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Recouping ketamine from oily substance

T

torillo

Greenlighter
Joined
Feb 7, 2009
Messages
4
Hi. This is my first post, I know, but I have to ask. I managed to get a decent sample of ketamine that was mixed with an oily substance. The problem is separating it from the oil. THe oil is solid at room temp, but if heat is applied, then the ketamine goes to the bottom of the beaker, to which I proceed to filter via a 50 micron nylon mesh. I am still left with Ketamine and some oil. I sigured that since K is soluble in water, just adding warm DI water would dissolve the K and leave the oil behind. THe proble is, the K is not dissolving at all! It forms a precipitate at the bottom of the beaker and it does not dissolve at all. There are minute ammounts of oil still present in the water wit the K, but it does not forma clear division between water an oil, to a point where I could just use a separation funnell and be done with it. I am frustrated beying belief on trying to fix this.

I noticed that is I apply too much heat to the paste/k mixture, it forms a solution. Once you let it cool down, the K crystals form at the bottom, but there is stil K dissolved in the oil, I know caue I tasted it and got a tad high a few hours after it. I have repeated the process to no avail, with no success on diluting the K in the warm DI water.

I figure I was not using enough water to dissolve the ammount of K, but I habve used plenty for it to work. My guess is that the K is till slightly mixed with the oil, but even if I boil the water/k/oil/solution, no clear separation form.

I'm thinking I got K Base, and not K HCl, but then again, why wuold I get slighlty high by just tasting it. I feel a tad bit drunk, as I had 4 beers, ver relaxed. Any help is appreciated. Thanks
 
Could be placebo? If I had to extract it I would say heat it to the point where it is dry of any water except the oil then add HCl and then heat it again to dry it of the water that comes with HCl (unless you gas the HCl in, but that's a whole other level of danger that if you can't figure out you shouldn't attempt) and then filter the precipitate then wash it with a solvent that it isn't soluble in. If it's ketamine base and the HCl is water soluble, that should work
 
reading

Swim has been reading more and more and it seems that K is liposoluble. Even though he keeps boiling it, the coconut oil does not seem to go away completely. The K is there, but it has an oily residue to the touch. I assume that because of this residue, it cannot be put into aquous solution.

I am trying to find a lipophylic compound that would attract the coconut oil and leave the K alone. Believe it or not, I have thought od adding Xenical to a small portion to see if it works...out of desperation.....LOL. I did add some to sunflower oil and water and the Xenical sure enough encapsulated the oil.

Swim is not a chemist, but is desperate to fix this problem. Thanks guys.
 
Sounds like ketamine freebase mixed with some kind of oil. Add a little water and hydrochloric acid and the ketamine will move into the water, then you could separate the oil and evaporate the ketamine salt (water layer) (as said before). Ketamine freebase is not very water soluble at all.
 
Lol

OK. So I misread one post and thought that toluene would dissolve Ketamine HCl. It seems I am wrong. The "ketamine" did go into solution and the oily residue did go away after several hundred toluene washes. I get some of the crystals and the do not dissolve in water at all. Iam thinking I got Ketamine base., no other way around it.

How shall I got about making it into HCl. I have done cocaine into HCl before, but I am unsure if its the same procedude. Thanks
 
Given that ketamine has a secondary amine, and you are getting a water-insoluble precipitate, I would recommend dissolving the solid in minimal anhydrous acetone, and adding dropwise concentrated HCl. Cooling the solution in a salt water ice bath should ppt out the ket-HCl. This is all based on the fact that ketamine HCl is insoluble in acetone...if it is soluble, then that won't work....Also, freebase amines are still readily bioactive, in some cases even more so-for example methaqualone freebase and especially amphetamine freebase. Let me know what you do.
 
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