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Opioids Reversing opiate effects

F

Fuzzybal

Greenlighter
Joined
Jul 24, 2011
Messages
5
Hello, i have dabbled with different types of opiates for some time now, and sometimes has over indulged. Sometimes i wish the effects would stop due to important tasks, and was wondering if there are any methods or something to take to reverse the effects of opioids on the body. Does anybody know anything?
 
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Don't take them in the first place, I mean like if you need to do Important task, I only get high at night because of this reason.:)
 
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Welcome to BL. We don't use swim.


You could take an antagonist like naloxone, but it's not recommended if you're physically dependent as it may start withdrawal.
 
If you have taken enough to get to the point of overdosing, taking an antagonist like naloxone or naltrexone (narcan) will bring you out of OD status. But doing this on your own without professional medical help will be dangerous. The answer is to simply NOT over-indulge. If you have taken opiates before you should know where you tolerance is at, so don't take too much..

It is best to start your dosages low, and titrate up until you are at the point where you want to be. You can always take more, but once you take it you cannot undo it.

Also, please edit your post as we do not use SWIM here. We all know it is you, and it does not protect you from any legal ramifications if that situation where to potentially arise.
 
This might sound a bit snarky, and I don't mean for it to, but you should probably stop taking your opiates at times when you could be asked to take on an important task.

Also, and I'm not entirely sure how well this might work, but a stimulant like dexedrine or even a large dose of caffeine may help to counteract an opiate's effects.
 
If you can get ahold of naltrexone, research low dose naltrexone (should be called extremely low dose naltrexone with reference to opiates). It is usually performed about an hour before dosing to potentiate effects, but it could temporarily block the effects of opiates if you're already on them. It could be a fine line between feeling normal and feeling slight/moderate withrawal symptoms, though. There's a great youtube video if you search 'low dose naltrexone' - a basic video with a narrator and visual representations. It explains the effects on the opioid receptors and the rebound effect, etc.
 
Caffeine? IME it did work a bit to make me more alert when I was too noddy for the occasion.
 
I dont know about caffeine, but I actually find that speedballing, or shooting coke or speed (or popping) while on heroin, actually intensifies the heroin more. The only case where this wasn't so was when I took MDPV on top of opana, and that was like I never took opana at all.

so yeah, smoke some MDPV, that will get you out of your haze.
 
In my view it would be seriously dangerous for you to dabble with antagonists like naltrexone. These things are dangerous/intensely uncomfortable at the best of times, and even if you get the dose perfect you will probably just spew immediately and feel even more incapacitated than you did on the opiate.

If you can't just abstain, then things like caffeine/energy drinks/showers/exercise would probably be best.

As someone else said, trying to 'reverse' a downer with an upper never really works, but just gets you more uniquely munted.
 
As a friend of mine once said: "Taking one of these (*holds hand up*) to counteract one of these (*holds hand down*) never puts you here (*holds hand level*) but puts you here (*holds hand to the side and behind head*)".
 
Thanks for everyone's honest opinions, Of course not taking them Is the smartest decision, but we all fuck up at times. I did have a energy drink, and some methylphenidate did the trick quite nicely
 
Will taking a suboxone (either sublingually where the naloxone is inactive, or IV where the naloxone is completely active) bring one out of an opiate overdose? There seems to be alot of controversy surrounding whether or not you can use suboxone to bring yourself out of an overdose. Some believe that if you were overdosing and having trouble breathing or whatever, and IV'ed a suboxone, that it would bring you into precipitated withdrawal and thus out of an overdose. Although shooting suboxone is undoubtedly horrible for you, its certainly healthier than OD'ing on heroin. What do you guys think?
 
^I have read anecdotal reports of people successfully bringing people out of OD's by administering a shot of suboxone in the ODing individual. I wouldn't take this for 100 percent fact, though. If you are with someone who is overdosing the best thing to do is IMMEDIATELY call 911 and get professional help. Administering antagonists, especially when someone's life on the line is best done by medical professionals. Also, the naloxone in suboxone is virtually inactive regardless of ROA. The binding affinity for buprenorphine is greater than that of naloxone in all ROAs and will be rendered virtually ineffective. The bupe is responsible for precipitated withdrawals, not the naloxone. The naloxone is added as a deterrent but it is a common misconception in regards to its effectiveness.
 
