Safe dose of oxycodone/apap

[2manyses]

Could someone please tell me the safe dosage limit, for a 200 pound man, prescribed 10 mg oxycodone/325 mg apap?
This is post-surgery, and I am concerned about the acetaminophen dose causing him to have low blood pressure.
His prescription says 3 times a day, but he is sneaking 3 or 4 additional tablets each day.
If I ask his doctor, I am afraid he will take it away from him, and he really IS in serious pain.
Thank you for your help.

 

[Shambles]

Welcome to BL

Recommended daily maximum for APAP/paracetamol/acetaminophen is 4g per day. That's a lot though and probably not a good idea at all longterm. No specific maximum for oxy as far as I know - it's the addictiveness that's the concern there (assuming you don't do something silly like taking way more than your tolerance allows for).

 

[lazylazyjoe]

He should have told his doc that APAP makes him sick. He could have prescribed oxycodone 10mg with nothing else. I have told this to docs before and it they usually don't mind.
I have known people who have done way too much APAP, and from then on even small amounts agitate their stomaches. So, it's important to stay under that 4g limit. If you have any liver problems (like Hep) and you should observe a lower max.
If you tell you doc that you are in serious pain, he probably won't take them away. You're unlikely to get something stronger though. Doctors are under real scrutiny when it comes to their prescriptions, so often they under prescribe. You're only real options are to suffer thru this, or find an illicit source. Just don't forget that the more you do, the less effective that each dose is, and the harder it will be to stop when the pain is gone.

 

[SPC123]

I actually have trouble with APAP and so get straight Oxy IR. The reccomended daily dose as Shambles said is 4000mg. The max individual dose (or the most the reccomend you take at one time) is 1000mg. So basically, you could take 3 of those pills 4 times a day and be within the reccomended APAP limits. The 4000mg limit is per day, not all at once (although I am not sure it would hurt much more to take the 4000 all at once). I will say this: APAP is a dangerous drug. More people suffer liver failure and die from APAP than from alcohol.

I suggest what Lazy said. Take a few, go back to your doc with the bottle and tell him the APAP makes you sick. Mention that you have a hard time with Tylenol and didn't realize it was the same thing in the drug. Chances are the doc will take the percs and scrip you 10mg Oxy IR. That said, if you already have half the bottle gone, you might be out of luck. Could always try Cold Water Extraction. Just search for it in the search box.

One other thing: If this is really about pain, APAP does help with pain. Most people want straight Oxy because they want to get high without killing their liver or messing with CWE. The APAP may well be helping with the pain, so that should also be a consideration. Short term, going over the reccomended limit probably won't cause any problems provided you aren't already an alchoholic or have some sort of liver disease.

 

[lazylazyjoe]

APAP overdose is extremely painful. One of the most painful ways to die. And even if you survive, your liver is shot. Please don't ignore the max OP. You will regret it.
Otherwise, I've had my gallbladder taken out and many painful infections (some needing hospitalization) in the past year, so I understand the need for pain relief. Just don't let that lead to picking up a habit. The line between the two is very thin. Like I said, the more you do, the less effective each dose is, and the harder it is to stop. I wish someone would have tattooed that one my hand when I first started.

 

[opivet]

High tolerance need good Oxycodone IV dosage

I take 4/ 100mg MS contin and 6/ 30mg Oxycodone a day, what would be a nice nod IV dose of the Oxycodones? I will never never try to IV those MS's or the Opana ER's that I switch back and forth with. That is all, thanks.

 

[whippa craka]

APAP overdose is extremely painful. One of the most painful ways to die. And even if you survive, your liver is shot. Please don't ignore the max OP. You will regret it.

True, but just because your pushing 4g a day or even 10g a day, doesn't mean you will die. I know junkies that have been popping 15g/day of APAP for years. I was blown away they weren't dead, they're skin wasn't yellow or had dying spots all over them. A DEATH from APAP is more common from teenagers who do a whole bottle of APAP in hope they will just fall asleep and die, far from the truth. Regular semi-high dosages, doesn't pose an immediate risk of death, you will see MONTHS of symptoms if your living is starting to fail from constant APAP use.

I take 4/ 100mg MS contin and 6/ 30mg Oxycodone a day, what would be a nice nod IV dose of the Oxycodones? I will never never try to IV those MS's or the Opana ER's that I switch back and forth with. That is all, thanks.

