I quess that you would have strong 5ht1a activity so serotonin anxiolytic high. Lower dopamine and noradrenaline levels so low energy/mood. I think it simply places you in a Slow mellow and sleepy mood neithr fun or scary. The biggest dose i have ever taken is 100mg (some goes up to 200 and more) and didnt felt alot until i woke up 30 mins later than i usually do(wow what a great night i gained 30 mins..). I have precoce wakeing insomnia and difficulty falling asleep so that might explain my ''natural'' tolerance to sedatives altho this one is a real weak one. I use it as sometimes sleep aid but mostly to replace benadryl or other anti histamine that are to anticholinergic for some1 trying to supplement A-GPC and noopept.What kind of effects would come about a high dose of hydroxyzine if forced to stay awake? Similar to diphenhydramine?