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N,N-diallyl-lysergamide.png


N,N-diallyl-lysergamide
 
1-phenyl-1-carbophenoxy-2-methylaminopropane.png


ASHTON
1-phenyl-1-carbophenoxy-2-methylaminopropane

1-phenyl-1-carbophenoxy-1-(2-piperidinyl)-methane.png


RIHANNA
1-phenyl-1-carbophenoxy-1-(2-piperidinyl)-methane

1-phenyl-1-(1-oxa-2-oxo-2-phenylethyl)-2-methylaminopropane.png


COCA_PSEUDA
1-phenyl-1-(1-oxa-2-oxo-2-phenylethyl)-2-methylaminopropane

from ephedrine and sodium phenylcarboxylate

1-phenyl-1-phenoxy-2-methylaminopropane.png


AUSTIN
1-phenyl-1-phenoxy-2-methylaminopropane

from ephedrine and sodium phenoxide

2-methylamino-3-(1-oxa-2-oxo-2-phenylethyl)-propane.png


BOLIVIAN_MARCHING_POWDER
2-methylamino-3-(1-oxa-2-oxo-2-phenylethyl)-propane

2-methylamino-3-(1-oxa-2-oxo-2-phenylethyl)-3-carbomethoxy-propane.png


PERUVIAN_FLAKE
2-methylamino-3-(1-oxa-2-oxo-2-phenylethyl)-3-carbomethoxy-propane

2-methylamino-3-carbomethoxy-propane.png


FISHSCALE
2-methylamino-3-carbomethoxy-propane
 
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1-(3,4-dihydroxyphenyl)-1-hydroxy-2-oxopropane.png


1-(3,4-dihydroxyphenyl)-1-hydroxy-2-oxopropane

1-(3,4-dihydroxyphenyl)-1-chloro-2-oxopropane.png


1-(3,4-dihydroxyphenyl)-1-chloro-2-oxopropane

1-(3,4-dihydroxyphenyl)-1-cyano-2-oxopropane.png


1-(3,4-dihydroxyphenyl)-1-cyano-2-oxopropane

1-(3,4-dihydroxyphenyl)-1-carboxy-2-oxopropane.png


1-(3,4-dihydroxyphenyl)-1-carboxy-2-oxopropane

CH2Cl2 / KOH

1-(3,4-methylenedioxyphenyl)-1-carboxy-2-oxopropane.png


1-(3,4-methylenedioxyphenyl)-1-carboxy-2-oxopropane

1-(3,4-methylenedioxyphenyl)-1-carboxy-2-methylamino-propane.png


1-(3,4-methylenedioxyphenyl)-1-carboxy-2-methylamino-propane

1-(3,4-methylenedioxyphenyl)-1-carbmethoxy-2-methylamino-propane.png


THE_L.O.V.E_DRUG in 6 Steps
1-(3,4-methylenedioxyphenyl)-1-carbomethoxy-2-methylamino-propane

This Synthetic Outline Cleverly Avoids The Harsh Reaction Conditions (either H+ or -OH with heat in reflux) Which Could Destroy The Acetal But Which Are Required For The Reaction Of An R-Cyano Functional Group To An R-CO2H Functional Group.
 
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Fun With Benzyl Piperazines!

1-(3,4-methylenedioxy-5-methoxyphenyl)-1-piperazinylmethane.png


OLLIE
1-(3,4-methylenedioxy-5-methoxyphenyl)-1-piperazinylmethane

Starting with

3,4-methylenedioxy-5-methoxy-1-allylbenzene.png


3,4-methylenedioxy-5-methoxy-1-allylbenzene, from essential oil of nutmeg

KMnO4, hot, acidic.

1-carboxy-3,4-methylenedioxy-5-methoxybenzene.png


3,4-methylenedioxy-5-methoxy-1-(chloroformyl)-benzene.png


1-(3,4-methylenedioxy-5-methoxyphenyl)-1-piperazinylmethanone.png


Then Wolff-Kishner the benzylic carbonyl.
 
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1-(3,4,5-trimethoxyphenyl)-1-piperazinylmethane.png


FREDERICK
1-(3,4,5-trimethoxyphenyl)-1-piperazinylmethane

1-(4-methoxyphenyl)-1-piperazinyl-methane.png


JENNIFER
1-(4-methoxyphenyl)-1-piperazinyl-methane

1-(3,4-methylenedioxy-6-methoxyphenyl)-1-piperazinylmethane.png


RAZ_BERRY
1-(3,4-methylenedioxy-6-methoxyphenyl)-1-piperazinylmethane

6:22 pm EST Friday Night Quitting Time.
April the 5th, 2024 Anno Domini.

