Ringed Mescaline Analogue/Chemical Masturbation Thread

[dorothyperkins]

Ah, the reason i didn't draw it like that is because the nitrogen is attached to an aromatic ring, reducing it's basicity, it's probably not active. Also it's in the postition occupied by the oxygen in psilocin, so this can't be a good position for receptor binding.

 

[IGNVS]

hmm, what if you had an aminoethyl sticking out of the top right corner of the new ring? it would be basic again.

if indole is the phenethylamine version of this concept then the molecule i described with the aminoethyl would be the next step up of tryptamine.

can you describe why the nitrogen being there wouldnt be good for receptor binding?

 

[Ham-milton]

What is the proper term for the family of compounds shown in the image, ignoring the blue, that is? And has anyone ever looked at compounds including something (anything, that is, I just drew an unsubstituted hexagon for simplicity's sake).

Or for that matter, has anyone looked at red-space cyclohexene-substituted anythings been looked at? Or would that alter the conformation negatively?

Since the DEA seems to only consider analogues of substances to be within the same family (like 5-MeO-aMT an analogue of AMT, but not an analogue of DIPT), is it fairly safe to say that the structures described on this page will be outside of the analogue act? I would think so, but I'm not sure.

How does the potency of these 3-ringed buggers compare to their 2-ringed brethren? Or are they a complete unknown?


sorry for the small image

 

[Ham-milton]

Here's total stoned chemical masturbation... What else is there to do while the wife watches "A Walk To Remember?"

I got the idea for this from the psychedelic imidazolines, but I added a nitrogen where it belonged so it could be a pea-type, but left the 5-sided ring, although it's altered quite a bit. It looks more like pyrovalerone as it is. The nitrogen really needs to be where it is on the (a-methyl)pea's or you're out of much dopaminergicity. look at atomoxetine, the N is a step further down and it's all NE. Or maybe I'm just high and making conclusions that don't make any sense.

I really doubt it'd have any activity, but if it did, perhaps the imidazolines-as-psychedelics aren't as disparate a species as they first appeared.

edit: I'm thinking of MDL101,156 (I think it's just called M101,156 now, though, shown here:

so basically all I did was move the nitrogen one step closer, and then alter the ring accordingly (well, the way I felt like... since I'd been looking at MDPV today, could have done it differently, I suppose).

 

[IGNVS]

...................___......N..
..................|......\__/....
..........\.......|___/.........
...........\..__/......\.........
............O....\___/.........
.............__./.......\.........
......F__/..............O.......
........../.\..............|........
.........F...F.............|........

...............................N..
..................Br.....__/....
..........\.......|___/.........
...........\..__/......\_Br....
............O....\___/.........
.............__./.......\.........
......F__/..............O.......
........../.\..............|........
.........F...F.............|........

anyone?

 

[Hammilton]

Bottom one seems dangerous for some reason, and the top one, I think, will be of lowered potency.

 

[IGNVS]

support your claims sir

 

[dread]

You know, I'm going to post all the results of my playing with chemsketch by the nights.

 

[dread]

One didn't fit..

edit. added one more, in 3d.