Excuse me for my ignorance on this subject, but what is "plugging?"
The rectal ROA, basically putting the drug up your butt hole.
Before you go off thinking he's cramming a pill up there I should tell you that most people use an oral syringe. Basically you mix your drug of choice with however much water your syringe holds, mix well, then pull the solution up into your syringe. Next you lay on your side, find the bung hole and push the syringe about (minus needles of course!) about a inch or so up your poop shooter. You have to get it far enough in there that you reach the blood vessels.
Once you're in far enough you push the plunger down, and wait about 5-15 minutes for the effects to take hold. Plugging is usually just below IV on the scale of effective ROAs. Some drugs have a really high BA through this ROA, and people like me who aren't IV users find it to be the best ROA for some drugs (like morphine for example, where you get 30% or so if you take it orally, where the rectal ROA is much higher..like at least 60% or more and it also hits you like a ton of bricks).
A lot of people have a phobia about plugging, thinking it will turn them "gay" and saying things like "that hole is exit only!". I was the same way until I came upon a large supply of morphine. I finally tried plugging it because orally it wasn't doing the trick, these days I plug every now and again. It depends on the substance I'm using and if I have 15-20 minutes to myself. Obviously plugging is something that I can't do in a social setting.
If you need more information use the search engine, we have entire megathreads on the subject of plugging.