Okay, just one more.

1-(4-methyl-2,5-dimethoxyphenyl)-1-piperazinyl-methane.png


DEBORAH_DEBBIE_DEB
1-(4-methyl-2,5-dimethoxyphenyl)-1-piperazinyl-methane

Starting with

2,5-dimethoxybenzaldehyde.png

2,5-dimethoxybenzaldehyde

Reduction

2,5-dimethoxytoluene.png


Aromatic carbonylation

4-methyl-2,5-dimethoxybenzaldehyde.png


Reductive Amination With Piperazine

&

Viola!
 
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1-(4-bromo-2,5-dimethoxyphenyl)-1-piperazinylmethane.png


TONY_FALINE_PENNINGTON
1-(4-bromo-2,5-dimethoxyphenyl)-1-piperazinylmethane

1,4-dihydroxybenzene --> 1,4-dimethoxybenzene etc.
 
1-phenyl-1-piperazinylmethanone.png


UNO EIN UNE
1-phenyl-1-piperazinylmethanone

1-(3,4-methylenedioxy-5-methoxyphenyl)-1-piperazinylmethanone.png


DOS
1-(3,4-methylenedioxy-5-methoxyphenyl)-1-piperazinylmethanone

1-(3,4,5-trimethoxyphenyl)-1-piperazinylmethanone.png


TRES
1-(3,4,5-trimethoxyphenyl)-1-piperazinylmethanone

1-(3,4-methylenedioxyphenyl)-1-piperazinylmethanone.png


QUATTRO
1-(3,4-methylenedioxyphenyl)-1-piperazinylmethanone
 
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1-phenyl-1-piperazinylmethanone.png


111
1-phenyl-1-piperazinylmethanone

NaBH4

1-phenyl-1-piperazinylmethanol.png

1-phenyl-1-piperazinylmethanol

1-phenyl-1-piperazinyl-1-chloromethane.png

1-phenyl-1-piperazinyl-1-chloromethane

1-phenyl-1-piperazinyl-1-cyanomethane.png

1-phenyl-1-piperazinyl-1-cyanomethane

1-phenyl-1-carboxy-1-piperazinylmethane.png

1-phenyl-1-carboxy-1-piperazinylmethane

1-phenyl-1-piperazinyl-1-carbomethoxymethane.png


SPEEDY_CINCO
1-phenyl-1-piperazinyl-1-carbomethoxymethane

I actually think this one may be fun.
 
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Most Self Reinforcing Drug I Can Think Of

1-phenyl-1-carbomethoxy-1-(morpholine-3-yl)-methane.png


MORPHO-MPH
1-phenyl-1-carbomethoxy-1-(morpholine-3-yl)-methane

1-phenyl-1-carbomethoxy-2-(morpholine-4-yl)propane.png


MORPHO_AMP
1-phenyl-1-carbomethoxy-2-(morpholine-4-yl)propane

With a dash of R-(C=O)-O-CH3.
 
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6-hydroxy-3-(methanone-1-yl)-indole.png


Commercially available.
6-hydroxy-3-(methanone-1-yl)-indole

1-(6-methoxyindol-3-yl)-2-dimethylaminoethane.png


DMT-6
1-(6-methoxyindol-3-yl)-2-dimethylaminoethane
 
1-(5,6-dichloroindole-3-yl)-2-dimethylaminoethane.png


DMT-4,5-Cl,Cl
1-(5,6-dichloroindole-3-yl)-2-dimethylaminoethane

from the commercially available

5,6-dichloro-3-(methanone-1-yl)-indole.png

5,6-dichloro-3-(methanone-1-yl)-indole
 
The Anderson Reaction:

1-phenyl-1-hydroxy-2-methylaminopropane.png


Ephedrine
1-phenyl-1-hydroxy-2-methylaminopropane

1-phenyl-1-chloro-2-methylaminopropane.png

1-phenyl-1-chloro-2-methylaminopropane

1-phenyl-1-cyano-2-methylaminopropane.png

1-phenyl-1-cyano-2-methylaminopropane

Br2 / FeBr3

1-(4-bromophenyl)-1-cyano-2-methylaminopropane.png

1-(4-bromophenyl)-1-cyano-2-methylaminopropane

1-(4-bromophenyl)-1-carboxy-2-methylaminopropane.png

1-(4-bromophenyl)-1-carboxy-2-methylaminopropane

1-(4-bromophenyl)-1-carbmethoxy-2-methylaminopropane.png


BROMO_L.O.V.E.
1-(4-bromophenyl)-1-carbmethoxy-2-methylaminopropane

In 5 Steps.
 