As has been said, you can reverse the effect with naloxone or naltrexone. Don't count on it being pleasant though.

Mixed agonist/antagonist opiates like bupernorphine *could* reduce the effect, if you where 'higher' then the mixed agonist/antagonist can get you.

Psychomotor stimulants will decrease or reverse some effects... sleepiness, fatigue, repository depression, hypotension/brachycardia, motor weakness and in the norepinephrine releasers, itchiness. Of course, throwing in a blast of meth or a rail of coke is probably a highly suboptimal solution to your problem. (and may increase the risk of serotonin toxidrome with synthetic opioids... The pro-emetic effect also would be no fun) A few cups of coffee might take a bit of the drowsiness away safely though. (caffeine is used in for example tylenol 1,2,3 for that purpose)

Best idea is to curtail you use, or at least curtail it when you know you need to do things.

edit: To above poster. I've personally encountered scenes where someone has successfully administered naloxone to someone with an opiate OD while awaiting emergency response. I've never seen or heard of anyone, profession or not, using bupe successfully as a treatment for acute overdose, don't try this at home, and call for EMS, Police or Fire in all cases of acute overdose.
 
^I wasn't saying naloxone is ineffective in itself. But in combination with buprenorphine (such as suboxone), the bupe always out competes the naloxone at the receptors. It is a common misconception that the naloxone is responsible for precipitated withdrawals with suboxone, when it is infact the bupe that causes this. Which is exactly why both suboxone and subutex both cause precipitated withdrawals in the exact same manner. Because of the bupe, not naloxone.

Now if you were to administer naloxone on its own, it would be a different story entirely.
 
suessmayr said:
In my view it would be seriously dangerous for you to dabble with antagonists like naltrexone. These things are dangerous/intensely uncomfortable at the best of times, and even if you get the dose perfect you will probably just spew immediately and feel even more incapacitated than you did on the opiate.
Click to expand...

It can be very dangerous to dabble with opiates and naltrexone in the same day. I have done things like take a dose of opiates in the morning, do a mL (~0.05 mg) of my naltrexone mixture 5 hours later, and take more opiates an hour after that, with good results - after doing the low-dose nalt - 30 seconds of feeling like I'm about to start withrawal, followed by a slight surge of euphoria lasting 15 minutes, followed by feeling sober until I dosed again, and feeling like I took more opiates than I actually did (yes this could be placebo but I doubt the chances). You have to really be careful whn you mix it or results could be bad. I would advise against bupe for the OP's purposes. Naltexone is a very different drug and acts on opioid growth factor.

Low-dose naltrexone has shown to have good effects on the body (increased endorphins), and I don't think it should be demonized here on Bluelight...that job is for the money-hungry pharmaceutical companies. As far as trying low-dose naltrexone while you are still high on an opiate, this I do not know about.

About the caffeine thing - caffeine is a well-known opiate potentiator, no question.
 
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I'm skeptical about low dose naltrexone as a means of potentiating opioids or rather what it's supposed to do, i.e. feeling normal and not feeling urge to take heroin or some other opioid agonist. I don't really believe naltrexone begins acting as a partial agonist on MOR after some time of use. It's no secret the body needs to get used to a new situation when an agonist is stopped. When you deliver something acting on opioid system from the outside, it's normal the body doesn't "feel" the need to produce endorphins, enkephalins, or dynorphins and it doesn't start to produce enough of them after discontinuation of the habit right away.

Anyway, isn't naltrexone therapy expensive? Be it in rapid detox or as a blocker after detox (at least it is in Poland but it's caused by the fact naltrexone isn't synthesized by any Polish pharmaceutical company and it doesn't figure on the National Health Fund list, you can't buy it at the drugstore, one must import it from abroad).

During the first months of my morphine use, I overdosed. Ephedrine i.m'ed brought me back to life, I know it's far from normal action one would take up in such a circumstance. Later there were a few naloxone ampules just in case. But wouldn't any of you try to give a low dose of some stimulant like amphetamine to a dying person on the street if it was at hand? I'm against using depressants and stimulants together. I might have been totally numbed after combos like an opioid + meth/methcathinone or heroin + cocaine but I felt how it was overwhelming for my body.

