N&PD Moderators: Skorpio
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MedicinalUser247
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Smyth2
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good finding. I understand it is a remaking of https://en.wikipedia.org/wiki/1-(3-Chlorophenyl)-4-(2-phenylethyl)piperazine
JENESAISQUOAI
1-(2-phenyl-1-methylethyl)-4-(3-chlorophenyl)-piperazine
Your patent is for a completely novel compound though.Smyth2
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I read something in one of Janssen's old books that esters like this are hard to form and easily dissociate. That is the chief reason why they developed propoxyphene instead.
SANDY
1,1-diphenyl-1-carbomethoxy-2-methylaminopropane
I ❤!
Rectify
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HIGH-FLY-GUY
1-(2-phenyl-1-methyl-ethyl)-4-benzylpiperazine
I Have High Hopes For This One.Rectify
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P2P Intermediate
phenyl-2-propanone
Br2(liquid)
1-phenyl-1-bromo-2-oxopropane Intermediate
CH3CH2NH2, NaBH4
Benzylic Bromidic N-Eth-AMP Intermediate
1-phenyl-1-bromo-2-ethylaminopropane
KCN (ACHTUNG: Deadly Poison! Keep It Basic / pH = - log[H+] >> 7)
Cyano Ethylamphetamine Intermediate
1-phenyl-1-cyano-2-ethylaminopropane
H3O+ / reflux
Almost There Intermediate
1-phenyl-1-carboxy-2-ethylaminopropanea
HCl / CH3OH
CATENA (Italian, 'chain')
1-phenyl-1-carbomethoxy-2-ethylaminopropane
also known as
FOXY-CARBOMETHOXYSmyth2
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Do you know of the diphenazine patents?
HIGH-FLY-GUY
1-(2-phenyl-1-methyl-ethyl)-4-benzylpiperazine
I Have High Hopes For This One.
[1] Kalman Chem Ing Dr Lanyi, Zsuzsa Chem Ing Szabo, & Iren Csaszar, AT229873 (1963).
[1] Dr-Ing Ludwig Schusteritz & Dr Viktor Wolf, DE1041501 (1958 to Nordmark Werke GmbH).Smyth2
Bluelighter
This one looks entertaining.
P2P Intermediate
phenyl-2-propanone
Br2(liquid)
1-phenyl-1-bromo-2-oxopropane Intermediate
CH3CH2NH2, NaBH4
Benzylic Bromidic N-Eth-AMP Intermediate
1-phenyl-1-bromo-2-ethylaminopropane
KCN (ACHTUNG: Deadly Poison! Keep It Basic / pH = - log[H+] >> 7)
Cyano Ethylamphetamine Intermediate
1-phenyl-1-cyano-2-ethylaminopropane
H3O+ / reflux
Almost There Intermediate
1-phenyl-1-carboxy-2-ethylaminopropanea
HCl / CH3OH
CATENA (Italian, 'chain')
1-phenyl-1-carbomethoxy-2-ethylaminopropane
also known as
FOXY-CARBOMETHOXY