• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio

Research alcohols list

Sorry guys but first off who showed you this list it is ABSOLUTELY ridiculous.

1. Some of those have vinyl chlorides (alkenes connected to chlorine atom) highly reactive carcinogens highly toxic. These will alkylate the shot out of your dna
2. Free aliphatic alkynes??????exceptionally dangerous avoid this
3. TOO MUCH CYCLOHEXANE. one CYCLOHEXANE ring attached to an aliphatic alcohol tail is too nonpolar and will stay in the liver and membranes for bit
The logp is too high for a single aliphatic ring in which nih shift and metabolism cannot occur(not aromatic benzene nucleus)

I highly recommend you delete this thread before some idiot tries any of the above examples sans the aliphatic alcohols without the above mentioned toxic moieties

Zedsdead
 
I think anyone who has access to these compounds (and the money to purchase them, or sufficient reagents and equipment to make them) but lacks the brains to figure out that a compound with high m.w. and only 1 heteroatom is going to have a billion year half life in vivo deserves what's coming to them. We all remember the fun times we had with desoxypipradrol being sold as "A3A Methano" by our good buddy Eric in China. I hear he's still around, and still selling anything that passes as a white powder to gullible people everywhere.

I also know that nobody is out there actively abusing chlorobutanol or the like. Not only are they toxic to the liver and other cells by means of phosgene formation in vivo (like most chloroform/heavily chlorinated hydrocarbons derivatives are), the unreasonable pharmacological properties of drugs like it (multiple hour onsets, many day half life) make "sandbag-over-the-head drugs" like phenobarbital and nutmeg look outright pleasant in comparison.

This is why chlorobutanol is only used as a preservative, and not a sedative, to my knowledge... something like lorazepam is a thousand years in the future when it comes to providing sedation! Even chloral hydrate seems superior, and that's saying something.

saFi3u9.png


This compound in particular made me chuckle. It looks like a monomer for some fancy plastic! I certainly wouldn't be eating it.

The long and short of this is: don't bother with any of these.
 
Last edited:
I can imagine now a poorly speaking China man chemist finding this page and thinking "wow we have most of these plasticizers already!"... Incoming Vinyl halide alcohols... the newest and the deadliest designer drug.. Already in stores near you just burn some plastic...

I just want to know where you found this list because it's pretty obvious you didn't make it nor compile it is
Zedsdead
 
Vinyl chloride used to be a propellant in hair spray before people figured out that it's a carcinogenic alkylating agent... you'd be surprised :P
 
It's frightening a thread must be made on common carcinogenic and mutagenic nature's of molecules.

God dam simple principles need to be explained, I.e nitrogen nucleophilicity in DNA and how electronegative nature of simple atoms like halogens and alkenes allow for easy attack ala DNA. I wonder if even Chinese chemists know these principles.
Danger in ignorance

Zedsdead
 
From reports, apart from minty burps ethynylcyclohexanol sounds like it is very pleasurable. I'd give it a go once or twice myself although avoid regular use. The halogenated version I wouldn't fuck with eric's mom's dick.

Even chlormethiazole looks iffy, structurally speaking with its terminal alkyl halide. But its been around for donkeys years without people dropping like tumor-riddled flies. Doesn't feel (not that thats an indication of carcinogenic effects in the slightest) like its rough on the body, but a lovely, euphoric, clean and very, very effective sedative/hypnotic.

I just took some actually, with a couple of muscle relaxers (tizanidine 8mg), and 80mg of IV morphine. Currently wide awake but I will end up sleepy and ready to get some sleep as soon as the chlormethiazole capsules release their contents and it takes effect. My favourite GABAergic downer of the entire collection of allosteric ligands, at least that I've tried, wonderful stuff. I'm really quite surprised given its efficacy and barb-esque character, at just how little, if ANY tolerance to it I have built up in the several years on the stuff daily.
 
Seems pretty dangerous to be mixing clomethiazole with morphine and others, but what do I know?

Ever had any barbiturates, Limpet? I wonder how clomethiazole shapes up against stuff like Seconal.
 
Alcohol has a rather low therapeutic index. It's one thing to prepare analogs of ketamine or 2C-B, where people have taken even 100 times a normal dose and lived to tell of it. But alcohol will kill you at 10-20 times a normal dose (if a normal dose is two beers), and the possibility that one of these compounds might have an even lower therapeutic index makes taking them particularly stupid.

Why not just use diethyl ether? It checks off every box mentioned in this thread, has a long history of medical use, and isn't metabolized to phosgene.
 
I'd agree in general, about the morph. Although I've been on one kind of pain meds (or more) for 10yr+ now, and am, in a word, stuck with them (although a longterm morph/oxy script isn't something I'll turn down of course). Tolerance is a bitch.

