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Research alcohols list

Synaps3

Synaps3

Bluelighter
Joined
Sep 14, 2011
Messages
260
So for a while I've been researching the most potent, least toxic alcohols for a potential replacement for ethanol or use in "booze pills". I'm very interested in finding the most potent alcohol with similar effects to ethanol. We already know about 2-methyl-2-butanol, but there are countless others, so I've developed a list with the molecules that I think are best. I've done a lot of old medical research in journals, wikipedia, etc. I'm currently writing a large document which will contain all the information on these alcohols LD50, etc. But for now I've just created a list and I would like input from those who are vary familiar with how GABA/pharmacology works to help me decide which one is likely most potent and least toxic and also let me know if there is anything I missed. I know many won't feel this is worthwhile, but I find it very interesting.

Here is a link to my list:
ezikrc.jpg


And I should have a PDF with data in a bit if anyone is interested.
 
And yeah, I know the ones with the triple bond are not good, but I put those in just in case. I also forgot neopentyl glycol - that's another one lol :)
 
As I'm sure you're aware (hehe), alcohol has additional activity on nmda receptors, serotonin, and anandamides that those compounds don't have. I don't see the point of this unless one is a raging alcoholic though.
 
I've only tried 2M2B but I have to say for me it is quite unusual to be truly drunk but I can find it extraordinarily pleasant.I also find it requires effort (I do like drinking but it requires a lot of booze to be seriously drunk) and ethanol can feel pretty dirty. With 2M2B it was very easy to access that serious drunkenness state, and IIRC the hangover was reasonable by comparison though not exactly zero.
The downside is that dosing is tricky and there are issues with being in that black hole territory.

My point is that I disagree with potent alcohols having zero use, or rather than disagreeing... I do see somewhat of a point to it.
Though it's not the development of the decade for me or anything.
 
The intermediate between vitamin B1 & clomethiazole has 10% the activity of clomethiazole itself. You can not post about synthesis on bluelight, even if I missed it for a long time. Wash with more water and voila.
 
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That would be sulfurol?
Apparently an aroma compound for "nutty, beefy, brothy, bready, milky" flavor... not sure if that is nice to ingest pure. :D

VVV yes one of the several names for that is sulfurol. VVV
 
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2-(4-methylthiazol-5-yl)ethanol... no, I've never tried it but in a lot of papers on clomethiazole, this intermediate was also tested....
 
I've been studying these myself for a while. Even ordered some 2M2B but at that point did not dare to consume any. A friend drank it all and said it was ok though.

Synaps could you please send me all the information you have gathered as soon as you get them organized?

Intermediate of chlomethiazole sounds really interesting too. Clubcard, if you can provide links or PM some more info, I'd be really greatful.

Chloral, barbs, benzos etc. would be enough if one could get them easily and cheaply. You would not believe how hard benzos are to get prescriped here and how much they cost at the street. I mean people pay happily 35-fold prices (compared bought from the pharm). I hope this does not violate pricing discussion.
 
I've seen the carbamate but fortunately I read that apparently it is toxic or probably toxic...

I will try clomethiazole soon I think.
 
Clomethizole stink !!! my room smell sulfur even if the chemical is in 2 different bag inside a box. Its also oily. Ill give you a report on the effects soon.

Dose: 400mg, oral
T+1 - No noticable effect

Also, don't snort the stuff is hurt bad
 
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Ewww, to had to the stinky odour, Clomethiazole made my alluminum scale bucket rust in 1 night...

@dooble, you should clear your inbox.

1600mg without most effect , tho, I might have GABA problem so be safe with chemcical.
 
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With life being kinda crappy, it's good to kick back with an accessible alcohol near the end of the week. I find 2m2bOH to be pretty good(better than ethanol), though it didn't reach my full expectations. I guess MDxx(ecstasy) is the only substitute decent enough, but it's near impossible to obtain it.
 
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Ewww, to had to the stinky odour, Clomethiazole made my alluminum scale bucket rust in 1 night...

@dooble, you should clear your inbox.

1600mg without most effect , tho, I might have GABA problem so be safe with chemcical.
Click to expand...

Wtf, be careful please. Clomethiazole can be dangerous like barbiturates. If you have to go up that high in dosage and get nothing IMO you should probably just leave it. Maybe it is not really clomethiazole, or it is and there is another reason like tolerance. Don't screw around with it...

I am going to work my way up to about 300 mg, not much higher, and I will not combine it with anything.
 
It would be hard to fake chlormethiazole, the smell is VERY distinctive, like metallic rotten apple scent, with hints of ethyl ether.
It melts plastic, its a bastard and a half to form salts with and its volatile as the base.

Tastes funky too, and releases histamine to a degree, some people find it does so to an unpleasant degree, although all I've noticed is a stinging in the bridge of my nose, and that I do not get anymore.

But as for subjective quality, best GABAergic I've ever tried, I get the stuff on script and it does a brilliant job of putting me out and/or potentiating a morphine/oxy nod (don't do that, it isn't exactly safe, although I'm tolerant enough to the opioids and done carefully, it kicks arse:P)

I've noticed also, that even when taken daily, (at the scripted dose, 192mg BD, morning and night), despite having taken it for over a 2 years, no signs of physical dependency have arisen whatsoever, I can cease taking it cold turkey, without the slightest ill effect, which IMO is very unusual at any dose for this class of drug.

Be aware though, that it IS similar in its actions in vivo to the barbs, and will kill in overdose, unlike the benzos.

And if you binge on it, there is a built in aversive mechanism, assuming its a nonfatal overdose. Only ever happened to me once, but I started excreting some kind of utterly vile sulfurous probably mercaptan-ish nasty stench-bearing compound in urine, sweat, saliva, nasal mucus (just what one wants, thiols being produced UP the nose haha), potent enough to make people cross the street to avoid it, consign coat, shirt, kecks, belt, the lot, to the bin for good and make me go through several BOTTLES of shower gel to try and banish the stink. That effect lasted for 3-4 days or so.

The thiazoleethanol intermediate at -10x the potency might well be prone to doing such nasty things. And I bet it reeks too. Never prepared it, but I'll give the intermediate a (somewhat hesitant) try when I get round to the chlormethiazole synth I have planned.

300mg is unlikely to do much other than put you to sleep. The capsule forms (freebase in oil suspension) used in the UK are 192mg a piece, and taking 1.5x that isn't IMO a huge dose.
 
Seeing that Alcohol is one of the drugs with the longest history of abuse and that its known to be very toxic in many respects, I think searching for a version of it that is less damaging to the body is a pretty damn good idea. You could potentially save the livers of many people and/or make a shitload of money considering how much money people spend on alcoholic beverages. It is one of the biggest international trade industries in the world i'm pretty sure.

also HELP!? says 1-ethnyl is awesome, assuming they're the same thing.
 
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