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Gabapentinoids Retro Sedatives  Megathread

red22 said:
"my muscles were so relaxed that they literally felt like they were melting" [Quaaludes]

indicocybin420  2026-08-12  h‍ttps://www.instagram.com/wallachlab/p/Db6xg9ZgbAf
Click to expand...

Is Methaqualone purely a PAM?

Bacause the dose-range ia far more like older drugs that directly acted on chloride ion gating (certainly the picrotoxin site was identified in the action of barbiturates and chlormethiazole). With both classes you note the dose range is significantly higher than compounds known to purely act via PAM.

I'm not saying you are wrong, only saying that the last paper I read about 15 or 15 sites were listed with methaqualone being everything from a superagonist to an antagonist which again does not fit with the simple statement that methaqualone is a PAM.
 
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