path up to my current self in the present moment, and myself in the distant future as a wise elder.

I received valuable insights on my journey, and while there will always be healing and recalibration to be done, I was shown that I am at a stage of life where it is necessary for me to be of higher service to others, to deepen my relationship with San Pedro, and to learn which avenues of higher service may in time be revealed to me, a message I received quite clearly.

I found integrating my experiences quite challenging, and feel that I would have progressed a lot quicker and smoother if I'd had the frameworks, knowledge, understanding and wisdom that I have now. This is why I feel called to help guide others through their own transitions, transformations and self-actualization.​

I am incredibly humbled by San Pedro, cactus of peace and vision.

https://www.medicinepath.net/blog/sacred-healing-medicine-sacred-aboriginal-lands
 
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Huachuma – Visionary cactus of the Peruvian Andes

By Sergey Baranov

Huachuma is the original name given to the various mescaline-containing columnar cacti native to the Andes known as San Pedro, and used traditionally in Peru for millennia for healing and divination.

The cactus thrives at around 10,000 feet above the sea level and flowers between October and March with beautiful flowers gifting the lucky observer with a gentle scent. Its flower opens for just one day and closing over the next two days. After this the flower gradually dries out and forms a cocoon with new life-seeking seeds. Then it is the turn of the grown cocoon to dry out while releasing the seeds to the will of the wind. Thus the new life is begun.

The most commonly used botanical names are Echinopsis Pachanoi (spineless) and Echinopsis Peruviana (spineful) but these names, of course, are only a shadow of the real essence of the plant, which is spiritual, not verbal. To realize this, it takes more than knowing the plant’s name. An experience is like a cloud which floats beyond the horizon of botanical study.

My introduction to this ancient mystery which begun in 2005, was nothing less than a life-changing event; a fact that has slowly revealed itself over time. Back then, I was a spiritual seeker, who intuitively knew that plant-medicine shamanism held the key to a kind of knowledge that could not be found in books. This type of knowledge was experiential, not intellectual. I was not satisfied with reading about the experience; I wanted the experience. Led by a burning desire and a spiritual thirst that up until then had resulted mainly in disappointment, I was fortunate to find people in Peru who had practiced shamanism for many decades, and were dedicated healers.

This new acquaintance and introduction to an ancient path became a new starting point in my life. My urge was calmed. My thirst was satisfied and spiritual hunger fed. A path of self-discovery ahead was now opened to me with a friendly and welcoming gesture. I kept coming back to work with the same people for three and a half years before I made the decision to move to Peru, which I did in April 2009, after feeling the call to serve the sacred medicine. This of course did not come without a price. I had to make a large payment for the pass. It wasn’t in terms of the money but in terms of the fear of death which was my unwelcome friend from an early childhood. My near-death experience in Mexico while working with Huichol Indians and the sacred Peyote is described in detail in my book. Shortly after that, I moved to Peru. Landing in the Sacred Valley in the Andes, felt like coming home. I knew I wanted to build my new life here around this sacred medicine.


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Shamanism was something I have been drawn to since my early childhood. But living under the Soviet regime, this prospect did not look hopeful. Already as a kid I felt sharply the pain of separation from the sense of life being a miracle. And ‘growing up’ seemed to threaten this further. I didn’t want to grow up believing that life is a process of collecting stuff and saving for retirement. This prospect seemed rather too bleak.

Fearing death as a child, and seeking self-fulfillment from an early age were significant factors in the formation of my spiritual quest. This quest led me eventually to shamanism in Peru, where sacred medicinal plants were not only legal, but embedded in the culture, reaching back as far as the dawn of history.

“San Pedro” is the post-colonial name given to the psychoactive Andean cactus known under different names. ‘Huachuma’ is the old Qechua name, which means: ‘vision’ or ’that which makes one drunk’. It is a visionary cactus with an amazing potential for healing. Seeing the world through its “eyes”, is like being born again, but this time consciously.

With the invasion of the Spaniards in the early 16th century, native shamanic traditions of Peru faced the very real threat of extinction. The brutal intolerance of the Catholic Church would only allow for obedience and conversion, and certainly not ‘paganism,’ or ‘devil-worshipping’ practices, as they generally viewed them. How exactly some of these ancient traditions survived, nobody knows, but I have been entertaining the following thought as for potential possibility. There could have been a deal made. And this was simple – the natives could continue their use of their sacraments whilst worshiping Christian Saints. San Peter was an apostle who, according to the Christian theology, received the keys to Heaven from Jesus Christ. A visual representation of this biblical scenery can be found in the painting by Marco Zoppo from an early epoch of Renaissance (1460) which depicts the saint holding the Keys of Heaven.

Seeing the parallels between the heavenly experience of the San Pedro cactus and the apostolic story from the newly adopted faith, would naturally lead them to the choice of this name. Perhaps this allowance from the Church was made out of mercy or, as a favor seeking gesture in the eyes of God and the indigenous population.

In a similar way, the Qechua people during the Inca dynasty hid their mummies inside the wooden statues of Christian saints during the Corpus Christi feast – an annual liturgical solemnity and celebration of the body of Christ. Thus, while on the surface they worshiped the Christian saints, they were in fact, revering their own.

Another parallel can be drawn between the painting by Marco Zoppo entitled Saint Peter and an ancient carving which is found in the temple of Chavin de Huantar in Peru, an image of a deity, half man half jaguar, who holds the sacred cactus in his hand as the key to the state of consciousness it represents. Being three millennia apart, same symbolism is quite apparent.

In any case, and regardless of theories, the tradition has survived until today, albeit of course, in a form of syncretic religion. And although the cloak of Christian terminology was pulled over its lungs, it hasn’t been suffocated, and remains breathing as the mountains around you when you see them under the influence of this sacred medicine.

Coming to this with my own spiritual baggage, which mainly comprised of reading eastern philosophies and contemplating upon them using psychedelics, was a good thing. I had a context and a ‘’fertile ground’’ in which the seeds of new teaching from the mescaline-containing cactus could spread its roots.

But even though my love for wisdom and a search for answers for life-long questions were my early allies, I have not suspected how deep the ‘jaguar hole,’ actually goes. I can still remember the excitement I felt when I realized that plant-based shamanism was ‘the real deal’ – an authentic path that actually works and is open to those who are willing to step beyond the fear of the unknown while being unsatisfied with the verbal description of the higher states of consciousness as it has been described by others.

The world that I’ve seen through the light of the sacred cactus was beyond belief. Its self-evident truth did not require one. Thus the shamanic perspective which is described as animism in the academic studies has simply become my new outlook. In essence, this is what shamanism actually means. Although it is a very broad name given to diverse practices of healing, in fact, it is a way of living and interacting with the world. Not all of them include the use of psychoactive plants. In Siberia for example, the invocation of ancestral spirits for the purpose of healing is achieved without using plants. For myself, however, this aspect of shamanism was not of such great interest. I was after an altered state of consciousness in which as I hoped, I could perceive the world in a different way, learning and spiritually growing from it directly and experientially. It is hard to describe the feeling when after a long search a person finds a path that is actually fulfilling. And this is what the sacred cactus means to me; an oasis full of spring water in the middle of a desert, drinking from which, one realizes that this is not a mirage.

My intention is not to make this article about myself, although I must present it that way to make it personal. Instead, it is a brief introduction to an ancient mystery which has been accompanying humanity from time immemorial, echoing through millennia while reaching out to the new hearts and minds.

