It could be enzyme-related. But it also increases dopamine, among other things.
Surprising it's not a more frequently used combination, that being the case?
Yeah that's why I was asking @JohnBoy2000 if they like cocaine. Cocaine and Ritalin both act as RIs of dopamine and adrenaline, but only cocaine also inhibits serotonin reuptake, kinda completing the trifecta, as it were. So yeah, add that to the dopamine-enhancing effects, and I could see this being the net effect. It makes sense.
Tramadol has a lot of counterindications, and then mixing it with a 10 mg Oxy-IR, well to start, that's probably too much for someone without tolerance, particularly on top of the Tramadol. And then mixing that dose with a half a Xanax bar and zero tolerance, again… too much. This is a bad, potentially very dangerous drug combination. Sure the Ritalin kicks back some, but that's the one thing they have some tolerance to. So please, @JohnBoy2000 don't take these doses. Besides, the opioids are nauseating, constipating, and counterproductive. Not knocking them—they have their time and place—but I don't think it's what you're looking for right now.
Well it's not really medically desirable. Euphoria is an unwanted side effect for any clinician. Leads to compulsive drug problems and malpractice insurance providers really frown on that stuff, to say the least. And meanwhile antidepressants are rarely used recreationally, so it stands to reason…
That's not proof of anything here though. I'm sure you don't read every journal out there cover to cover, so to speak.
If produced via ephedrine/pseudoephedrine, it will all automatically be rearranged as the d-isomer, which adds to those routes attractiveness and elegant simplicity. For serious, both the Nagai and Birch reductions are beautifully simple and wonderfully effective, particularly the Birch. But I digress. If the meth in question is made from P2P or P2NP, then the initial results from reductive amination are racemic. Most modern labs will separate and resolve the isomers with tartaric acid, converting the l-isomer into a new racemic batch to be separated again and combined, repeat, ad infinitum and the purity gradually comes up to an acceptable level near that of ephedrine-derived meth. This is usually around 92%.
If taken orally and in doses mirroring—or close to—that of Adderall, then they're fairly indistinguishable. Anecdotal reports though indicate that meth can be less productive, more scattered, and more given to distractions and impulse. I like to tell people that meth is generally better as a recreational stim like MDMA or Coke than it is a productivity stim like Adderall, Vyvanse, Dexedrine, or Ritalin. I also joke that the Axis powers during WWII were hopped up on meth while the Allies were using benzedrine (bennies, aka amphetamine), and we all know who won the war…(this is somewhat true, look up Pervitin) lol, but of course this maybe had no net effect on the war's outcome, though some people claim Hitler's documented daily injection of methamphetamine didn't help him make good decisions toward the end of the Third Reich. If so, thank God for meth!
That's right. It's mostly only active in the peripheral nervous system. So it speeds up the heart and causes vasoconstriction and bronchial dilation. It just doesn't affect us mood-wise or cognitively very much, not directly anyway. Because it's extra work and expense processing the unwanted L-isomer out of a batch of racemic P2P meth, it's kinda become something of a de facto cut when some of it is left in. Quality suffers but there's less labor and more profit. But it's nasty and it thwarts contiguous crystal growth. Anyone who uses knows that easily crushed, crumbly meth is not high-quality. It should be super tight, rigid, contiguous flat crystals that don't get bigger than a quarter and ❊tink!❊ like coins on a hard surface. Should be clear-ish but also cloudy white and not absolutely clear. Unfortunately quality still varies quite a bit and virtually no one prescribes Desoxyn or Methedrine anymore. Too risky with patients and potential malpractice claims bc too many ppl get carried away when they discover that meth has a rather high capacity for abuse. Those lacking self-discipline need not apply.
Just in relation to this;
journals.lww.com
Yes, good point... I also have a script for Bupropion XR 150 and definitely it makes Ritalin more noticeable and effective
Coming back to this, Vyvanse, do you recall your dose?
Well there are 20, 30, 40, 50, 60, and 70 mg dosages available. Most doctors start adult patients at 30 mg and adjust the dose as needed.
Yes, but it's kind of a moving target given how quickly tolerance sets in as these drugs build up in the nucleus accumbens. In time, it's necessary to allow dopamine downregulation to wear off if one wishes to restore the drug's full potential again.
Yeah that's about right. Owing to the fact that Vyvanse/Lisdexamfetamine is a prodrug for amphetamine, and the body has to metabolize it first, it exhibits something of an extended release functionality. As such, do note that Vyvanse lasts 8 – 12 hrs instead of Ritalin's 3 – 5 hrs.
So 20 mg of Ritalin is equivalent to 50 mg of Vyvanse, roughly, just do note the difference in duration of effects.
| Ritalin (methylphenidate) | Adderall IR (dl-amphetamine*) | Adderall XR (dl-amphetamine*) | Vyvanse (lisdexamfetamine) | Dexedrine (d-amphetamine) | Desoxyn (Methamphetamine) |
|---|---|---|---|---|---|
| 5 mg | 2.5 mg | 5 mg | 20 mg | 5 mg | 1.25 mg |
| 10 mg | 5 mg | 10 mg | 30 mg | 10 mg | 2.5 mg |
| 15 mg | 7.5 mg | 15 mg | 40 mg | 15 mg | 3.75 mg |
| 20 mg | 10 mg | 20 mg | 50 mg | 20 mg | 5 mg |
| 25 mg | 12.5 mg | 25 mg | 60 mg | 25 mg | 6.25 mg |
| 30 mg | 15 mg | 30 mg | 70 mg | 30 mg | 7.5 mg |
one difference 10 mg MPH will kick in, if using first time, as a beast ime.
Don t, if you want some direct SRI action go for Kanna I read. No personal experience.
Methylphenidate does not exhibit serotonergic activity. Probably not an issue. Cocaine is serotonergic though, and so are Adderall, Vyvanse, Dexedrine, Amphetamine, and Methamphetamine – basically all amphetamines to a greater or lesser extent. Psychedelics even more so. But Ritalin differs from cocaine, for example, in this 5-HT activity difference. Otherwise they both act as reuptake inhibitors, cocaine a triple monoamine RI and Ritalin a double.
Yeah apparently the medical community considers Adderall IR to be twice as potent as Ritalin and Adderall XR, which they consider equal in mg. Same for Dexedrine. Meanwhile for Desoxyn, aka meth, they have it down as being a fourth the potency of Dexedrine, and half that of Adderall IR. This makes me realize they're afraid of lawsuits and malpractice insurance rates skyrocketing. I don't think it's being based on Ki values and actual affinities for various neurotransmitter receptor sites. It's arbitrary and an outdated system of trial and error. What is needed is for pharmacogenomics to mature and reach critical mass so we can customize people's prescription to match their personal genetics and enzymology. But that tech is still on the horizon for now.
It was the PNS Nor-Epinefrine they both expose i was afraid. 1+1=3
depends on tolerance and stuff. I have experienced that I need more stimulants after sleeping on mirtazapine to break through and lift off the drowsiness. But maybe there is more synergy once tolerance to antihistamine effects develop.
