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Safety concerns about combo: shrooms, MDMA, N2O, K, 5-HTP/Prozac

J

jookie

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I plan on a combo with mushrooms (~3g), mdma (~120mg), nitrous, and k (~70mg) and I want to reduce harm/comedown effects as much as possible. So I'm gonna take some magnesium, tums, vitamin c/b12. Now my real question is this: Prozac or 5-HTP? I read on thedea.org that the claim that prozac helps with neurotoxicity is false while dancesafe says it does help. It's not really a matter of price, just a matter of how effective. Thanks
 
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Well Prozac is an SSRI, so that would basically render your MDMA useless. So I guess 5-HTP then haha. In moderation though. I believe too much can increase the chances of serotonin syndrome which can be fatal. If you want my honest opinion, I wouldn't take either...

EDIT: You should probably make your topic title a little more specific too. You'll get better responses that way.
 
Oh yeah. I would be taking the prozac/5-htp 4-6 hours after ingesting the MDMA if I ever do em.
 
The reason SSRIs like Prozac are thought to block MDMA's neurotoxicity is because they also block the main effects of MDMA. I would go with thedea.org's advice.
 
Leave the 5-HTP for postloading, that's probably better. You can start with it right when you just came down from the MDMA. The Prozac is probably a bad idea with mushrooms and MDMA indeed of only because it can change/decrease the effects to that extent.
Leave the ketamine for when you are a while beyond the peak of the trip, well the peak of both mushrooms and MDMA, maybe like 30-60+ minutes after you felt the MDMA kicking in well. Start with bumps and work your way up with 10-15 minutes in between. Don't know what you plan to achieve with it but see if you want to stretch that 70 mg for longer or make it one good short blast session. I would do the nitrous after the K is coming down from it's most intense effects or when the K has completely wore off.

Make sure to get bottles or water ready for the trip and maybe something like fruit.
You can start taking anti oxidants around the time you take the MDMA or a little bit after that.
Perhaps something like L-theanin is good to keep on hand to relax a bit when things die down.
Optionally valerian for sleep after that, a good natural choice but perhaps not as effective as other sleeping aids.
 
Thanks for the replies, but there is something I'm confused about. Why would taking the prozac 4-6 after the MDMA dampen the effects? Shouldn't the effects of MDMA end by then anyways?
 
Taking Prozac 4-6h after the MDMA will just make you feel uncomfortable, taking it at the same time as MDMA will block the effects. My personal feeling is to avoid taking SSRIs without a damn good reason. Adding them to a polydrug cocktail is asking for trouble, especially when several drugs you're taking are known to interact negatively with SSRIs (mushrooms and MDxx).
 
I wouldn't take either of those. Prozac isn't something you want to be messing around with. I've known several people who take it....you become a zombie, lot's of bad side effects to boot. 5-htp is cardiotoxic....it gets converted by enzymes throughout the bloodstream resulting in as little as 2% reaching the brain. Makes a lot of serotonin floating around where you really don't want it.

Better options would be

- drinking lots of water
- taking some piracetam/aniracetam
- smoking weed (I've seen a study that suggested THC prevented mdma induced neurotoxicity, in part because of it's regulation of body temp)
- eating a lot of lean protein and fruit post roll
- walk for 30 mins everyday
 
mixing mdma and an ssri is asking for trouble. .. best case scenario is no effect and you run the risk of feeling seriously awful.
 
The combo would probably be safe if you DIDNT take the prozac. 5htp might be a better option but even that might be risky in combination with shrooms and mdma. If i was using the 5htp in an attempt to offset neurotoxicity i would just take it on the days afterwards anywho
 
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