Free from ideology and dogma, the ancient path remains intact and clearly drawn on the map of consciousness. The daily miracle of Nature, which gets neglected every day in life, is recognized and worshipped with tears of gratitude. The healing energy of sacred cactus drunk like nectar with the beak of our souls. A light greater than the light of the day is finally seen with the inner eyes and loved for its purity and beauty. Belonging to the greater unity becomes a fact of life, not a wishful experience. The denying of the physical world, which is somewhat needed at the early stages of spiritual path, in order to understand the difference, turns into acceptance and living is now seen as the service to the greater cause.

Why bother? Why would we need this kind of experiences in our lives? Why would we pay for this with our fears we so cherish?

Well, simply put, knowing this reality brings happiness and joy of understanding. That’s really it. There are no more rewards I’m after. Waking up in the morning with a peaceful mind and gratitude for another day in my life is generous gift I am infinitely thankful for.

I think that each of us come to this world with this light, which then somehow vanishes under the sociocultural pressure we acquire during the later years. The loss of it causes fear and anxiety and eventually turns into depression, which is only a symptom of this separation from oneself. We feel alone and lonely. Separated from the source of life, when in fact, we are it, or at least, we are the leaves and flowers of the tree of life.

Reconnecting to our spiritual roots is “coming home”, not in a hyperspace or separate reality surrounded by other beings, but here and now, in our familiar, known space which becomes sacred the moment it is recognized as such.

https://wakeup-world.com/2017/07/17/huachuma-the-visionary-cactus-from-the-peruvian-andes/
 
The Ancient Wonders of the San Pedro Cactus

by Tyson Curtis | Flora Grubb Gardens | 9 Apr 2021

The popular cactus Echinopsis pachanoi (syn. Trichocereus pachanoi) is known by many names, most commonly ‘San Pedro.’ This cactus is fairly common, and no doubt you’ve seen it around—we often have it in stock here at Flora Grubb Gardens, our San Francisco nursery!—but if you dive deeper there’s so much to learn.

Echinopsis pachanoi grows in rocky, well-drained soil along the entire length of the Andes mountains, stretching from Argentina to Ecuador. A high altitude native (6000-9000 feet), this plant thrives in cold climates down to 15 degrees F.

Any cactus grower will tell you that a minimum temperature guideline usually means “when dry,” but not so with San Pedro! Most cactus get rainfall during their warm season, and so are likely to fail when exposed to a wet winter, even if they can tolerate much colder temps in habitat—but San Pedro, in its mountain habitat, receives ample rainfall while still enduring quite cold temperatures. This makes it one of the best candidates for a Mediterranean climate (like ours in the Bay Area). It just needs a bit of additional summer water to thrive.​

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The history of San Pedro is intertwined with Andean culture and traditional medicine, with archaeological evidence showing healers using the plant for religious divination as far back as 3000 years ago.​

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We love Echinopsis pachanoi for its ornamental uses in the garden. As a sturdy vertical design element it’s second to none, able to fit into tight spaces and growing 10-20 feet tall. A single stem will pup and branch, creating a staggered clump of fast-growing spires with a well-balanced form. Unlike other columnar cactus, San Pedro is relatively unspined, increasing its usefulness around patios and walkways, in pots and even indoors in a sunny spot.​

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Since these plants are native to a higher rainfall area, they will tolerate overwatering, with good drainage, making them easier to intermingle with other plantings, allowing designers to set softer plants against them for contrast. In fact these cactus prefer even watering, especially during the dryer months. About the only problem we encounter is yellowing, which happens when people relinquish water entirely, plant in heavy clay, or never fertilize. San Pedro appreciates fertilizer more than other cactus and will reward you with fast growth and vibrancy.​

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Maybe the most notable aspect of Echinopsis pachanoi are the huge white flowers, found in abundance on established specimens. These fragrant flowers are tubular and almost ten inches long and wide! The unusual size relates to the overly-large hummingbirds that pollinate them in the Andes, though they are also moth-pollinated. Since the pollinators are nocturnal, you’ll find that these huge white flowers open at night, making San Pedro an ideal candidate for a moon-viewing party in your new garden!​

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We grow this plant ourselves down at Grubb & Nadler Nurseries in the gorgeous Rainbow Valley, so we often have it in stock here at FGG. Come see us soon!

Visit us at Flora Grubb Gardens in San Francisco to see our wide selection of interesting cactus plants.

For more of this kind of inspiration, delivered to your inbox, join our mailing list.
 
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Mescaline as Therapy

by Dave Hodes | Green Market Report | 10 Feb 2022

The exploration of other types of psychedelics is common now, with MDMA, 5-MeO-DMT (toad venom), LSD all getting attention for different mental health treatment studies and different therapeutic interventions.

But mescaline, derived from either the San Pedro cactus (native to the Andean slopes of Ecuador and Peru), or the peyote cactus (found in the limestone soils of the Chihuahuan desert of southern Texas and northern Mexico) stands out as a different kind of psychedelic off the radar of the psychedelics industry—so far.

Though some research has examined the effects of mescaline in humans—for instance, Alexander Shulgin’s work in the later part of last century—clinical research investigating mescaline as a potential therapeutic aid has been lacking.

There are problems about working with mescaline. For example, to get the full effect of the San Pedro mescaline, it is estimated that someone would have to eat 750 grams of slimy, bitter plant material.

As derived from either plant, mescaline is physically difficult to take. Experiences and outcomes are harder to predict, and generally take too long from start to finish. But researchers know there is something significant here to discover and bring into the psychedelics industry.

Like many other psychedelics, mescaline has a long history of use. Indigenous people in North and South America used it for religious ceremonies dating back 5,700 years. That continues today.

According to “Mescaline: A Global History of the First Psychedelic,” by Mike Jay, a scientific and medical historian, mescaline was isolated from the peyote cactus by a German chemist, Arthur Heffter in 1896, and was the first naturally occurring psychedelic alkaloid to be isolated in a lab.

People who began using it then described bouts of nausea followed by long-lasting uncontrollable hallucinations. They reported experiencing racing heart and difficulties breathing. Depression. Insomnia. Delusions that turned into paranoia.

Mescaline, it seems, developed a bad rap.

Mescaline was eventually synthesized in 1919 by a chemist at the University of Vienna, Ernst Spath, and researchers thought it could help them understand schizophrenia. It didn’t.

Both the Nazis and Americans experimented with it during World War II as a sort of “truth serum.” That didn’t work either.

But there were people who challenged and added to the knowledge base of mescaline, famously Aldous Huxley who described his trip experiences in his 1954 book “Doors of Perception.”

Today, more than 100 years after mescaline was first synthesized, there finally appears to be movement on the question of whether it can be used as another psychedelic plant for mental health treatment.

Native Americans interviewed by Michael Pollan for his book, “This Is Your Mind on Plants,” told him that their peyote ceremonies had done more to heal the wounds of genocide, colonialism, and alcoholism than anything else they had tried.

Peyote is legal for Native Americans. Its use is constitutionally protected in the U.S. on the basis of religious freedom when used by the Native American Church. And it’s these ongoing experiences by native Americans that have become the basis for understanding the effects of mescaline, and a guide for more research.

In 1992, researchers studied the psychological, neuropsychological, and neurometabolic effects of mescaline in 12 normal men as a method of studying psychosis. They found that mescaline produced an acute psychotic state within 4 hours after drug intake.

But was that the best use of this plant medicine? Shouldn’t mescaline get a better chance of finding its place in the booming psychedelics industry as a wellness treatment? Maybe. But there are still a number of practical issues to resolve.

While peyote is considered endangered in some areas of Mexico, it can be freely grown in any greenhouse. But it is a difficult plant to cultivate, and can take a long time to grow in a greenhouse (peyote takes up to 25 years to grow in the wild).

