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Recovery of morphine from urine

S

stvip

Bluelighter
Joined
Jul 30, 2005
Messages
39
With regards to this thread:
http://www.shroomery.org/forums/sho...4530636&Words=&topic=&Search=true#Post4530636

I am looking for a simple technique which should focus on
1. Ease of application for the average person. There are easy techniques involving GC-MS (drug testing protocols) which one could use, but the target audience is composed of people who think that must be the latest from Microsoft, the company which built their computer.
2. Efficiency.
3. Aesthetics. The product shoulod be something most people will not find objectionable.

Right now the method would consist of acidifying the solution, cooling and filtering.
Any ideas?
 
Not really relevant, but it's not intended for me. Codeine phosphate (single agent) is OTC and reasonably cheap in my country, and I'm also cultivating M. speciosa, so such measures would be rather pointless (I also use regularly but infrequently, to avoid any tolerance or dependence, so ready availability isn't an issue). However, for others, if a safe clean product can be derived, the potential is obvious.
Purified urine recycling for drinking is already practiced in several military or hiking situations. Many Indians practice this for (supposed) health reasons (and thus urine drinking has recently become another fad in the US). And that's unpurified, non-extracted.
Any informative replies?
 
Well dainty girls, you might want to quit munching on those horse urine extracts known as contraceptive pills. Or are equesterian excrections perfectly fine to ingest as long as it isn't White Horse?
The atoms of the alkaloids are dirty anyhow - they come from all the disgusting manure and dirt the poppy plants ate up. Dirty, dirty plants.
 
yeah if that makes you feel better about drinking piss then go for it man.
 
I know a chemist who claims he used to pull methamphetamine out of 5 gallon buckets of piss that would collect at his house from customers.....he claimed around an ounce per bucket.
 
^ Yep, from a dose of methamphetamine, most would be pissed out as either unchanged meth or as its primary metabolite, amphetamine.

The idea of having 5 gallon buckets of other people's piss sitting around the house doesn't sound nice though. Depending upon what you've been eating, the piss can smell pretty rank, and that before even considering what it'll smell like once airbourne bacteria get into it and start breaking it down.
!

One thing I mentioned in a thread I started a while ago, you could always eat a load of codeine along with a load of grapefruit juice (to prevent N-demethylation) and find that your body had done the difficult work and turned codeine into morphine (well morphine-6-glucuronide), or alternatively dihydrocodeine into dihydromorphine-6-glucuronide.

Turn your body into a clandestine lab!
 
N-demethylation is also responsible for normorphine, which, at this point, is an undesirable metabolite.

Make alkaline with 0.880 ammonia & extract with chloroform or methylene chloride. You can't use sodium hydroxide as morphine forms a phenoxide salt with NaOH.
Click to expand...

How about boiling in acid to hydrolyze the glucuronides and denature proteins, precipitating out the proteins and filtering, then basifying and separating with a nonpolar? I think such a procedure would retain urea, which isn't necessarily bad. What else would it pull?

Here is an example of a lab procedure for liberating morphine and codeine in urine from their glucuronide conjugates and clearing it from some junk:
http://www.biochemicaldiagnostics.com/univurinaryopiates.html
 
About NaOH - several morphine isolation methods use it to basify the solutions. For example, US Patent 6,054,584. As for the extracting the freebase into a nonpolar layer, wouldn't that also extract any or all of the following: urea, creatinine, uric acid, other constituents? The average Occidental person seems to have (regardless of justifiability) a very strong aversion towards dealing with their own urine, so the method must eliminate the characteristic odour and colour.
 
I'm dying to find out if this works for Oxycodone -> Oxymorphone. I think the problem with this one is that most people have not tried Oxymorphone and/or have no access to chemical analysis equipment so they have no way of finding out if it worked or not :\
 
Anybody know the pKa of the phenolic OH group in morphine?
Click to expand...

The Merck Index does: pKa: pKb at 20° = 6.13; pKa 9.85

See the US patent I mentioned for a modern apprpach to extracting morphine (from opium). For urine, however, I believe a different technique is required. MI also lists creatinine as practically insoluble in acetone, ether and chloroform, which is good. Uric acid is also insoluble in ether, but that's not a commonly available solvent (for the common person, anyhow), and I think eliminating uric acid isn't important (in fact, one could speculate that it could help perserve the morphine).
 
No, the common person (in India, China and other Asian countries, which just might make that statistically the common person worldwide) drinks their piss straight. Siberian tribes, and other populations who were familiar with Amanita muscaria, had a practice similar to the one proposed here.
Actually, since urine collection following a dose should go on for about 24 hours, the volume and lack of freshness mandates an extraction anyhow, regardless of ethnic practices (unless there's some very weird tribe somewhere with defective olfactory genes). Not long ago, the average female person sure did ingest urine extracts - from horses (apparently now the hormones are synthetized). For what it's worth, I've never drank my own urine, fresh or stale, extracted or otherwise, so I don't know what I'm missing. If, however, I ever saw medicinal benefit from such, I wouldn't hesitate (some claim morning urine is a good source of extra melatonin, but junk science abounds in "urine therapy" and other fads).
The common person suffering from refractory depression, chronic pain and/or opiate addiction often ingest truly horrifying substances (such as street drugs - a most disgusting notion). Balking at purified alkaloids from one's own urine? Perhaps only in the most severely brainwashed (against bodies and their functions) cultures, where body dysmorphic disorder is actually the norm, such as the US and parts of Europe.
Anyhow, mini-rant over - as I said, I have no use for this myself. It is aimed to be of help to the forementioned populations, who are probably the largest, and one of the most aggrieved, victim group of the War on Drugs. It is one of several projects I am investigating. If you have a better suggestion, let's hear it. Otherwise, I feel safe imagining you cowering in fear in the corner over the horrible, terrifying damage inflicted to your psyche by accidently viewing Janet Jackson's, shocked gasps everywhere, exposed nipple on TV, and thus being unable to post.
 
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