(quich one here )Midazolam is it worth snorting or clonazepam?

[pally pete]

is it wortth snorting midazolam? ive heard mixed reports...and do i prepare? just crush and snort|?

 

[NeighborhoodThreat]

I don't know about midazolam (it is water soluable IIRC) but snorting clonazepam is a waste. Oral use is the best way to go with clonazepam.

 

[nAON]

Yeah, just crush and snort if you have the pills. I didn't notice much difference from snorting, not worth the bad taste imo

 

[Dr Rxpert]

oral is the best roa.

 

[laCster]

don't see how klonopin is involved?

 

[Oxide]

Well, from doing a little research I've seen a few studies that cite oral bioavailability of midazolam to be about ~27-35% due to extensive first-pass metabolism.

Intranasal routes have about a ~75%+ bioavailability.

Source one.

Source two.

Clonazepam, however, is not worth snorting at all.

 

[effie]

Good work! Okay, this has been answered I think midazolam is one of the few water-soluble benzos.. all the rest, definitely a waste insufflating. Crush and snort sounds like all the prep you'd need, can't think of anything else. Remember there will be a load of inactive crap in there too that you will be putting into your sinuses (as with snorting any pill). Also, with a much higher bioavailability, adjust your dose accordingly.

Closed as answered but pm me if you have any queries