The San Pedro cactus grows rapidly and is not an endangered plant. But not all San Pedro cacti have the same mescaline concentration, and two cacti grown from the same seed pod may have very different mescaline contents. To make estimating potency even more complicated, mescaline content can vary depending on when a plant was harvested or the conditions it was grown in.

Then there’s this: Peyote’s ongoing cultural significance to Native Americans played a role in recriminalizing it in Santa Cruz in 2021 after it was decriminalized two years earlier. Decrim advocates apologized to the Native American Church for their “lack of cultural sensitivity.”

In the meantime, there are a handful of companies taking a shot at mescaline development. Lophos Pharma, a Toronto-based bioscience company recently acquired by Greenridez 2.0 Acquisitions Corp., specializes in peyote research, cultivation, preservation, and drug development, and will be working on treatments using peyote for weight loss, drug addiction, anxiety and depression.

Other leading psychedelics development companies such as Compass Pathways, MindMed, Xphyto Therapeutics Corporation and Numinus are all exploring mescaline product development.

There have been other encouraging developments recently that mescaline may be catching on. For example, there was a slight uptick in clinical studies about mescaline in 2021.

Presumably, with new agri-technology for cultivation, and better research about how the plant grows—perhaps about how to grow peyote faster, or how to control the mescaline content of the San Pedro cacti—mescaline, the first psychedelic, may become tomorrow’s psychedelics superstar.​

But for now, it’s been relegated as a sort of look-see, back-burner problematic substance that needs much more overall research. So.. stay tuned in.

The post Mescaline As Therapy Is Getting Attention, Despite Stigma appeared first on Green Market Report.
 
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Macrodosing Mescaline*

by Jerry Toth

Not all San Pedro journeys are created equal. There are several key variables that influence the quality of the experience. Reaching critical mass with dosage can be the difference between disappointment and ecstatic connection with the fundamental nature of existence. Knowledge about different preparation methods and mescaline potency is useful. As always, the principle of “set and setting” applies. And there’s a few things you should definitely not do.

The suggestions contained in this article are based on seventeen years of personal experimentation in addition to conversations with hundreds of other people who have also experienced San Pedro (otherwise known as Huachuma).

I do not consider myself the foremost expert on this subject. I’m just one of many ongoing students of a sacred cactus that has the power to connect human beings with an immense source of wisdom. By the same token, I welcome feedback from anyone else who has experience with this particular plant. The goal, as I see it, is to collectively refine our understanding about something that is and always will be delightfully mysterious.

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Whether you brew San Pedro tea or dehydrate/grind the flesh into powder, the first steps are always the same: remove the spines and outer skin (bowl on the left), extract the green flesh (bowl on the right), and disregard the white core (bottom). Only the green flesh is used for processing and consumption.

Not all San Pedro experiences are created equal

Extensive conversations with a broad sampling of other San Pedro explorers led me to a surprising realization. This process started in 2018 when I published an article called “DIY Mescaline: How to explore San Pedro without a guide.”

I eventually included my email address in the article and asked people to contact me if they’d like to see the final cut of a film we’re currently making about San Pedro in its native land. Many of the people who responded were kind enough to share with me their own personal San Pedro experiences, and we developed a back-and-forth dialogue.

What didn’t surprise me was that most people described their experience in glowing terms. What did surprise me is that a decent number of people described their experience as disappointing. I followed up with questions about set, setting, preparation method, and dosage. And I started to recognize an interesting pattern.

I entered into this discussion with the perspective of someone whose experiences with San Pedro were exclusively profound and transformative. One journey inspired the creation of a large-scale rainforest preserve, and I don’t even consider that journey to be my most formative. A disappointing Huachuma experience was hard for me to imagine, at first. But now it makes sense.​


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The most common complaint

As Timothy Leary first explained about fifty years ago, the nature of any psychedelic experience is determined by set and setting. “Set” represents all of the variables that you personally bring to the experience — your mindset as well as your accumulated life experiences, your psychology, even your neurobiology. “Setting” represents the conditions in which the psychedelic experience takes place. To these two primary factors, I would also add two more: the quality of the substance (call it medicine, if you wish) and the dosage.

Of all four of these factors, set is the hardest for me to measure in others — my access inside the hearts and minds of other people is limited. The matter of setting is a bit more straightforward. I comment on this with greater detail in “DIY Mescaline.” The quality of the medicine depends on a range of variables, which I discuss below. All of the above factors can be managed with a bit of experience.

The factor that was most frequently at the root of sub-par San Pedro experiences was dosage. Namely, the dosage was too weak. By far the most common complaint was that the medicine simply didn’t have much of an effect. People felt like they missed out on the experience. And to a certain extent, they did.

The danger of under-dosing

Sometimes a light dose of San Pedro is advisable. There are some reputable San Pedro retreats in which people are given a moderate dose and then taken on a group hike to some beautiful place. In this case, the moderate dose is intentional: people still need to be able to walk. In other cases, the moderate dose was administered in a traditional sit-down ceremony. For some people in some circumstances, this is also the right approach. It allows people to dip their feet into the experience without going too deep.

For other people, however, the experience wasn’t strong enough. I am merely reporting what numerous people have told me. They consumed just enough San Pedro to feel a bit funny in the stomach and start to perceive things somewhat differently, but the door to Huachuma World did not fully open. They remained firmly planted in the so-called default world.

This is a lost opportunity. I do not mean to discount the practice of micro-dosing San Pedro, which is also something I’ve extensively experimented with. You can read about that in my article “Micro-Dosing Mescaline: Comparing San Pedro to LSD and Psilocybin.” It can certainly be a useful practice, but it still doesn’t compare to the profound lessons that can be deeply learned on a full dose of Huachuma. It is the difference between briefly kissing someone at a doorway versus spending a very long, languid morning making love in bed with the person that you’re in love with.​

Crossing the threshold

After hearing several accounts of weak San Pedro experiences, I did a few experiments on myself. I tried everything from 1–3 grams of dry powder and half an arm of wet cactus, all the way to what I consider much more than a full dose: two arms of a thick, wild-harvested San Pedro from a particular mountain in southern Ecuador.

From those experiences I learned many things that have nothing to do with this article. The main thing I learned, which is relevant here, is the importance of crossing the threshold. In the realm of micro-dosing, there is something called the threshold of perceptibility, but that’s not what I’m talking about. I’m talking about the threshold one must cross to reach the full Huachuma experience. A moderate dose of San Pedro only opens the door ajar, such that you barely catch a glimpse of what’s inside. To actually pass through the door, the amount of San Pedro you need to consume must reach critical mass.

Once critical mass is reached, you’ll know it. It’s like opening your eyes after years of darkness. There is a simple litmus test to help determine whether or not you’ve crossed the threshold. If you feel physically pulled to the ground, lying on your back on the naked ground and staring upwards into the sky, and you are accompanied by the sense that nothing in this universe is misplaced, that everything is exactly as it should be…you made it.

This feeling I describe is not overly intense or uncomfortable. It is deep-penetrating and comprehensive, but at the same time gentle and loving. This, in my opinion and the opinion of many others who have also reached this state, is the special nature of the Huachuma experience at full strength.

Almost all of the mescaline is concentrated in the layer of green flesh, just beneath the waxy outer skin. That’s the only component of the cactus that should be consumed.

Different Preparation Methods

Before we can talk about dosage, we first need to talk about preparation methods. There are several ways to prepare San Pedro for consumption, some of which are less than ideal. The two best methods are:

1. Brewing Tea: Slice away the green flesh and put it into a pot of water, and then boil it down into a concentrated green liquid. This is the method I’ve been using since 2002, detailed in “DIY Mescaline.”