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1-(3,4-methylenedioxyphenyl)-1-acetyl-2-(methylamino)propane.png


TRIS
1-(3,4-methylenedioxyphenyl)-1-acetyl-2-(methylamino)propane

Say goodbye to anhedonia and depression!

1-phenyl-1-acetyl-2-(methylamino)propane.png


TETRAKIS
1-phenyl-1-acetyl-2-(methylamino)propane

What Do We Want? Euphoria!
Where Do We Find It? Various White Powders.

His ADHD Is Not Being Properly Treated.
TETRAKIS Can Help. Ask Your Doctor If TETRAKIS Is Right For You.
 
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2-oxo-pent-3-ene.png

2-oxo-pent-3-ene

Next, Br2 liquid brominates the double bond on each of its two carbons

2-oxo-3,4-dibromopentane.png

2-oxo-3,4-dibromopentane

Then, just add benzene or toluene or 1,3-benzodioxole plus Br2 and FeBr3.

Walla, 3 Productos.
I Am Not Sure What The Solvent Should Be. I'm thinking either ethyl alcohol or tetrahydrofuran.
 
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2-(1-carbomethoxy-2-aminopropyl)naphthalene.png


ALEVIATE
2-(1-carbomethoxy-2-aminopropyl)naphthalene

1-phenyl-1-carboethoxy-2-ethylaminopropane.png


MISS_PACMAN
1-phenyl-1-carboethoxy-2-ethylaminopropane

1-(2-naphthyl)-2-ethylaminopropane.png


DEPECHE_MODE (French for, 'fast fashion')
1-(2-naphthyl)-2-ethylaminopropane
 
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(1S,2S)-1-phenyl-1-carbomethoxy-2-methylaminopropane.png


DOUBLE_DEXTER_FINN_AGAIN

(1S,2S)-1-phenyl-1-carbomethoxy-2-methylaminopropane

from
(1R,2S)-1-phenyl-1-hydroxy-2-methylaminopropane.png


(1R,2S)-1-phenyl-1-hydroxy-2-methylaminopropane



Actually, I think the hydroxyl group may switch around the stereochemistry of the one spot after it undergoes a substitution reaction. I was never very good with the whole Khan Ingold Prelog (R,S) nomenclature.

Anyway, if that is the case, then this is the correct precursor:

(1S,2S)-1-phenyl-1-hydroxy-2-methylaminopropane.png


(1S,2S)-1-phenyl-1-hydroxy-2-methylaminopropane

BUT it undergoes 2 substitution reactions, so the former would be correct.

Errg, Forget Stereochemistry! All I Know Is That Ephedrine Comes In 4 Stereochemicals, And One Of Them Is Correct. Specifically, It Has A (2S).
 
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benzophenone.png


benzophenone

plus nitroethane, etc. -->

1,1-diphenyl-2-aminopropane.png


BISPHENYLAMP
1,1-diphenyl-2aminopropane

oxybenzone.png


oxybenzone

-->

1-(2,4-dimethoxyphenyl)-1-phenyl-2-aminopropane.png


MIXEDBISPHENYLAMP
1-(2,4-dimethoxyphenyl)-1-phenyl-2-aminopropane
 
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1-(1,3-dioxoindan-5-yl)-2-methylaminopropane.png


RODENTICIDE
1-(1,3-dioxoindan-5-yl)-2-methylaminopropane

This one doesn't look safe or anything. Proceed with caution, if at all.

1-(2-oxoindan-5-yl)-2-methylaminopropane.png


DANIEL
1-(2-oxoindan-5-yl)-2-methylaminopropane

1-(2-oxo-3-oxaindan-5-yl)-2-methylaminopropane.png


THE_LION'S_DEN
1-(2-oxo-3-oxaindan-5-yl)-2-methylaminopropane

May be metabolized into something gbl like.
Me So Horny! Lol.
 
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