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1,3-dimethylxanthine.png


THEOPHYLLINE
1,3-dimethylxanthine

Caffeine like compound found in tea.

7-(2-dimethylaminoethyl)-1,3-dimethylxanthine.png


MOLASSES
7-(2-dimethylaminoethyl)-1,3-dimethylxanthine
 
N-methyl-2-carbomethoxy-3-(benzoyloxy)-8-azabicyclo%5b3.2.1%5doctane.png


COCAINE
N-methyl-2-carbomethoxy-3-(benzoyloxy)-8-azabicyclo[3.2.1]octane

Doesn't last long enough. Smells great in your nostrils.

This should fix that.

N-methyl-2-carbomethoxy-3-(phenylmethaneoxy)-8-azabicyclo%5b3.2.1%5doctane.png


HUNTER
N-methyl-2-carbomethoxy-3-(phenylmethaneoxy)-8-azabicyclo[3.2.1]octane
 
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N-tert-butyl-1-(3-chlorophenyl)-1-oxo-2-aminopropane.png


WELLBUTRIN; ZYBAN; bupropion
N-tert-butyl-1-(3-chlorophenyl)-1-oxo-2-aminopropane

NaBH4

N-tert-butyl-1-(3-chlorophenyl)-1-hydroxy-2-aminopropane.png


N-tert-butyl-1-(3-chlorophenyl)-1-hydroxy-2-aminopropane

Cl-(C=O)-Cl

N-tert-butyl-1-(3-chlorophenyl)-1-chloro-2-aminopropane.png


N-tert-butyl-1-(3-chlorophenyl)-1-chloro-2-aminopropane

KCN

N-tert-butyl-1-(3-chlorophenyl)-1-cyano-2-aminopropane.png


N-tert-butyl-1-(3-chlorophenyl)-1-cyano-2-aminopropane

H3O+

N-tert-butyl-1-(3-chlorophenyl)-1-carboxy-2-aminopropane.png


N-tert-butyl-1-(3-chlorophenyl)-1-carboxy-2-aminopropane

CH3OH and HCl

N-tert-butyl-1-(3-chlorophenyl)-1-carbomethoxy-2-aminopropane.png


MCNAIR
N-tert-butyl-1-(3-chlorophenyl)-1-carbomethoxy-2-aminopropane

Only 5 Steps.

Butterflies Can Still Remember Being Caterpillars.

 
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Alternatively,

N-tert-butyl-1-(3-chlorophenyl)-1-acetoxy-2-aminopropane.png


TAMISHA
N-tert-butyl-1-(3-chlorophenyl)-1-acetoxy-2-aminopropane

Or

N-tert-butyl-1-(3-chlorophenyl)-1-methoxy-2-aminopropane.png


DAVE
N-tert-butyl-1-(3-chlorophenyl)-1-methoxy-2-aminopropane

N-tert-butyl-1-(3-chlorophenyl)-2-aminopropane.png


MARILYN
N-tert-butyl-1-(3-chlorophenyl)-2-aminopropane

All 3 From

N-tert-butyl-1-(3-chlorophenyl)-2-amino-1-hydroxy-propane.png


N-tert-butyl-1-(3-chlorophenyl)-2-amino-1-hydroxy-propane
 
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Wellbutrin, with its bulky N-tert-butyl functional group, is far from the perfect drug, but I'll take what I can get.
 
benzene.png


Propiophenone.png


1-phenyl-1-oxo-2-bromopropane.png


1-phenyl-1-oxo-2-ethylaminopropane.png

1-phenyl-1-hydroxy-2-ethylaminopropane.png

1-phenyl-1-chloro-2-ethylaminopropane.png

1-phenyl-1-cyano-2-ethylaminopropane.png

1-phenyl-1-carboxy-2-ethylaminopropane.png

1-phenyl-1-carbomethoxy-2-ethylaminopropane.png


HEADBANGERS'_BALL
1-phenyl-1-carbomethoxy-2-ethylaminopropane

via Intelligent Design

8 Steps
 
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1-(3,4-methylenedioxyphenyl)-1-carbomethoxy-1-(2-piperidinyl)methane.png


MICHAEL
1-(3,4-methylenedioxyphenyl)-1-carbomethoxy-1-(2-piperidinyl)methane

from

1-(3,4-methylenedioxyphenyl)-1-oxo-1-(2-piperidinyl)methane.png


JANE
1-(3,4-methylenedioxyphenyl)-1-oxo-1-(2-piperidinyl)methane
 
1,3-benzodioxole from Bayer aspirin:

2-acetoxybenzoic%20acid.png


ASPIRIN
2-acetoxybenzoic acid

Cl-(C=O)-Cl

2-acetoxybenzoic%20chloride.png


2-acetoxybenzoic chloride

some variation of H2(g) / Pd or sterically hindered LAH derivative

2-hydroxybenzaldehyde.png


2-hydroxybenzaldehyde (as an aside, useful for 2-MeO-amp synthesis as well)

30% H2O2, then hydrolysis with H3O+

1,2-dihydroxybenzene.png


CATECHOL
1,2-dihydroxybenzene

finally, CH2Cl2 and KOH to yield precious

1,3-benzodioxole.png


1,3-BDO
1,3-benzodioxole; 1,2-methylenedioxybenzene

This rough outline needs work, but it can be made to.
 