2. Drying/Grinding into Powder: Slice away the green flesh, cut it into pieces, and dry the pieces using a dehydrator, the sun, or an oven at the lowest heat setting. Once the pieces are dry, grind them into a fine green powder. This is a method I’ve recently been testing. In my experiments, a forearm’s-length of cactus (38cm long by 8cm diameter, weighing 1.38 kg when freshly harvested) yields about 20 grams of highly concentrated dried powder. See below for mescaline calculations.

In both cases, you’ll start with a fresh cutting of cactus. And in both cases you will want to remove the spines and the waxy outer skin. You should also exclude the white pulp that is underneath the green flesh. Several YouTube tutorials show people including the white pulp in their process, usually with a blender, but this is not advisable. The white pulp has a negligible amount of mescaline, and furthermore is the leading cause of nausea. Whichever method you use, the only part of the cactus that you should process is the green flesh.​


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Sun-drying the flesh of an arms-length section of San Pedro on a rooftop in Quito. After fully drying and grinding the pieces, the final result was 20 grams of fine green powder.​

Length of cactus per dose

The right dosage required to reach the full Huachuma experience depends on many factors. It depends on where and how the cactus was grown, which variety or cultivar it is, and your own body weight and other physiological and psychological factors.

Nevertheless, there is a general rule of thumb that I’ve always abided by and it has never failed me. Here it is: use a piece of cactus that is roughly the same length and girth as your own forearm, as measured when your hand is balled up into a fist. Personally I consider this the minimum size for a normal dose, and I usually use a piece that is slightly larger than my forearm. But for the sake of this article, I will refer to a forearm-sized piece as a “normal dose.” All things equal, this is the dosage required to cross the threshold. If the dehydration method is used, this generally equates to about 15–20 grams of dry powder, depending on the size of your forearm.

This, however, assumes that the cactus you’re using is suitably potent. Mescaline potency varies from cactus to cactus. Interesting enough, San Pedro is influenced by terroir just as much — if not more so — than wine and cacao.


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20 grams of fine green San Pedro powder — the yield from one 15 inch (38 cm) length of cactus, roughly 6.5 cm in diameter and originally weighting 1.38 kg when freshly harvested.​

Mescaline potency

San Pedro is inherently more predictable than Ayahuasca because it only involves one plant. Ayahuasca, on the other hand, involves at least two psychoactive plants, if not three or four — all of which produce different kinds of effects. Thus, San Pedro is a lot harder to screw up and requires less experience to prepare.

Nevertheless, mescaline potency can vary. Erowid has a useful mescaline potency FAQ that illustrates the variability between species of cacti (San Pedro, Peruvian Torch, and Peyote) and between individuals within each species. The “average” potency of San Pedro is generally regarded as 1% mescaline per dry weight. However, some San Pedro cuttings have measured as little as 0.1% mescaline, and the most potent cuttings measured as much as 2.3% mescaline.

Short of testing the mescaline content in a laboratory — which is not an option for most of us — the most reliable way to test the strength of a particular cactus is to start by consuming a piece that is 1/2 or 2/3 the length of your forearm. After two and a half hours, if not sooner, you’ll have a good idea of what you’re dealing with.

Once you’re familiar with the potency of a particular cactus, it’s preferable to consume most of your entire dose at the beginning, and then top it off within the first few hours — if necessary. The whole experience can last 12–16 hours during normal circumstances, which is already quite long. So you don’t want to unduly prolong the ingestion process.

Can physical cues be used to gauge the potency of a given cactus? Different sources give different answers to this question. Some San Pedro experts suggest that potency may be enhanced when the plant is subject to environmental stress caused by adverse temperature, sun, water, soil, or pest conditions.

All of this said, a low dose of San Pedro is not the end of the world. If you don’t cross the threshold during a particular journey, it’s okay — enjoy it for what it is. But you’ll probably want to consume a larger dose the next time. Now you know.​


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On the subject of “set”

It’s natural to feel some fear or trepidation before a psychedelic experience, but if your fear is intense, it’s probably a signal that you’re not ready for this journey. And that’s okay. Timing is important.

In any event, a plant like San Pedro should never be used as a tool of escape. Rather, it is best consumed in the spirit of discovery. That said, San Pedro can be tremendously useful when working through post-traumatic stress disorder. I’m speaking from first-hand experience. It can also be extremely useful for those who are working through depression, addiction, and fear of death.

If you suffer from psychosis, however, you should probably not ingest San Pedro or any other psychedelic substance. There are plenty of other methods that can be used to learn more about self and the universe.​

On the subject of “setting”

My personal preference is to consume San Pedro alone or with one or two other people. I have spoken with several people who feel similarly. There are also plenty of people who prefer to consume San Pedro in a group setting, often guided by a shaman or guide. Both of the above formats can work wonderfully; it’s a question of personal preference and temperament.

If you do wish to work with a guide, do your research and choose wisely. I would suggest meeting the guide before you commit to anything, so that you can consult your intuition. Different guides have different energies, and what may resonate with some people may not resonate with you. Be especially weary of charlatans and sexual predators. Here’s a good article about that.

The same principle applies to the actual setting. You do not want to go on a San Pedro journey in a place that doesn’t feel good. And for the love of all things holy, please do not consume San Pedro in a city. San Pedro and cities do not mix well. It is absolutely imperative that you are surrounded by the natural world.​
 
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How to grow and care for San Pedro*

by Miruna Secuianu | Garden Beast | 5 Aug 2020

San Pedro cactus is a very easy-to-grow and popular columnar cactus. Natively found in South American countries like Peru, Chile, Bolivia, and Ecuador but grown in other parts of the world as well, this impressive cactus is quite fast-growing and it can reach up to 20 feet (3m) in height.

This ornamental cactus has been used for thousands of years in traditional medicine and shamanic rituals in South America so it comes as no surprise that it has over 25 different names such as andachuma, huachuma, achuma, aguacolla, giganton, hahuacollay, to name a few.

Cataloged by Dr. Joseph Nelson Rose, an American botanist, who named it after Eng. Abelardo Pachano Lalana, a renowned Ecuadorian botanist, San Pedroi is full of surprises. It contains mescaline, a controversial psychedelic which is illegal in the US, where the plant is sold solely for ornamental purposes.


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Growing, caring for and propagating San Pedro is fun and rewarding, for beginners and experienced cacti growers alike. The San Pedro cactus thrives at high altitudes, such as the Andes Mountains, where it can be found at altitudes of 6,600–9,800 feet (2000-3000m).

When grown outdoors, the San Pedro cactus can withstand temperatures as low as 48.2°F (-9°C) and it prefers temperate climates, plenty of light, and fertile, well-draining soil.
  • San Pedro cactus is native to Peru, Ecuador, Argentina, Chile, and Bolivia and it thrives at high altitudes, in the Andes Mountains.​
  • It can be grown outdoors in USDA Hardiness Zones 8b to 10b as it doesn’t mind cooler temperatures as long as they don’t drop below 15°F (-9°C).​
  • San Pedro cacti need a lot of natural light and mature plants don’t mind being in full sun. Seedlings, however, are a bit more sensitive and can suffer sunburn.​
  • When grown indoors, these cacti need well-draining soil and if they cannot get enough natural light you might have to invest in some grow lights.​
  • Like all cacti, San Pedro loves light and warmth. However, this cactus prefers soil that’s a little more nutrient-rich than regular cacti soil mix.​
  • Natively-found at high altitudes, this cactus might require more water, especially on hot summer days.​
  • It is a fast-growing cactus that’s been used in South American traditional medicine and religious rituals for centuries. Like Peyote, San Pedro contains mescaline, an illegal psychedelic similar to MDMA.​
  • While consuming San Pedro cacti is illegal in most countries, growing it is not, so it’s perfectly safe to decorate your home or garden with these amazing plants.​
  • The San Pedro is moderately poisonous, so you should keep is within a safe distance from children and pets.​

