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Questions for TheGamer, about TLC

D

Drug Dustbin

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Joined
Jan 18, 2000
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So, once again I'm interested about your TLC systems.
smile.gif

What is the developing agent you are using?
Acidified potassium iodoplatinate solution?
If I remember correctly you are using methanol-ammonia
as the solvent system. If my memory serves me right, in this system
the Rf-values of MDMA and methamphetamine are too close to be
differentiated. Do they give different colours when sprayed with the
developing agent? I have seen some studies where gallic acid or
chromotropic acid has been used as confirmatory reagents for
methylenedioxy groups. Have you heard about these?
 
Welcome Back!
We're using 1.5% Methanol:Ammonia solution as the mobile phase solution.
The difference in rf values between methamphetamine->MDA->MDMA are
0.46 , 0.50 , 0.55
So yes, they are close, but still when you look at the physical measurements in millimetres, they are
59.8mm, 65mm, and 71.5mm
These are still large enough differences to see two separate spots.
We use Iodine staining for a developing agent, which does NOT cause different colours.
Here's a good link which I've just found... Its from the UN (1985) and it seems to have a lot of good information for amphetamine detection, including the "N-Methalayted" and "hallucinogenic" amphetamines.
http://www.undcp.org/bulletin/bulletin_1985-01-01_1_page008.html#f009
Still researching...
smile.gif

TheGamer
 
Thanks, TheGamer. The link you gave is to an article published
on Bulletin on narcotics (I have photocopied it once). Within
couple of days I'm getting the following article, which sounds
quite interesting:
Bailey, K., By, A.W., Legault, D. and Verner, D. Identification of
the N-Methylated Analogs of the Hallucinogenic Amphetamines and
Some Isomers. J.A.O.A.C. 58 62-69 (1975).
MDMA and four analogous methamphetamine derivatives (corresponding to 2-,
3-, and 4-methoxyamphetamine (MA) and 3-methoxy-4,5-methylenedioxyamphetamine
(MMDA)) were synthesized and spectroscopically characterized. The synthesis was
from the corresponding phenylacetone through the Leuckart reaction with
N-methylformamide. The reported m.p. (of the hydrochloride salt) is 147-8 degrees C.
The U.V., NMR, IR and mass spectral data are presented. Rf values (five systems) and
GC retention times (four systems) are also given.
I'll inform you if I find something interesting...
 
Wonderful... this could really help!
(especially the 4-MA one!)
BTW: to anyone reading this and didn't know 4-MA is 4-methoxyamphetamine or, p-methoxyamphetamine or PMA... its all the same drug!
TheGamer
[This message has been edited by TheGamer (edited 08 January 2001).]
 
Sigh, nothing special in that article. They used six different kinds
of mobile phases, but not methanol-ammonia.
frown.gif

I think I have already posted Rf-value for PMA...
 
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