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1,3-benzodioxole.png


1,3-benzodioxole

1-(3,4-methylenedioxyphenyl)-1-oxopropane.png


1-(3,4-methylenedioxyphenyl)-1-oxopropane

1-(3,4-methylenedioxyphenyl)-1-oxo-2-bromopropane.png


1-(3,4-methylenedioxyphenyl)-1-oxo-2-bromopropane

1-(3,4-methylenedioxyphenyl)-1-oxo-2-ethylaminopropane.png


MDEO [3,4-MethyleneDioxy-EthylOne]
1-(3,4-methylenedioxyphenyl)-1-oxo-2-ethylaminopropane

Or do the Wolff-Kishner Reaction using hydrazine [H2N-NH2; explosive] and KOH to yield the lovely

1-(3,4-methylenedioxyphenyl)-2-ethylaminopropane.png


MDE aka EVE
1-(3,4-methylenedioxyphenyl)-2-ethylaminopropane

Likewise, using methylone instead of MDEO would give MDMA aka ADAM.
 
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1-(3,4-methylenedioxyphenyl)-1-oxo-2-methylaminopropane.png


METHYLONE
1-(3,4-methylenedioxyphenyl)-1-oxo-2-methylaminopropane

NaBH4

1-(3,4-methylenedioxyphenyl)-1-hydroxy-2-methylaminopropane.png


1-(3,4-methylenedioxyphenyl)-1-hydroxy-2-methylaminopropane

Then the Williamson Ether Synthesis utilizing NaOMe

1-(3,4-methylenedioxyphenyl)-1-methoxy-2-methylaminopropane.png


RALPH
1-(3,4-methylenedioxyphenyl)-1-methoxy-2-methylaminopropane

Likewise,

1-(3,4-methylenedioxyphenyl)-1-methoxy-2-ethylaminopropane.png


LAUREN
1-(3,4-methylenedioxyphenyl)-1-methoxy-2-ethylaminopropane
 
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benzaldehyde.png


benzaldehyde

Plus CH3OH, CH3CH2-NO2, CH3NH2 or cyclohexylamine -->

1-(2-nitroprop-1-ene-yl)-benzene.png


1-(2-nitroprop-1-ene-yl)-benzene

Plus NaBH4 in CH3OH

1-phenyl-2-nitropropane.png


1-phenyl-2-nitropropane

Plus Sn / HCl reflux in CH3OH

1-phenyl-2-aminopropane.png


AMPHETAMINE
1-phenyl-2-aminopropane

CH3CH2-OH can be used as the solvent instead of methanol, but the yields might be lower.
 
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N-allyl-1-phenyl-1-carbomethoxy-2-aminopropane.png


ALEXANDER
N-allyl-1-phenyl-1-carbomethoxy-2-aminopropane

The N-allyl amphetamines feel a bit toxic because their necessary dose is rather large.
 
Speaking of "Greats,"

N-allyl-1-(3,4-methylenedioxyphenyl)-1-carbomethoxy-2-aminopropane.png


KATHRYN_KITCHENS
N-allyl-1-(3,4-methylenedioxyphenyl)-1-carbomethoxy-2-aminopropane
 
1-(4-chlorophenyl)-2-aminopropane.png


HILLARY
1-(4-chlorophenyl)-2-aminopropane

They say this is toxic, and it may be, but they also said the same thing about mdma. Probably a lot of drugs are.
 
2-(1,4-dimethoxy-naphth-2-yl)-1-aminoethane.png


SKORPIO
2-(1,4-dimethoxy-naphth-2-yl)-1-aminoethane

My Magic 8-ball Says, "Signs Point To Yes." I Think It's In PiHKAL.

I had to have plastic surgery once, too. I had an embossed cyst the size of a golf ball on my left cheek. So humiliating, but I am very grateful to that doctor. He only charged $500.
 
1-(3,4-methylenedioxy-5-methoxyphenyl)-1-carbomethoxy-1-(2-piperidinyl)-methane.png


iWISH
1-(3,4-methylenedioxy-5-methoxyphenyl)-1-carbomethoxy-1-(2-piperidinyl)-methane

or maybe this instead

1-(3,4-methylenedioxy-5-methoxyphenyl)-1-carbomethoxy-2-aminopropane.png


SAINT_PETER
1-(3,4-methylenedioxy-5-methoxyphenyl)-1-carbomethoxy-2-aminopropane
 
Can you make a Drawing of LSD with a Methylene dioxy attached to the heal... The 1,2 of the LSD molecule ? I'd like to see what that actually looks like. Thanks.
 
Okay, gimme un momento, si vous plait.

1,2-methylenedioxy-N,N-diethyllysergamide.png


1,2-MD-LSD
1,2-methylenedioxy-N,N-diethyllysergamide

That molecule is not even about to happen. Way too unstable.
 
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