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  • San Pedro cactus is a large columnar cactus that grows relatively fast. Depending on their growth environment, San Pedro cacti can grow up to 12 inches (30 cm) per year.​
  • This multi-stemmed cactus can reach up to 19 feet (5-6 meters) in height and 6 feet (2 meters) in width.​
  • The thick individual stems of the San Pedroi are green or blue-green and they become darker with age. They have between 4-8 ribs each and can be 2.4-5.9 inches (6-15cm) thick.​
  • In July, the pointy buds of the San Pedro cactus produce beautiful whitish flowers which open at night, have a pleasant fragrance, and measure approximately 8.7 inches (22 cm) in diameter.​
  • The edible fruits of the San Pedro are called Pitahaya and are red-skinned, scented, sweet, and tasty.​
  • It is closely related to Trichocereus peruvianus aka the Peruvian Torch Cactus. In fact, these two cacti are so similar that their names have become interchangeable and it’s pretty much impossible to tell them apart if you’re not a specialist.​
  • San Pedro cacti pair well with Senecio mandraliscae, Aloe cameronii, Phormium tenax, and Agave truncata.​

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Growing San Pedro is easy especially since this versatile cactus is very forgiving and only needs a little water and some nutrients. The best thing about San Pedros is that they don’t mind cold weather as long as the temperatures don’t drop below 15°F (-9°C). So, if you live in a temperate region, you won’t have any issues with growing San Pedro cacti outdoors.

In its natural habitat, this cactus gets a lot of natural light and its soil is more nutrient-rich than the regular cacti soil mix. If you grow this cactus in a container, you can feed the soil a little, but not too much, because it’s still a cactus.

Cacti don’t need a lot of water to grow healthy and happy, but just like any other plant, they do need some care, love, and attention. When growing San Pedro indoors, make sure you place it on a well-lit window sill, preferably on the south-side, and water it more often on hot summer days.

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Hoffman Organic Cactus and Succulent Soil Mix,
From Amazon

As mentioned above, these cacti grow relatively fast, especially if they are acclimatized to their growth environment, they are planted in good soil and watered more often throughout the warm summer months. Mature, established plants can grow 11-12 inches (30cm) in a year.

San Pedro cacti are quite susceptible to fungal infections such as witches broom disease and orange rot, especially when they are overwatered. If you suspect that your cactus has a fungal infection, make sure you remove all the affected parts with a clean knife. If the plant has too many lesions, it might be better to take a few healthy cuttings and start a new plant. In general, fungal outbreaks can be prevented if the cactus has well-drained soil, plenty of heat, proper ventilation, and a sterile medium.

Other common pests that can affect San Pedro include scale, spider mites, and root mealybugs all of which can be easily removed with neem oil or simply scrubbed off if the plant isn’t severely affected.

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San Pedro cacti prefer a dry environment and, like most cacti, they are very sensitive to overwatering, which is the number one cause of cacti demise. Because they naturally grow in the Andes Mountains, at high altitudes, San Pedro cacti thrive in temperate environments, so if you live in USDA Hardiness Zones 8b-10b, you can grow these beautiful ornamental plants outdoors.

When planted outdoors, San Pedro cacti will need more frequent watering in summer, and minimal watering in the cold winter months. Cold temperatures can prevent the water from evaporating, and your cacti might sit in damp soil for too long. This, in turn, can lead to root rot, which must be avoided at all costs.

A major difference between San Pedro and other cacti is the fact that it requires some nutrients from time to time. You can purchase specific cacti nutrition that has high amounts of phosphorus and potassium, and low amounts of nitrogen. The ideal NPK value for cacti fertilizer is 4-7-7 and 2-7-7.
You can easily propagate San Pedro cacti from offsets, which grow abundantly around the base of the mature plants. To remove the offsets safely, make a clear cut with a sharp, clean knife as close to the stem as you can. Place the fresh cutting on a piece of paper and let it dry out a little, cut it at the narrowest place possible, and let it callous for a few days. Once the cutting has calloused, you can safely place it in a container with drainage holes and well-draining soil.

If you plan on repotting your San Pedro, it’s best to do it during the warm season. Before repotting, the soil should be dry to prevent damaging the roots. Remove as much soil as possible and clean any rotten or dead roots in the process. Keep an eye out for pests and diseases and treat any cuts with a fungicide. Put the plant in its new container and spread the roots as much as possible while adding fresh cacti soil mix. Let the plant rest in dry soil for a week and then start watering it lightly until the plant adjusts to its new environment.

San Pedro have stiff spines, so you might want to wear gloves while handling these plants.​
Growing San Pedro is fun and rewarding because these friendly giants grow faster than other cacti and they produce beautiful flowers and edible fruit. To grow healthy and happy, they need well-draining soil, plenty of natural light, and a little water once in a while. You can grow them outdoors if you live in a temperate region, as long as the winters are not extremely cold.

San Pedro cacti make amazing ornamental plants, but they are also rich in mescaline, a psychedelic substance, so consuming these plants is illegal in many countries. Growing them as ornamental plants, however, is perfectly safe, but you should still keep them away from children and pets.
 
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Ultimate Guide to San Pedro

Reality Sandwich | Oct 6 2019

Echinopsis pachanoi, commonly known as San Pedro, is a cactus that contains a wide variety of psychedelic alkaloids. While the primary active ingredient is Mescaline, this cactus has some minor differences due to the other psychedelic alkaloids it contains. The San Pedro cactus naturally grows throughout the Andes mountains in Argentina, Bolivia, Chile, Ecuador, and Peru.

Also part of the Echinopsis genus is the Bolivian Torch and Peruvian Torch. These cacti are commonly confused with San Pedro due to their similar effects and appearance. They are so similar that they are all referred to as San Pedro in Spanish because of their psychoactive effects. There are however slightly different alkaloid compositions between these three species so the psychedelic experience will be different depending on which specific species you take.

Overview

San Pedro produces a psychedelic effect when consumed in activating multiple psychoactive compounds within the cactus. The primary active compound is mescaline, so the effects are very similar to pure mescaline but not the same. Due to the wide variety of psychoactive alkaloids contained in the cactus, many users report an effect akin to a stimulant as well as a psychedelic experience. The entire San Pedro experience typically lasts around ten hours.

The San Pedro cactus has been used in healing and religious ceremonies for over 3,000 years by shamans in the Andes mountains. It only grows at specific altitudes, between 6,500 and 10,000 feet, making it difficult to obtain in ancient times. The Andes shamans would grind up the cactus in a ritual bowl until it was a slushy liquid. It would then be passed around to the members of their group that were a part of this ceremony. These ceremonies would last the entirety of the night and sometimes they would hold them multiple days in a row.

The most common native name for the San Pedro cactus is materia prima which translates to “the primordial soup of the cosmos.” This name alone shows the importance that the San Pedro cactus carried in the eyes of the Andean shamans. Another name for this cactus is huachuma which translates to “removing the head.” This name comes from the belief that the San Pedro cactus can shed away your predispositions and bring you closer to heaven. Similar to the Spanish translation of San Pedro, Saint Peter was a Catholic Saint believed to hold the keys to heaven. Other names for this cactus include achuma, wachuma, aguacolla, hahuacollay, and giganton.

