relative doses of mdma and serotonin depletion

[sapphire life]

Say you have now built up a tolerance to ecstasy and are slowly bringing down your dosage.. , 4 months ago, i rolled off 7 pokeballs, 2 months ago i rolled off 5 pokeballs, and dec 4, i rolled off 3 pokeballs...i have unexpectedly regained the magic when i rolled of 3..anyways, if i were to take just one on a whim, would it have the same serotonin depletion as say 7 would? is there only a certain amount of serotonin released, and it only feels like the roll is better on 5 because of the intensity with which it is released?

 

[cryptix420]

Dude, no.

When you take 7 as opposed to 1, not only are you completely depleting all the serotonin in your brain, you're also causing massive damage because when the 5-ht runs out, dopamine gets taken up into those receptors (prolly at around 3-4 pokes really) and causes a highly toxic reaction. Dopamine regenerates much more quickly than serotonin, so the more you just keep dropping the more you're fuckin' shit up in that noggin' of yours.

 

[mesial]

Dude, no.

When you take 7 as opposed to 1, not only are you completely depleting all the serotonin in your brain, you're also causing massive damage because when the 5-ht runs out, dopamine gets taken up into those receptors (prolly at around 3-4 pokes really) and causes a highly toxic reaction. Dopamine regenerates much more quickly than serotonin, so the more you just keep dropping the more you're fuckin' shit up in that noggin' of yours.

I'm pretty sure I read on thedea.org that the theory of dopamine uptake into serotonergic neurons was not as well supported as once thought. I believe the massive amounts of oxidative stress on axons is more widely accepted as the main cause of neurotoxicity with MDMA abuse. If you abuse the drug it will damage your brain, this is much more of a concern than simply losing the magic. Be smart, be healthy... Take a reasonable amount of Mdma spaced out by at least one month and take your antioxidants.

 

[sapphire life]

Nah, I understand all of this, and which is why I have lowered my intake..and I am over doing so much, less is more with MDMA, and i was feeling super depersonalized and I collapsed on the hangover after doing 7 pokeballs, i got back up but i broke my moms favorite coffee table :/, well i broke one panel of it, so everytime i walk past it, I am reminded haha. Anyways, I am definitely not doing that shit ever again and I know i proably did some damage, but I am healthy, I workout regularly, and I take care of myself, more than the average person I guess..and I knew about the risks when I did the 7 pokes, its just when you are rolling, you dont really care..you just say" fuck it ill take 2 more" haha. I've studied MDMA constantly, and I know what I am getting myself into, so I am definitely releasing way more serotonin when I do higher amounts of mdma then with a lower amount? I mean it sounds pretty obvious, but I wasnt so sure.