(Moving from Anonymous) You may want to take an antihistamine like Benedryl (diphenhydramine) beforehand and that should help with the itch. Oxycodone itself is not known to be toxic to the liver and itching is a common side effect. You did not specify which formulation you are taking. If your formulation contains acetaminophen, too much can harm the liver. It's not recommended to exceed 4,000 mg acetaminophen in a 24 hour period. However, we are not medical professionals and unable to give diagnoses. If you have health concerns, consult with your physician.