The scientific name for the San Pedro cactus is Echinopsis pachanoi. On average an Echinopsis pachanoi cactus’ chemical composition is roughly 90% water, 0.71% mescaline, and trace amounts of 3,4-DMPEA, 3-methoxytyramine, and tyramine. The other Echinopsis species contain similar amounts of water, but different amounts of psychoactive alkaloids. Echinopsis peruvianus contains 0.3% mescaline, and trace amounts of 3,4-DMPEA, primary and secondary amines, free phenolics, triterpenes/steroids, catechins, 3-methoxytyramine, and tyramine. The Echinopsis lageniformis contains 0.76% mescaline, and trace amounts of 3,4-DMPEA, 3-methoxytyramine, and tyramine. Despite the primary active ingredient in all three of these cacti being mescaline, they will all have slightly different effects due to the various other psychoactive alkaloids they contain.

Forms, methods of consumption

As with most psychedelic cacti there are a lot of different ways San Pedro can be consumed. The most common way in modern times is to dry it then grind it up into a powder and either put it in capsules or dissolve it into a drink. Putting the dried powder into a capsule is the easiest method since you won’t have to deal with the bitter taste San Pedro is known for. Stirring it into a drink can also help mask the taste.

A more traditional way of preparing San Pedro is by either brewing it into a tea or grinding it up into a slushy liquid. To prepare a tea or a slushy liquid, first cut it into thin, horizontal slices. It will look similar to a cut up kiwi. Then blend the slices up into a slushy liquid. From here, the slushy pulp can be consumed or it can be boiled down then strained into a tea.

Determining dosage is complicated due to the unknown amount of active alkaloids in the cactus. There can be large variances in the amount of mescaline and the other psychoactive alkaloids within San Pedro. An active dose can be anywhere from 20 to 50 grams of dried cactus skin. To make things even more complicated, the various parts of the cactus also have different concentrations of psychoactive alkaloids. The layer just beneath the skin is considered to have the highest concentration of active compounds.

Pharmacology

The primary psychoactive compound in the San Pedro cactus is mescaline, but it also contains a wide range of other psychoactive compounds in varying amounts. Mescaline is a psychedelic compound that produces visual and auditory hallucinations as well as a distorted sense of time and an altered thought process. This is caused from the compound’s similarity to the neurotransmitters dopamine and noradrenaline allowing it to bind to the 5-HT2A and 5-HT2C serotonin receptors in the brain.

Echinopsis lageniformis and Echinopsis pachanoi differ from the rest of the Echinopsis genus in that they contain higher concentrations of other alkaloids aside from mescaline. These higher concentrations of other alkaloids makes extracting pure mescaline more difficult, and their effects very different from pure mescaline than other mescaline-containing cacti. There is also some speculation within the psychedelic community that Echinopsis lageniformis contains MAOIs which can prevent the breakdown of mescaline within your body. The purest source to extract mescaline from would be the Echinopsis peruviana due to its relatively low levels of other psychoactive alkaloids.

It is becoming increasingly difficult to track the alkaloid content in the different species of Echinopsis because breeders have been crossing the lageniformis, pachanoi, and peruviana species. This creates hybrid species that have large variations in their alkaloid content. One of the hybrids from this cross breeding is commonly referred to as pachanot. It is nearly identical to the pachanoi species except it has very low alkaloid content including mescaline. The pachanot is the species that most cactus flower shops in the United States sell as the San Pedro cactus. Due to the low alkaloid content, there will be very little to no psychedelic effect if consumed.

Common side effects

According to the Center for Substance Abuse Research, common side effects of San Pedro include:

- Increased blood pressure and heart rate
- Loss of appetite
- Increased body temperature
- Impaired motor coordination
- Dilated pupils
- Heightened senses
- The perception of seeing music and hearing colors referred to as Synesthesia
- Hallucinations
- Loss of your sense of reality

When consuming psychedelic plants, there is a likelihood that they will cause what the psychedelic community calls purging. This typically occurs during the onset of the effects as vomiting or diarrhea. While this won’t occur for every user, being aware of this possibility will reduce the nervousness it could cause during a trip. A psychedelic experience could also make speaking and having sexual intercourse more difficult. One should never drive or use heavy machinery while under the effects of a psychedelic substance as it will distort your perception of space and time.

Trends

The most popular hybrids within this unique community of cactus growers is Juul’s Giant, Chemical Shaman’s Dick, and SS02. Juul’s Giant is a subspecies of the Echinopsis pachanoi. It has an especially large girth that’s nearly double the size of a standard Echinopsis pachanoi. This subspecies was created in Tom Juul’s backyard garden in San Francisco and all legitimate clones of this subspecies originated there.

Chemical Shaman’s Dick, or CSD, is a subspecies of the Echinopsis lageniformis known for its stunted but “girthy” size. It also has unique spines that are very different from other Echinopsis lageniformis. This gives it a very unique appearance that has grown very popular within the cactus enthusiast community. It has become so popular that there are even shirts available with a picture of the top-down view of the cactus.

The SS02 cactus is also a subspecies of the Echinopsis lageniformis created by Ben Kamm at his nursery Sacred Succulents. It is known for its large size growing up to 16 feet tall and with relatively short spines. The short spines cause it to grow very unique offspring. This is a very hardy subspecies so it is a great option for beginners wanting to get into growing cacti.

Around the world

Retreats in South America are a growing trend where tourists attend San Pedro ceremonies. This has become a growing industry in South America. Curious individuals can have a traditional San Pedro experience within Native communities. There is concern that if these retreats grow in scale there will be issues with over-consumption of the plant. This over-consumption happened with the Peyote cactus, resulting in it being classified as an at-risk species. It is still unclear if this will become an issue as the San Pedro grows back at a much faster rate than the Peyote.

The San Pedro cactus lasts an extremely long time if properly dried prior to storage. A fresh cactus can grow mold at a similar rate as common fruits and vegetables. The Alkaloids within the San Pedro do not degrade into toxic compounds.

How to store San Pedro

The San Pedro cactus lasts an extremely long time if properly dried prior to storage. A fresh cactus can grow mold at a similar rate as common fruits and vegetables. The Alkaloids within the San Pedro do not degrade into toxic compounds. Proper storage of San Pedro includes drying the cactus then storing in a cold, dark, and dry location. When stored properly the cactus can last for thousands of years and still contain Mescaline.

What does San Pedro taste like?

San Pedro has an extremely bitter taste due to the alkaloids it contains. Folklore originating from the Native communities in the Andes Mountains says a pure heart will not taste the bitterness. If you are aware of the bitterness and expect it, it will be less likely you will gag and potentially vomit from the taste.

What does San Pedro look like?

San Pedro has a light to dark green color with a diameter between 2.5 to 6 inches. They typically grow to heights of 10 to 20 feet with multiple branches. The tallest recorded San Pedro cactus grew to 40 feet tall. There are typically between six and eight ribs on a mature cactus. It produces yellow to brown spikes that can be up to an inch long. When it is flowering it grows white flowers at the end of its stems that open up at night. The color and shape of the flower is important in identifying which species the cactus is. After fertilization a San Pedro cactus may produce dark green fruit.​
 
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How to explore San Pedro without a guide

by Jerry Toth

San Pedro (Trichocereus pachanoi) is a cactus native to the Andean slopes of Ecuador and Peru. It is the South American cousin to peyote, and most notably contains the psychoactive alkaloid known as mescaline. It’s a plant I’ve been working with for over sixteen years by now, strictly in-situ in Ecuador and always wild-harvested. No, I do not claim to be a shaman. I’m just someone who knows a very reliable way to prepare this cactus for consumption and who has a few insights to share about its usage.

In recent years, there has seen an explosion of interest in Ayahuasca and, to a lesser extent, San Pedro. Both of these plant medicines are found in Ecuador. In fact, wild San Pedro cactus grows only a few hundred kilometers from the native range of the Ayahuasca vine and its various DMT-containing companion plants such as Chakruna. Whereas Ayahuasca and Chakruna are lowland Amazon species, San Pedro prefers the mid-elevational valleys and slopes on both sides of the Andes. In Quechua, it’s called Huachuma or occasionally Wachuma.

