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Risks of large 2c-x doses?

30mg 2c-b is about the highest id go unless you were in a perfect set/setting environment :)

ive only done 2c-b and have no exp with other 2c-x so I cannot speak on those -- i soon will try 2c-i :)
 
On high dose 2ce 50mg my heart rate goes off the charts. With 2ce I cant sit still feels like im bout to explode and my mind just keeps shuffling through thoughts repetitivly. As for 2ci I really dont have a problem up to 60mg maybe a little stimulation but nothing serious, my good buddy has did 45mg and 5 hours later did another 45mg and was basically fine, he did say it got quite stimulating but thats expected at 90mg. if I was to combo 2cs I would defintley space them out at low doses and move up slowly, my same friend who did 90mg of ci has done 40mg of 2cb with 40mg of 2ci at once and said not good shoud have defenitley spaced them out with 6 hours inbetween at those doses. I dont really recommend high doses but I figured id share my experience with them

Take it easy everyone keep it safe
 
The one time I accidentally took an over-100mg dose of 2ci I experienced unpleasant vasoconstriction with shivers and muscle contractions. My heart and head were pounding and I became very anxious. At one point I had to sit down on the sidewalk and put my head down for awhile. I didn't have a panic attack, but I really felt on the verge of needing to go to a hospital. This lasted about an hour, after which I started to come down and the physical effects decreased. I had a pounding headache and bizarre lingering visuals for 2 or 3 days (not patterns so much as I would literally see the wrong thing -- a postman looked like a guy in a bear suit; I mistook a stapler for a rat). Ever since then I have had pronounced negative physical effects from 2ci (but not other 2c's) -- it could be psychological but I feel like I burned out on 2ci. I do remember having the most amazing visuals at the time -- the architecture around me was utterly alive as streets were waving around like tentacles and houses shuffled back and forth. Instead of walking I felt like the sidewalk was grabbing my feet and pulling me forward.

I know other people who can take over 100mgs of 2ci without problems, but I'm a lightweight with phenethylamines as 20mg is a strong dose for me. Also, I have taken nearly as high doses of 2cb without as great negative effects.
 
One individual warned that these super high doses can be dangerous for heart rate and such.

It depends as much on how often as on how much. Drugs that bind 5-ht2b -- MDMA, DMT, fenfluramine, some 2Cs, mescaline -- have short-term and long-term effects on the heart. Fenfluramine is the poster child for this, but fenfluramine showed this damage when people took it every day as an appetite suppressant.

In a related story, fenfluramine is roughly similarly neurotoxic as MDMA, and Dr. Nichols has suggested that the long-term effects of fenfluramine, which are minor, may generalize to the long-term effects of MDMA, implying they aren't too serious.

I don't think occasional use of ~50 mg doses of 2Cs is likely to be a problem, but if you're using them often enough to have a tolerance requiring 50 mg for psychedelic effects, that may be a problem. The 2C's are not as well-studied as some other drugs.

Why do people call LSD a tryptamine? It's as much a phenetylamine as it is a tryptamine...

The way LSD binds to the 5-ht2a receptor, it has a conformation resembling that of the tryptamines moreso than the phenethylamines.
 
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While weighing out a gram of 2c-i into several different containers, I ended up taking upwards of 80mg (a low estimation; I was licking my surfaces and gumming etc, and dosing myself as well). Don't really know why I did it, but it happened. It was the third time I'd taken 2c-i, about a year and a half ago. Anyway, at first I was scared and the nausea and body load was intense. I'm absolutely terrified of vomiting, so I spent an anxious hour writhing on my futon before running into the shower. An hour and a half in, the visuals were like nothing I'd ever seen. Typically I get more vibrant colors, and this kaleidoscopic overlay moving over everything, but this time, everything seemed to be vibrating.

Music was unreal.

After 2 hours I became more accustomed to the visuals and the body load kicked in. Literally felt like a micro-orgasm every 20 seconds, accentuated heavily by the music (Debussy) in the background.

I wasn't functional however.

Long story short, I'd say keep 2c-b and 2c-i under 100mg. If you're gonna go for a larger dose, make sure you're prepared, be ready for the nausea. Get some good fucking headphones.
 
theoretically?

extreme psychotic break?
running amok naked in the neighborhood, fighting cops, screaming?
extreme cardiovascular stimulation requiring sedation to the point of respiratory failure and breathing machine?
stay in the psyche ward?
traumatizing family?
losing your home?
possible heart damage, confirmed liver damage?
 
Ive only tried 2 of the 2C's: 2C-B and 2C-E. Ive gone up to 35mg of 2C-B which was just absolutely brain rattling in the best way possible. And the highest I went with 2C-E was 90mg with tolerance (Had taken 35mg the week before. I had ). It was one of the most beautiful trips Ive ever had.
 
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