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[Rectify]

BONUS_THING
N-(2-furanylmethyl)-1-(3,4-methylenedioxyphenyl)-2-aminopropane

 

[Smyth2]

Maybe try reductively condensing amphetamine with furfural and find out what happens?

Amphetamine with furfural is Norfurfenorex, but I can't find an online synthesis.

5-(Trifluoromethyl)furan-2-carbaldehyde [17515-80-9] does exist in the database.

At least then this would be a route to Funphetamine (aka funfetorex).

 

[Rectify]

MEAN_THIOPHENE
N-(2-thiopheneylmethyl)-1-phenyl-2-aminopropane

 

[Rectify]

PROPA_PROPYL
1-cyclohexyl-1-carbomethoxy-2-methylaminopropane

 

[Rectify]

Apparently, norfurfenorex is probably a prodrug of amphetamine metabolically.

 

[Smyth2]

Hennig Ingeborg & Lindner Ernst, US3194837 (1965 to Farbwerke Hoechst AG).
Also has been done with the Embutramide precursor [93309-48-9]

 

[Rectify]

The Five:

UNO
1-phenyl-1-carbomethoxy-2-methylamino-2-trifluoromethylethane

DOS
N-(2,2,2-trifluoroethyl)-1-phenyl-1-carbomethoxy-2-amino-2-trifluoromethylethane

TRES
1-phenyl-2-methylamino-2-trifluoromethylethane

QUATTRO
N-(2,2,2-trifluoroethyl)-1-phenyl-2-amino-2-trifluoromethylethane

CINCO
N-(2,2,2-trifluoroethyl)-1-phenyl-2-amino-2-methyl-1-carbomethoxyethane

 

[unodelacosa]

The Five

You could up the ante even more and—at least in theory—attach a pentafluorothio. You know, something like this crazy bastard:

1-[(1R,5R,8S,12S)-10-(pentafluoro-λ⁶-sulfanyl)-15,16-dioxapentacyclo[10.2.1.1⁵,⁸.0²,¹¹.0⁴,⁹]hexadeca-2,4(9),10-trien-3-yl]propan-2-amine

Rolls right off the tongue, doesn't it?

Idk, could maybe call it: Pentafluorosulfanyl-dioxepane-amphetamine? Something like that?

Maybe: PENTAFLUX ANGELFLY

 

[Rectify]

You could up the ante even more and—at least in theory—attach a pentafluorothio. You know, something like this crazy bastard:

1-[(1R,5R,8S,12S)-10-(pentafluoro-λ⁶-sulfanyl)-15,16-dioxapentacyclo[10.2.1.1⁵,⁸.0²,¹¹.0⁴,⁹]hexadeca-2,4(9),10-trien-3-yl]propan-2-amine

Rolls right off the tongue, doesn't it?

Idk, could maybe call it: Pentafluorosulfanyl-dioxepane-amphetamine? Something like that?

Maybe: PENTAFLUX ANGELFLY

Should be interesting! Better check out its toxicity before tasting, though.

 

[Rectify]

SETH
1-(3,4,5-tri(trifluoromethyl)phenyl)-2-aminopropane

 

[Rectify]

FLOYD
1-(3,4-di(trifluoromethyl)-2,5-dimethoxyphenyl)-2-aminopropane

 

[Rectify]

KRISHNA
1-(3,4-di(trifluoromethyl)phenyl)-2-aminopropane

 

[Smyth2]

The alpha-trifluoromethyl-phenethylamine has been done already ages ago:

[1] BE609630 idem FR1658M idem Laszlo G Beregi, et al. US3198833 (1965 to Dite Science-Union & Compagnie-Societe Francaise De Recherches Medicales SNC, SNC Science Union & Cie).
[2] Vladimir Semenovich Karavan, et al. SU1664782 (1991).
[3] Nes, W. R., Burger, A. (December 1950). "Amine and Enol Derivatives of 1,1,1-Trifluoropropane 1". Journal of the American Chemical Society. 72 (12): 5409–5413. doi:10.1021/ja01168a012.

Alfred Burger (inventor of tranylcypromine) was the first to report it^

 

[Rectify]

It Looks Like I Am Largely Reinventing The Wheel, But Why Not?

 

[Rectify]

This One May Be My Only Real Achievement.

MAXIMUS_DECIMUS_MERIDIUS
1-phenyl-1-carbomethoxy-2-methylaminopropane

But It Was A Good One!

 

[Rectify]

1-phenyl-1-hydroxy-2-oxopropane

1-chloro-1-oxo-2-aminoethane

SISTER_CARRIE (oxophenmetrazine)
2-methyl-3-phenyl-4-oxa-5-oxopiperidine

Or Maybe

1-chloro-1-oxo-2-bromoethane

And

PPA (nor-ephedrine)

 

[Rectify]

THE_SCREAM_MACHINE (methoxypipradrol)
1-methoxy-1,1-diphenyl-1-(2-piperidinyl)methane

Yes, please!

 

[Rectify]

VIVA_LA_VIVARIN
1,1-diphenyl-1-(2-piperidinyl)methane

It Will Work.

 

[Rectify]

This Is Not

ROCKET_SCIENCE
1,1-diphenyl-2-aminopropane

Or Is It?

 

[Rectify]

TRIPHENYL
1,1-diphenyl-2-amino-3-phenylpropane