I've had some of the longer acting barbs, barbital and phenobarb, The latter blows, but I loved the barbital. Actually I loved it too much and it came within a hairs width of doing me in. I don't exaggerate when I say that, it very nearly did. And the withdrawals are MOST unpleasant. *shudders*

I'd say chlormethiazole is at least even with barbital, quite likely better. Although there are limits imposed by potential OD of course, but that goes also for barbs, not sure which is the more toxic out of the two. And in large quantities over several days, its possible for some kind of nasty sulfurous metabolite to accumulate, and then be excreted slowly in body fluids, turning the victim into a literal, and extremely potent walking stink bomb. This happened to me once, which is how I know about the effect, and it was sufficient to drive people away from the other side of a road, and permanently ruin clothing, which had to be bagged and binned outside.

Still, fucking love the stuff. Not least because I have accrued no physical dependence on it despite twice-daily dosing (at 192mg BD, occasional rec. use), I haven't taken any in maybe 3-4 days, and have experienced no withdrawal symptoms whatsoever. If I were taking instead, a benzo, for the length of time I've been on the chlormethiazole then no way would I be able to just stop use (ran out) cold-turkey without issue. And it makes even small amounts of alcohol hit like a sledgehammer.

(for others: do NOT drink on this, I titrated up very slowly with both substances until I realized what would be effective without just killing me)
 
Ether is good stuff:)

Done a fair bit in my time, but it CANNOT be used socially really, at least in the presence and/or locality of non-drug-using people. It STINKS. I love the smell of ether. If using the inhalational route then plenty WILL evaporate, and it can be smelled from quite some distance away.

If drinking it, then be ready for ether-flavoured and ether-scented burps all day long. It has a tendency to repeat on you, although it does make rather good cocktails with the right spirits and flavours/mixers. My favourite is a mixture of cheap fizzy limeade, tesco own brand cheap shite, vodka and the sugar-free type of codeine linctus available in the UK, which quite surprisingly, uses chloroform as a preservative. The taste/odor of the latter for some reason complements the limeade/vodka/ether mixture rather well.

Made those with either diethyl or on occasion, diisopropyl ether, and it packs quite a punch. More potent, and far less (if you get one at all) hangover than the equivalent amount of alcohol alone. Never had a hangover from oral ether without alcohol though, although it does sting a bit on the way down if doing shots.


As for the combination of other things with chlormethiazole, unfortunately, I have problems with my knee, hip, over-tightened tendons supplying the calf muscle on the affected side and nerve damage that needs treatment with the muscle relaxant, gabapentin, morphine/oxy combination and steroid shots in addition to NSAIDs applied to the area in the form of diclofenac spray.

Causes me an unbearable amount of pain otherwise, I'm supposed to be having physio, but there is no sign of any reply from them after my doc told the physio folk it was required. Reminded me actually, I need to chase that up.
 
Last edited:
Yeah I love the smell of ether as well, I tried using it once but I had a whole pint or so bottle evaporate on me (while I tried inhaling from drenched pieces of cloth), without appreciable effects. I'm not sure if I would particularly like storing an amount of ether around my domicile for safety reasons and either you need quite some of it or I was doing something completely wrong. That was around the beginning of my drug experimentation by the way. So wasn't paying the attention I would now.
Are other dialkyl ethers a (good) idea?? Anyone have info on their psychoactivity and different pharmacology? Seems like they probably experimented with that centuries ago, in the days of yore.

By the way, amyl nitrates fucking suck, tried once. Probably not in the same league as things mentioned in this thread anyway, but as long as we are getting semi sidetracked on inhalants.

I was confusing / vaguely misrecognizing that ethynylcyclohexane with the alcohol version of it (1-ECX iirc - 1-ethynyl-1-cyclohexanol - or as I thought it should be 1-ethynylcyclohexan-1-ol?), the latter sounds like the second most tried 'research alcohol' after 2M2B. Do we really have to call that 2M2B-OH? Ugh. I kind of like that one by the way.
Had not really thought about it, but are you saying the hydroxy is a bit more polar so at least the body can excrete it? Isn't it still a very lingering one? And the body cannot metabolize the hydroxy I think, thought that was the whole point. So what I'm saying is: are your toxicity concerns not also true for the 1-ECX alcohol? I think FnB tried that, but of course nobody is perfect and it could still be quite toxic.

By the way, is tert-butanol psychoactive? Why / why not? Seems disgusting in consistency if not taste/ smell but am curious anyway.

Good to know about the chlorobutanol, I doubt it is getting abused all that much but on the other hand it is so insanely easy to make. So from what I hear: please don't!!
 