Why not? In all honesty, the opana would be the best to IV. Thats what morphine does, and the best way to take the most advantage of it. I think the oxies would be safer to IV though. What's the most you have taken at once? I would say definitely for your first time, don't do any more then 100mg if your tolerance is truly that high. IV brings alot more to the table then you can expect.

Also, Why the fuck are you starting to IV? Don't do it.

 

[opivet]

.Ya I get a lot of that. I know the rush, had it in the hospital a couple of times when the anesthesiologist got tired of me whining for more so a couple of times he hit me so hard with Fentanyl I actually told him to back off. I guess I just want to feel that same rush once in a while. I have all these damn meds and I get bored with em. Now RE: the 100mg, are u referring to the morphine other oxycodone s? I think what has happened with me is A) I have spent so much time exposed to having needles and IV's in me over the years and again recently I've been having epidurals and the like, which I always demand IV sedation for that it just doesn't seem like a big deal to me. I do indeed have quite the addictive part in me so I can't say there is no risk but I really couldn't get away with being a regular IV user.
So do u have some special double secret method of making the MS's and Opa's safer to IV without needing a PhD Org. Chem.? I've burned out on reading the hundreds of threads on how u can or cannot safely defeat and prep these damn pills. If you do have a way please hare it. I'd be pleased with just being able to insuf them. Thanks for discouraging me from IV'ing at all, I'll let u know how it comes out either way.

How much have I ever taken at once? A lot, probably 1200 of the MS, maybe 300 of the Oxyc's. IDK is that even a lot?

 

[whippa craka]

How much have I ever taken at once? A lot, probably 1200 of the MS, maybe 300 of the Oxyc's. IDK is that even a lot?

Yes, especially if the oxy is instant release. Rarely do I see sustainable 300mg/day oxy habits. Either they're on dope or in jail by then. PLUS the opana... lol.

It is really unsafe to mess with IV'ing MS Contin, I was thinking about an IR form of oxymorphone. Be sure to read up. Crushing up a pill and IV'ing it is alot different then a hostpital administering a solution ment to be intravaneous. Use the correct solution, filters, needles, all that.

 

[NeighborhoodThreat]

Don't IV MS Contin. It's very, very dangerous.

Just so everybody knows, there is a difference between oxycodone and Opana. Oxycodone is oxycodone and Opana is oxymorphone. I think there's some confusion regarding these two.

And yes, 1200mg morphine and 300mg oxycodone is an extremely high dose.

 

[opivet]

Considering my above mentioned tolerance, would two of the Oxycodone 30's be a good safe dosage IV?

 

[effie]

Oral bioavailability of Oxycodone is about 60-90% according to this. Going by the lowest value to be safe, 60mg of oxycodone IV should still be okay for someone with a 300mg oral tolerance. Be careful though.

Have you IV'd pills before? Besides the usual IV risks, it's really not a safe thing to do due to the fillers and binders in the pills. You need to use a micron filter to stop them entering your bloodstream - if you don't you can end up with a dangerous lung condition called pneumoconiosis. See this thread.

I don't really see a lot of point in IVing oxycodone to be honest as the oral bioavailability is pretty high - the risks of IVing pills def seem to outweigh the benefits.. I'd stick to eating them if I were you!

 

[opivet]

You know what Effie, I think your bang on, I'm going to lay this pursuit to rest. Kind of a relief having this sorted. with all the obsessive feelings and behaviors I've been experiencing leading upto my decision to try this. This makes it academic, my MS Contin' are too dangerous and the Oxycodone' not worth it. Ya I mean I've been doing the gen up on the instructions in these forums over and over again, practicing all the steps leading right up to the injection itself. Now the desire and the driven obsession have left me, what a relief. Thank you for helping put the final nail in that coffin. Who knows where or how far I could have taken this with the way I and the amount of meds I'm prescribed every month,could have wound up a baghead. If I really need to get battered I can just plug 4 of my MS's. This may have just saved my life. How's that for a little drama? Sorry for yakking so.

TTFN Effie,

Hans

 

[effie]

That's brilliant, I'm really glad you made that decision! IVing really is a dark and twisted path to embark on - I can understand why people are tempted but it would not have ended in a good place and it's a path I really hate to see anybody take the first step down.

Plugging is a great alternative to IVing, so much safer, high bioavailability and can give you a decent rush too, depending on what you plug.

Really pleased for you

edit - I'm going to close this thread now, partly as it's a resurrection of an old one and partly as your questions have been answered and you've reached your conclusion, but feel free to send me a pm if you have any queries, or start a new thread if you have a new question!