Like Ayahausca, San Pedro has been used for healing purposes and to open doors in the minds of people for thousands of years. Only recently have these plants found their way to a broader audience in distant countries. As of a few years ago, I was the only person I knew who had consumed San Pedro, and now I know a few dozen people who’ve tried it. However, all of these people have only tried it as part of a collective ceremony, usually administered by a guide in a land far outside of San Pedro’s native range. I have nothing to say against that way of doing it, because I’ve never done it that way. I’ve only done it my own way, from wild cacti that I harvested and prepared myself and consumed by myself. For those of you interested in exploring San Pedro in this way, here’s what I can tell you.

If you wish to find San Pedro growing in the wild in Ecuador and Peru, there are plenty of places to do it, but it does take some searching. Your best bet is the eastern slope of the Andes, within the elevational range of 1,800 to 3,000 meters above sea level. Fortunately it’s not like trying to distinguish psilocybe mushrooms from poisonous look-alikes. To the untrained eye, there are a few other species of cacti that vaguely resemble San Pedro, but once you’ve trained your eye, it’s a fairly easy cactus to distinguish. Pictures and detailed descriptions of San Pedro are readily available on Wikipedia, Erowid, and other online resources.

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It bears mentioning that you don’t have to venture to Ecuador or Peru to find this cactus. San Pedro is cultivated and sold as an ornamental cactus in many parts of the US, particularly in the southwest and western states. The cactus itself can be legally purchased in florist shops and tree nurseries in these regions, and it is widely grown in gardens in the Ecuadorian cities of Quito and Cuenca and the Peruvian city of Cusco, to name just a few.

I know of a few people who have prepared and consumed garden-grown San Pedro. The domesticated cultivars are also well-endowed with mescaline — supposedly representing 1% of it’s dried weight, the same as wild San Pedro — although I wonder if the experience would be different. My sense is that it would be different, to some extent, but I really don’t know. If anyone has any information on this, I’d be interested to hear from you.

I first traveled to Ecuador in 2002 and I’ve been living there, for the most part, since 2006. All of my experiences with San Pedro have come from cacti harvested from a single valley in this country. The first time I did it, in 2002, I really didn’t know what I was doing. I was staying at a beach in Ecuador and I randomly met a Peace Corp volunteer who told me about San Pedro. She told me that someone explained to her the entire process, and she followed the instructions and did it by herself and it was the single greatest experience of her life. She verbally passed on these instructions to me, and a few days later I left the beach and headed east across the Andes and went to the exact same place she told me to go and I did everything more or less the same way she explained to me. And everything she said was true.

My entire relationship with this woman was limited to this conversation. I didn’t write down her name or her contact information and we never stayed in touch, so I have no way of thanking her. All I have is the knowledge that was passed down to her and that I am now passing down to you. The only detail I won’t share is the name of the specific valley. But you’ll be able to figure it out if you investigate the matter further.

Once you get there, or wherever you find it growing wild, give yourself an entire day for harvesting and preparation. Start by hiking up into hills in the morning, and bring a knife and backpack. Wild San Pedro cacti can grow to great heights for a cactus — more than twice the height of a tall man, with as many arms as a small tribe of people. Once you find a cactus that feels right, it is customary to first ask permission to harvest one of its arms. It’s a cactus, so it won’t answer you in human language. But I feel like the asking is important.

Choose an arm that is the size of your own forearm, as measured from your elbow to the end of your balled-up fist, and roughly the same girth. I personally err on the side of slightly larger than this, but not much larger.

Put the arm-length segment of cactus in your backpack and hike back down to wherever you’re lodging. Ideally, you’ll want to lodge in a place where you have free reign of the kitchen for about seven hours. That’s the time it will take you to prepare the cactus and boil it down. The only equipment you need is a knife, a stove, a pot, water, and a strainer. Anyone can do it.

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The first step is to remove the spines from the cactus. Use the tip of a small knife for this. Remove each spine, one by one, and discard them. The second step is to remove the thin, semi-translucent waxen layer of skin that encases the cactus. It’s almost like removing dead skin that’s starting to peel after a sunburn — which I say only to illustrate how thin this layer is and also how it is best removed. Use a knife to get under this thin waxen layer and peel it off, and then discard it.

Once the waxen skin is removed, a layer of wet green pulp will be fully exposed — and this is what you want. This layer of green pulp only extends a few millimeters deep. Below the green pulp is a layer of white pulp. Use a knife to remove the green layer, but not the white layer. Inevitably, some of your green cuttings will include some of the white layer, and this is okay. The white layer won’t hurt you — it just doesn’t taste very good and it’s not rich in mescaline. Most of the mescaline is stored in the green layer, so this is what you want to focus on. Try not to miss any of the green — you want all of it.

By the end of this process, you will have a bowl full of green shavings of cactus. Imagine if you were shaving the external part of a carrot, but instead of using a vegetable peeler, you use a knife, and thus your shavings are slightly thicker. That’s pretty much what the green shavings will look like, in terms of their size and width.

Put these shavings into a big pot with about one liter of water, and put this pot over a medium flame for three hours, stirring occasionally. After three hours, you will have about one cup of green liquid. Pour this concoction through a strainer and let the liquid cool.

But you’re not done yet! Put the cactus shavings back into the pot and add another liter of water, and do a second boiling. For the second boiling, I always only do it for two hours, and this has always worked, so that’s what I recommend. Once the two hours are up, pour the liquid through a strainer and mix it with the first batch of liquid. After a combined five hours of boiling it down, I usually end up with approximately 0.5 liters of green liquid in total. If you end up with a little bit more or a little bit less, I wouldn’t worry about it. The important thing is to reduce the liquid for several hours over a fire, because this is what you’re going to drink.

Note: this is not the only way to prepare San Pedro cactus. I know of one technique that employs a blender and another technique that involves drying the pulp and grinding it into a powder. All of the above work, but the method I use has worked so perfectly for me, every single time, that I see no need to deviate from it even to the slightest degree.

Once I’ve finished boiling down the potion, I let this sit overnight. I eat a light, healthy dinner and get a good night’s sleep. The journey will begin the following morning.

This brings us to the matter of set and setting. It is absolutely imperative to choose a beautiful, peaceful, and secluded place outside. You’re basically going to spend the entire day making love with the natural world, so choose this place very wisely. You want it to be a place where it’s comfortable to do things like lie down on the ground and kiss flowers and stuff (seriously). It’s okay to have a house or hut or tent nearby, to serve as home-base during the more reflective second half of the experience. But even your shelter should feel open and connected to the outside. In my opinion, consuming San Pedro in an urban and/or indoor environment is a terrible idea and I very strongly advise against this.

I would also advise against doing it in a public park. You’ll want to choose a place where you’ll be alone or in the company of only those people who you intend to do this with. You will not want to interact with any random “outside” people during the entire process, nor will you want them to be looking at you while you’re staring at tree bark, etc.

I’ve done most of my San Pedro experiences by myself, which was ideal. One time I did it with one other person, and this was also a very special experience. However, I’ve never done it with a group or with a guide/shaman. A couple of times I’ve been invited to do it with a guide, but I always end up turning it down. I’m sure it would still be a remarkably positive experience, and for some people a guide is probably the better way to do it. So I’m certainly not recommending against the use of guide. Over the years I’ve just developed my own process and it’s always worked so perfectly well that I just don’t see any need to change it. It’s a personal decision.