Caffeine might potentiate opioids because of a way it's metabolized but then you've got both higher than normal levels of an opioid and caffeine, and so it "disrupts" opioid experience. It's actually a good idea to give someone overdosing strong coffee before you get that person to the hospital (something similar I experienced during my second and last overdose on morphine, I was slapped in the face to be conscious enough to swallow, then I was taken to my then girlfriend's apartment to get a naloxone shot).
 
My main objective by starting this thread was to find readily available methods of either reversing, or "flushing" the effects out of my body for the time being. However, it is good to know methods in a broader aspect aswell, great posts guys
 
adder said:
I'm skeptical about low dose naltrexone as a means of potentiating opioids or rather what it's supposed to do, i.e. feeling normal and not feeling urge to take heroin or some other opioid agonist. I don't really believe naltrexone begins acting as a partial agonist on MOR after some time of use. It's no secret the body needs to get used to a new situation when an agonist is stopped. When you deliver something acting on opioid system from the outside, it's normal the body doesn't "feel" the need to produce endorphins, enkephalins, or dynorphins and it doesn't start to produce enough of them after discontinuation of the habit right away.

Anyway, isn't naltrexone therapy expensive? Be it in rapid detox or as a blocker after detox (at least it is in Poland but it's caused by the fact naltrexone isn't synthesized by any Polish pharmaceutical company and it doesn't figure on the National Health Fund list, you can't buy it at the drugstore, one must import it from abroad).
Click to expand...

What I'm referring to is low-dose naltrexone. Its being used underground to battle auto-immune diseases because of its action on the body (though people doing this are taking around 5 mgs as opposed to .05mg for opiate potentiation). Watch this video - http://www.youtube.com/watch?v=xr-n8jMLenU

And naltrexone is very cheap, at least in the USA. This is why pharmaceutical companies are reluctant to start real studies on it, both for autoimmune diseases and opiate potentiation (as in a pill that releases a micro-dose of naltrexone immediately and a smaller-than-usual time-released dose of oxy).
 
It's very possible the use of an opioid antagonist for some longer period of time (but lasting longer than naloxone which is excreted very fast) will then make opioid agonists produce more pronounced effects. When opioid receptors are blocked by antagonists with higher affinity than agonists commonly used to get high off, not only drugs like morphine cannot bind to opioid receptors but also endogenous opioids. And just like with any other neurotransmitter it's crucial that endogenous opioids levels are at certain level so the body behaves in a certain normal manner in various situations. So taking opioid antagonists stops normal opioid signaling just like supplementing the body with agonists like morphine, the difference of course are effects.

Naltrexone is effective in rapid detox and in blocking agonists action after detox. That's what we know for sure. I don't know if the thing is naltrexone is cheap or it's something else (well, I didn't refer to the synthesis because that's piece of cake for a chemist who knows how to synthesize oxymorphone and N-demethylate it, putting the appropriate group on nitrogen then is a formality). It might be some scientists actually encourage physicians to use naltrexone off-label (and there's more and more diseases naltrexone suddenly turned out to be a miracle drug for).

I'm definitely fond of researches on various opioids as they might be much more than analgesics. Sometimes I wonder if it's the stigmatization of this class of drugs that makes it "impossible" to bring any opioid on the market to treat some totally different problems like depression or anxiety. Concerning low-dose naltrexone, I've seen it used as a means of blocking the psychological urge to take the opioid agonist one was addicted to because it somehow starts to act as a weak agonist after some time of use. How is it possible the drug changes its pharmacodynamics depending on how long it's used? People do get different effects from a single drug depending on the time they take it, e.g. SSRIs that can lift up the mood at the beginning and then start being like a trigger for mania because of prolonged blockade of the serotonin reuptake but it's a different thing, pharmacodynamics doesn't change here, it's just the fact there's too much serotonin after all.

Now I see from the video there's another probable off-label use of naltrexone. It's good for a lot of things and all claims are apparently backed up by scientific researches. But we know what world we live in. Everything can be manipulated so eventually you can't be sure of anything that touches the topic that create opposite opinions in different people. And opioids have been that kind of topic since their use as drugs altering mood.
 
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