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Rarest drugs you've done?

letsparty said:
Yessir. Sealed and from a trusted source ..
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Well, in all likelyhood it was alprazolam.

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I can well understand that if your bottle didn't come with the dose information listed, it's easy to wonder if a dose is a drop or an entire dropper full of the stuff.

I'm just glad you are able to warn others.
 
unodelacosa said:
Well so Namenda and Dilaudid are not rare drugs, and smoking opiate-containing tablets is common in some places like South Africa. However I will admit: I've personally never talked with someone who's had that exact combo. How was it? Memantine can be a horrible, long-lasting time if one takes too much. And there are many Dilaudid users who would argue that smoking it is a waste of good drugs (bc it's not IV), but they're missing the point entirely. Seriously, what was the high like in your words? I have some memantine now… is it worth smoking it in your opinion?
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I had powdered hydromorphone, which my friend ( chemist ) bring from work.
Smoking hydromorphone like when u smoke weed via gravity bong, was instant 1 second after releasing smoke u Will feel all your body and limbs becoming very relaxed, no worry in the world, it was much, much better than for example smoking high quality crystal meth and u can't achieve high like i did when i smoked that powder by eating or smoking pills. No fillers, just 97 + % hydromorphone powder.
Memantine is more complicated, very dose dependant. 20mg daily and it makes everything stronger but it is very clear, subtle-dissociative feeling hiding behind whatever u take throught the day.
100mg memantine was like low dose dopaminergic stimulant + low dose ketamine, lasting 2 days. 20 mg is very good for anxiety, depression, cognitive fog. But DXO/DXM , lasting only few hours, can produce much more intense high. I also combined DXM and memantine and i was tripping, music was soo good and everything had suddenly other meaning, i mean it completely changed my point of view on everything. Very magical. I took modafinil with memantine too, it nicely diminish peripheral effects of modafinil and turn it into more head-high stimulant/nootropic.
 
@WellTram - I've only ever seen it done once, but vaping freebase methadone is evidently a totally different animal to the 1mg/mL linctus used in the UK in replacement therapy.

All I know is the person who did it evidently drew one other person who was prescribed the linctus and they were both seen hanging around pharamcies buying up all they could get. Then they just disappeared. No idea what happened there. Nothing good, I suspect.
 
You can easily find memantine powder online from nootropic suppliers. I’ve used it to help with withdrawals. From what you describe, it sounds about the same as oral dosing. Memantine has good oral bioavailability (100%), so the only benefit of smoking would be more rapid onset or a rush, and it doesn’t sound like either applies.
As far as smoking hydromorphone, never done that but I have smoked plenty of heroin, which is almost as good an intravenous. However, it’s wasteful, so I preferred IV, though I no longer indulge.
 
4DQSAR said:
Well, in all likelyhood it was alprazolam.

postimg.cc

1 — Postimages

postimg.cc postimg.cc

I can well understand that if your bottle didn't come with the dose information listed, it's easy to wonder if a dose is a drop or an entire dropper full of the stuff.

I'm just glad you are able to warn others.
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Yea I was told to take a drop....i.took a whole dropper full and dabbed several.blues.......that's probably why I lost three days of memory and was probably the closest to death I've been..
It's for sure not a safe combination in any amount .
 
General alcazar said:
You can easily find memantine powder online from nootropic suppliers. I’ve used it to help with withdrawals. From what you describe, it sounds about the same as oral dosing. Memantine has good oral bioavailability (100%), so the only benefit of smoking would be more rapid onset or a rush, and it doesn’t sound like either applies.
As far as smoking hydromorphone, never done that but I have smoked plenty of heroin, which is almost as good an intravenous. However, it’s wasteful, so I preferred IV, though I no longer indulge.
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Yes i could IV hydromorphone too but i never did. We had so much of it that i was smoking it constantly every day, all the tíme the pipe was in my hand and little golden box of light-brown powder in my pocket. I wasted a lot ! I loaded casual weed pipes when i was smoking it at home, nodoby noticed that interesting smell. But i couldn't use gavity bong in front of my parents at that time.

We also had powder form oxycodone which was quite dissapointing for me and also good old morphine, which was MUCH weaker than hydromorphone. But still stronger than oxy powder smoked/snorted. Hydromorphone gave me unlimited energy and power, morphine just made me sleeping. Oxy was weak. Right now i took 100mg ER oxycodone oraly and if i double IT, ( 200mg ) oraly will produce the same high just a 2-3 hours after eating it, but it lasts for 8-10 hours...strange that ER oxy can't work for 12 hours but dihydrokodeine ER lasts 12+. And, the WD from smoking that hydromorphone was 7 days of nasty torture but still not as horrible as tramadol + alorazolam WD. For some reason, benzos and tramadol are worst to WD from.
 
WellTram said:
We also had powder form oxycodone which was quite dissapointing for me....
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Well, two decades ago researchers knew that about 10% of orally consumed oxycodone was converted by the liver into oxymorphone (which is ten times more potent than oxycodone). BUT all those years ago it was believed that the oxymorphone wasn't actually contributing to the analgesic effects of oral oxycodone. But a cpuple of decades later researchers discovered that HALF of the analgesia was actually due to the (very) active metabolite.

