Blue_Velvet
Bluelighter
Hi,
I'm not sure if this should be in Other Drugs or Health but I'll be damned if that stops me from posting this. Anyways I figure that there is a greater interest in phamacology in this forum. I am not takeing beta blockers or alpha blockers, my experience with them comes from a few month stint with Inderal (propranolol) at a low dose (20 mg. twice a day). I am asking these questions out of curiosity, hopefully some other Bluelighters will find this thread interesting as well, or better yet helpful. I have searched Bluelight (there were some very interesting threads on the issues below), as well as Medline, and Deja News so I think these questions should be valid.
The first thing I'm curious about is the fact that the beta blocker Inderal is known to potentate Xanax. I imagine that there is not much, but a little, of additional sedation when any beta blocker and benzo is mixed but I'm referring to a much stronger interaction which occurs between Inderal and Xanax, the Xanax becomes stronger but more importantly longer lasting. Why does this happen? Do the two drugs compete for an enzyme to be metabolized? It's not because of Inderal's effect on the GABA system because the above affects don't occur when other beta blockers and benzos are mixed (this is a BIG assumption)?
My second consideration is toxicity. People with cardiac problems would be taking the most, correct? What's the typical high end dose? More interesting are the reports of toxicity when beta blockers and amphetamines are combined. I don't mean people overcompensating for the dampening effect beta blockers would have on speed or the beta blockers blocking warning signs of danger. There seems to be concern over an additional danger that presents itself when the two are mixed that I haven't found an explanation for. Beta blockers are not indicated for amphetamine overdose, right? How about beta blockers and coke?
My next question regards a common off label use of beta blocks. Sometimes beta blockers are used to combat situational anxiety, many classical musicians use the drug this way. I know the goal here is to block some of the effects of adrenaline. Continuing in this direction is someone on beta blockers physically weaker or unable to reap the full benefits that come with increased adrenaline. Would a beta or alpha blocker possibly make someone less violent.
A few years ago for a short time I was put on the beta blocker Inderal as a propalaxive for migraines. Anyone know why the M.D. thought this had a chance in hell of working? I figure she gave it a shot because a low dose of inderal is more benign than an anticonvulsant, the obvious choice to prevent migrains. I'm thinking either Inderal is vasioconstrictive, which I doubt, or her theory was that a lower blood pressure would yield less migraines.
I'm very interested in comments from people who have taken either beta or alpha blockers, esp. how they made you feel mentally and if you or anyone noticed a change in your personality. Would these drugs have an affect on antisocial behavior? Have they ever been used this way? They are much kinder than most drugs used for that perpose.
I know asked a lot of questions and am all over the place. I also doubt if there are clear cut answers to all these questions, but if you have any pertinent information it would be much appreciated.
I'm not sure if this should be in Other Drugs or Health but I'll be damned if that stops me from posting this. Anyways I figure that there is a greater interest in phamacology in this forum. I am not takeing beta blockers or alpha blockers, my experience with them comes from a few month stint with Inderal (propranolol) at a low dose (20 mg. twice a day). I am asking these questions out of curiosity, hopefully some other Bluelighters will find this thread interesting as well, or better yet helpful. I have searched Bluelight (there were some very interesting threads on the issues below), as well as Medline, and Deja News so I think these questions should be valid.
The first thing I'm curious about is the fact that the beta blocker Inderal is known to potentate Xanax. I imagine that there is not much, but a little, of additional sedation when any beta blocker and benzo is mixed but I'm referring to a much stronger interaction which occurs between Inderal and Xanax, the Xanax becomes stronger but more importantly longer lasting. Why does this happen? Do the two drugs compete for an enzyme to be metabolized? It's not because of Inderal's effect on the GABA system because the above affects don't occur when other beta blockers and benzos are mixed (this is a BIG assumption)?
My second consideration is toxicity. People with cardiac problems would be taking the most, correct? What's the typical high end dose? More interesting are the reports of toxicity when beta blockers and amphetamines are combined. I don't mean people overcompensating for the dampening effect beta blockers would have on speed or the beta blockers blocking warning signs of danger. There seems to be concern over an additional danger that presents itself when the two are mixed that I haven't found an explanation for. Beta blockers are not indicated for amphetamine overdose, right? How about beta blockers and coke?
My next question regards a common off label use of beta blocks. Sometimes beta blockers are used to combat situational anxiety, many classical musicians use the drug this way. I know the goal here is to block some of the effects of adrenaline. Continuing in this direction is someone on beta blockers physically weaker or unable to reap the full benefits that come with increased adrenaline. Would a beta or alpha blocker possibly make someone less violent.
A few years ago for a short time I was put on the beta blocker Inderal as a propalaxive for migraines. Anyone know why the M.D. thought this had a chance in hell of working? I figure she gave it a shot because a low dose of inderal is more benign than an anticonvulsant, the obvious choice to prevent migrains. I'm thinking either Inderal is vasioconstrictive, which I doubt, or her theory was that a lower blood pressure would yield less migraines.
I'm very interested in comments from people who have taken either beta or alpha blockers, esp. how they made you feel mentally and if you or anyone noticed a change in your personality. Would these drugs have an affect on antisocial behavior? Have they ever been used this way? They are much kinder than most drugs used for that perpose.
I know asked a lot of questions and am all over the place. I also doubt if there are clear cut answers to all these questions, but if you have any pertinent information it would be much appreciated.
![:\](https://bluelight.org/xf/BL_Images/Orig_Emoji/wrygrin.gif "wry grin :\")
) 