The subject of ceremonies is an interesting one. Although I’ve never participated in a San Pedro ceremony, I have participated in numerous Ayahuasca ceremonies. In the case of Ayahuasca, I do believe that a group setting and a proper guide is important. I think that ceremony, in its most fundamental sense, is also important. But I question the orthodoxy of group-based ceremonies that I’ve begun to see in the plant medicine community. It brings to mind the difference between Church and spirituality. Can spirituality be experienced inside the interior of Church, while a man sings to you from the pulpit? Yes, for some people it can. But spirituality is certainly not limited to Church, and for some people it is more easily accessed alone.

I’ve also never observed a strict dietas before consuming San Pedro. It’s probably not a bad idea, and if you are inclined toward dietas, I would recommend it, but I don’t believe it’s necessary. At the very least, be mindful of what you eat the day beforehand. Be sure to properly hydrate yourself the day before. During the trip itself, you don’t want a stomach full of water, especially in the morning, but don’t dehydrate yourself either.

This brings us to another another important point. I was surprised to learn that many orthodox San Pedro ceremonies begin at nighttime, similar to an ayahuasca ceremony. I’m sure there is some value to this, but I’m a strong believer in drinking San Pedro in the morning. It’s a 16-hour experience, and you will want to spend much of that time communing with the natural world.

On the morning of the trip, I typically wake up around 7am and eat an extremely light breakfast, mostly of fruit. About an hour later, at around 8am, I drink the first installment of the liquid. San Pedro does not taste nearly as disagreeable as Ayahuasca, but it definitely does not taste good. To help it go down, you can try mixing it with some honey or home-squeezed orange juice or simply chug it. I also don’t drink it all at once. I usually break it up into three installments. At 8am, I drink one third of it, and then give my stomach about a half hour to adapt. Then I drink another third, and wait.

It takes a long time for mescaline to come on. There is a funny line in “Fear and Loathing in Las Vegas” about this, although I assume Hunter S. Thompson was referring to synthetic or powdered mescaline. He certainly wasn’t drinking a wild-harvested San Pedro potion. But the comment rings true.

In any event, don’t worry — it will definitely work. Just be patient. For the first hour or two, you will feel the machinations of a strong medicine in your stomach and throughout your body. I’ve never purged from San Pedro, but it certainly has been known to happen. I always feel some light nausea and something of the restlessness that can be felt shortly after consuming psilocybin mushrooms. But also there is this very interesting sensation that something truly amazing is about to happen. Try to focus on that side of it, rather than the light nausea. It’s not that bad.

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After almost two hours, it starts to come on, and this is a glorious feeling. Once it has started and I feel confident that it’s going well, this is when I usually drink the last third of the potion. I have never declined to drink the entire potion — I always end up drinking all of the liquid that I’ve prepared. I’ve also never felt like I didn’t have enough. The dosage has always been perfectly spot-on, without exception — which is somewhat rare, in the annals of psychedelic exploration.

For the next four or five hours, you will be “peaking.” Even at the peak, I have always found it to be a very manageable and wonderfully positive experience. This is not the case with some guided San Pedro ceremonies that I’ve heard about. I’ve spoken with a few people who felt that San Pedro was too intense for them. Using the method of preparation I outlined above, I’ve never had a negative or even an overly-intense experience with San Pedro. I have had a few unnervingly intense moments with Ayahuasca, but never with San Pedro.

The shamanic/plant medicine community likes to refer to Ayahuasca as the grandmother, whereas San Pedro is said to have more of a masculine energy. I don’t entirely agree with this conception of San Pedro. If San Pedro is meant to represent the masculine side of the energy spectrum, I would describe it as a very gentle grandfather, compared to the tough-love grandmother that is Ayahuasca. But this is just me (and all of us) trying to put an extremely complex process into a tidy little box. I feel like a day spent with San Pedro is like a day spent in the arms of Mother Earth, pressed closely to her bosom…or something like that. Obviously these are all imperfect analogies aimed at describing something ineffable.

My point is that there is no need to fear the San Pedro experience, which distinguishes it from the Ayahuasca experience. Ayahuasca has employed a wide range of methods to teach me what I’m supposed to be taught, and some of those methods were sweet and some of them were forceful. In fact, one of the greatest lessons that Ayahuasca can offer is precisely on the subject of Fear itself and how to overcome it. It does this by simulating Fear while simultaneously giving you the tools to go inside Fear and demystify it — a therapeutically genius tactic, in many ways.

San Pedro does not work this way. It will infuse you with some of the most important messages you will ever receive during your time in this life, but it does so with an infinitely soft and gentle voice. San Pedro prefers to communicate truth through beauty. Beauty and the laws of the natural world comprise its language, and these are infused with an indescribable sense of joy that persists throughout the entire day.

The San Pedro joy is not merely a frivolous feel-good joy — although it certainly does feel good. Rather, it is a deeply-penetrating joy with connective power. For a few hours particularly during the peak, you will probably feel pulled towards the ground. You will want to lie down on the earth and look up at the clouds and at the veins in your hands and at rocks and bugs and any other manifestation of the physical universe, and all of these elements will impress upon you the same understanding. You will feel things just as much as you see them, and everything seems to be the bearer of essential truths that you’ve forgotten and needed to be reminded of.

I’ve never covered my eyes with eye-shades during the San Pedro experience, and frankly I can’t imagine wanting to do that for any great length of time. Once again, I am biased in favor of my own personal methods, and I’m sure the eye-shades-on-a-couch-with-music approach also has its virtues. It just seems to me a squandered opportunity. Your powers of vision are never so acute as they are with San Pedro, and I think it would be a shame to deprive yourself of this element of the experience. (Note to ophthalmology and vision researchers: the short-term enhancement of visual acuity caused by mescaline may be something worth exploring).

By the time mid-afternoon very slowly rolls around (although of course time will have an entirely different meaning), you will probably want to sit up and maybe even walk around and explore the woods and streams a bit, or you’ll be content to mosey around the garden. Then a few hours later, when the sun starts to get low, you’ll enter into the very long and productive backend of the trip, whereupon your task now is to assimilate the flood of sensations and revelations that you just experienced and are continuing to experience.

Even when night comes, the trip will still not be over. For me, this is usually the phase in which I feel a burst of forward-looking wisdom. It is an opportunity to refine your direction in life, to set a new course or simply to fine-tune it. If ever there is a time to establish intentions for the coming year or for your entire life, this is it.

If you’re wise, you have chosen a night with a good moon, and if you’re lucky, the sky is clear. For some reason around midnight I always end up going for a walk in the moonlight. What I do on these walks, more than anything, is bask in a sense of gratitude for not only this blessed day that I have just lived, but for the opportunity to exist as a part of this whole thing.

I’ve noticed that bedtime usually comes around 2am. This is a full 16 hours after the moment that the cactus is first taken into the body, but the experience never feels too long. There is an arc to the experience, which rises and hangs in the heights and then very gradually and peacefully falls. The next morning you wake up and begin the rest of your life.

I only do this about once every five years. I don’t feel the need to do it more frequently than that. I would also say that the most important trip was the very first one. Once you have spent a day with San Pedro, all the power of it never really leaves you. For example, I credit San Pedro with convincing me to make rainforest conservation part of my life’s work, which I am still carrying on to this day. There is currently a 1,600-acre rainforest preserve in Ecuador that was born from my second San Pedro experience. Likewise San Pedro is the reason that I’m not particularly scared of dying, and it’s also one of the reasons that I’m happy to be alive.

San Pedro is probably not for everyone, and anyone who follows these instructions will surely have an experience that is different from the experiences that I’ve had. This is just one person’s account of a human being’s relationship with a legitimately magical cactus and the mystical experience that it has the capacity to unlock. I hope there is someone out there who finds this useful.​
 
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