N&PD Moderators: Skorpio
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Rectify
Bluelighter
ASPIRIN
sodium 2-acetoxybenzoate
H+ -->
2-carboxy-phenol
HNO3 / H2SO4 -->
2-carboxy-4-nitro-phenol
Sn / HCl -->
2-carboxy-4-amino-phenol
H-(C=O)-H formaldehyde, NaBH4 -->
2-carboxy-4-dimethylamino-phenol
H2(g) + Pd / Charcoal -->
4-dimethylamino-2-carboxy-1-hydroxycyclohexane
CH3OH / HCl -->
4-dimethylamino-2-carbomethoxy-1-hydroxycyclohexanetermediate
NaOH --> phenoxide intermediate
+
1-phenyl-1-chloromethan-1-one
-->
FRANZA ("synthetic cocaine") In 7 Steps.
4-dimethylamino-2-carbomethoxy-1-benzoyloxycyclohexane
Viola!