It's really not, you lose all muscular coordination before you get to a toxic level. And it's not like you're wiring the bottle to your face.

Remember, people developed ether inhalation masks that were to be kept saturated with ether and placed on a pt's mouth and nose.
 
Huffing ether seems dodgy. I rather stick to occasional use of 2m2bOH(2-methyl-2-butanol). Ether can be smelled from miles away and the pigs(cops) would say "[sniff, sniff.] Ether! You're going to jail!". 2-methyl-2-butanol is so easy to conceal. I would sometimes act silly and do silly things though. However, my breath would not stink on a small amount of vodka and 2m2bOH mixed in juice or soda and I would seem clean smelling. Meanwhile the people on booze would be tipsier and do much more stupid things, be more irrational and not remember what they did well. I mostly kept the memories of what I do on 2m2bOH. It's sort of cleaner and more focused, but I would like something even better. I'm curious about somehow getting and trying GHB or GBL one day. GBL metabolises into GHB and GHB turns completely into carbon dioxide and water and leaves no traces after a day or so. It would be good to take GHB and the dopamine would be retained more, with the subsequent release of dopamine the day after, this would probably go well stacked with DMAA and then it would be energetic. Like the perfect way to party a day before school/work/gym and then the school/work/gym would be great too.
 
Yeah it does carry quite a way. I remember in my later teen days going on a bender all night with the stuff, and one of my friends at the time commenting on coming to call round at my place that they could smell it down the street..oops.

And there is the issue of flammability and peroxidation, so it should be carefully stored, although I'd have had quite a selection of other solvents on hand anyway (for experimental stuff, not for huffing/drinking=D)

But accidents can and if not carefully stored, in the case of ether, occasionally do happen. Heard more than a few dire tales involving crusty old bottles of peroxidized ether in lab fridges. Its best bought/made as and when its intended for uses relatively close to point of acquisition/manufacture and if not contrary to the user's needs, stored with an inhibitor to retard formation of, or increase decomposition of peroxides (these are generally very shock and friction-sensitive explosives, turning such iffy-looking crusty bottles of things like ether, THF and diisopropyl ether into bombs waiting to happen. I've read of one case of a lab's fridge being blown up into the roof and completely destroyed due to that happening)
 
Last edited:
Going back to the original topic; I did compile this list. It was just an info dump type of list. I didn't heavily research each of those molecules. I understand that many could be carcinogenic. I've condensed it down to four molecules that I think are worth experimentation. Variations of those four could also be considered.

They are (these are all subcutaneous):
3-methyl-3-pentanol - LD50 1100 mg/kg
3-ethyl-3-pentanol - LD50 700 mg/kg
3-methyl-3-hexanol - LD50 680 mg/kg
3-cyclopropyl-3-pentanol - unknown, but probably the best

By the way 2m2b is 2100 mg/kg.

So 3-methyl-3-hexanol (or ethyl) is probably the best available. The cyclopropyl is probably the best of all, but it has never been synthed. The reason for the cyclopropyl is to try to mimic the triple bond that makes things like ethchlorvynol and methylpentynol more potent without causing P450 liver enzyme problems. 3-methyl-3-hexanol is also the backbone of ethchlorvynol with no halogens, no triple bond, no vinyl so it should be safer.

From my research, I've found that you don't ever want:
1 - halogens on small molecules
2 - triple bonds on small molecules
3 - carbon chains longer than five (reduces potency)

But remember, ethchlorvynol has both one and two and was approved by the FDA (if that means anything :) and abused for many years without problems (other than it lasting too long) so I think it's not as bad as you may think. Just to be safe though, I decided to discard any molecules with those features. If you'd like I'll (or you) could remove the list and I'll replace it with the four I mentioned just in case some idiot does decide to try a potentially carcinogenic chemical.

I'm not just some alcoholic or junky. I'm really serious about finding the most potent and least toxic alcohol and I've been researching these in old medical journals. This is not just something I'm pulling out of my ass. The reason I'm so interested in this is because I have severe social anxiety and alcohol is the only thing that helps. What I don't understand is why there isn't more of this type of research going on. The only good alcohol alternative at this point is GHB and it's illegal. With alcohol being one of the most commonly used and most toxic drugs, I'm really surprised that no one is interested in (doing) this research. The only other person I'm aware of is David Nut (I think), and his idea of a z-drug replacing alcohol is idiotic. Z-drugs are nothing like alcohols.
 
How about isopropanol? I've heard of skid row types doing "research" by drinking isopropanol antifreeze, effects are said to be similar to ethanol at considerably lower doses.
 
You must log in or register to reply here.
Top