In fact, a few papers suggested it might actually be MORE than half. But as we know, genetic differences mean some groups are classed as 'poor metabolizers' and others as 'super metabolizers so it's unclear if that might explain different papers giving slightly different results. But for most people it's around 10%,

So any sort of parentheral administration is going to bypass the first-pass metabolism oxycodone undergoes if consumed orally. I've never tried it but I've been told that the character of the 'high' from parentheral use of oxycodone is vastly different to oral consumption BUT overall the latter is the more potent ROA.

I did go through all this with someone on another thread. They were reluctant to believe me and thought a link to the Wikipedia page on oxycodone was like playing an ace. It wasn't. That's one problem with Wikipedia. Since nobody is PAID to maintain it, almost nobody does. Another is that ANYONE can add a new page and if they make a mistake, it's almost never picked up on. Like the page on nitromethaqualone which gets the structue wrong. But there are many more issues so I mostly avoid it.
 
4DQSAR said:
Well, two decades ago researchers knew that about 10% of orally consumed oxycodone was converted by the liver into oxymorphone (which is ten times more potent than oxycodone). BUT all those years ago it was believed that the oxymorphone wasn't actually contributing to the analgesic effects of oral oxycodone. But a cpuple of decades later researchers discovered that HALF of the analgesia was actually due to the (very) active metabolite.

In fact, a few papers suggested it might actually be MORE than half. But as we know, genetic differences mean some groups are classed as 'poor metabolizers' and others as 'super metabolizers so it's unclear if that might explain different papers giving slightly different results. But for most people it's around 10%,

So any sort of parentheral administration is going to bypass the first-pass metabolism oxycodone undergoes if consumed orally. I've never tried it but I've been told that the character of the 'high' from parentheral use of oxycodone is vastly different to oral consumption BUT overall the latter is the more potent ROA.

I did go through all this with someone on another thread. They were reluctant to believe me and thought a link to the Wikipedia page on oxycodone was like playing an ace. It wasn't. That's one problem with Wikipedia. Since nobody is PAID to maintain it, almost nobody does. Another is that ANYONE can add a new page and if they make a mistake, it's almost never picked up on. Like the page on nitromethaqualone which gets the structue wrong. But there are many more issues so I mostly avoid it.
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So, i should rather eat that powder oxy. In fact, oxycodone has almost simmilar affinity to mu opi receptors as O-DSMT.
But tramadol, and Its metrabolite O-DSMT is somehow more effective and half-life od O-DSMT is 8 hours and it rise when u take another dose. They should use only O-DSMT, but they belived that slow onset caused by metabolizing tramadol into active metabolite is great strategy to market it as a not addictive and not popular for addicts. Well, they created dangerous and VERY addictive opioid with monoaminergic affects.
 
WellTram said:
So, i should rather eat that powder oxy. In fact, oxycodone has almost simmilar affinity to mu opi receptors as O-DSMT.
But tramadol, and Its metrabolite O-DSMT is somehow more effective and half-life od O-DSMT is 8 hours and it rise when u take another dose. They should use only O-DSMT, but they belived that slow onset caused by metabolizing tramadol into active metabolite is great strategy to market it as a not addictive and not popular for addicts. Well, they created dangerous and VERY addictive opioid with monoaminergic affects.
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Yes. Well, sort of.

I suggest the reason why oxycodone was selected was that researchers assumed that people would realize that it's more active orally... but apparently not.

Frankly, I'm uncertain that powder is best. I always advise people to take medication as prescribed as the virtue is that formulations are designed optimize bioavailability and importantly, the same dose every time. So while powder will likely be a bit faster than an IR pill, it's also more susceptiable to other factors and might not provide the same bioavailability each time.

In short - just take as prescribed.
 
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Any negative after effects? I read that someone suggested Seconal gave him a hangover…

How is the addiction factor? I know that it can be severe with benzos…
 
red22 said:
Any negative after effects? I read that someone suggested Seconal gave him a hangover…

How is the addiction factor? I know that it can be severe with benzos…
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Negatively, yeah you feel like you have a bad hangover and you won't remember at least 60% of what happened depending on the amount you smoked.

There is no addiction factor. Unless you like being smashed out your mind constantly, not being able to walk and talk and just drooling over yourself. Nah it's a weekend thing. So to speak
 
Interesting that Quaaludes and Seconal, supposedly more enjoyable than benzos, induce hangovers, while benzos don't.

I question that it is a "bad hangover" because alcohol just has a sledge hammer effect on the body that isn't comparable to bona fide drugs.

Also, I asked an older guy if Quaaludes have a hangover and he said no…
 
The hangover effect is more just a headache and waken up confused and having to take 30 min to replay yesterday in you head with a pounding head but that's it. But I use to smok3 H afterwards ( after an mandrax session) so never really had an hangover that's more then 3/10. But yeah not comparable with an alcohol hangover
 
Coffeeshroom said:
There is no addiction factor.
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Actually, methaqualone is just as capable of forming physical dependence as the barbiturates it was meant to replace. Just like barbitutates, users develop tolerance to the effects of methaqualone but not to it'a other activities. I understand methaqualone overdose can produce seizures but more often people would fall asleep and then choke on their own vomit. But that was mosty consuming the drug orally.

It's always it's HOW the drug is used and the format(s) it's sold in.

I note Mandrax sells for between £1.30 to £3.30 per pill (based on recent UN figures and today's exchange rate). Now that sounds cheap but I'm not sure about average wage in SA.
 
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