outerealmseekadventr
Greenlighter
- Joined
- Sep 18, 2026
- Messages
- 17
I came across a very helpful post on another forum. I then came across another comment on another forum about mescaline citrate and researched that its final PH is around 6. With acid reflux I was trying to get the final mescaline salt to around as neutral as possible . Here are the comments in quotes:::
"The whole concept of excess acidity is a nonsense that proliferates throughout internet forums. The vast majority of freebase alkaloids
and acids are liquids that only become a solid when they bond to create the neutral salt. As the salt form is neutral it carries no net
positive (or negative) charge making it impossible to be too acidic or too basic. The only way an end product salt could be slightly
acidic is through poor quality reagents, such as the metals in consumer grade hardware store hydrochloric acid forming a side product.
This is one of the reasons it’s preferable to do a recrystallization cleaning up the end product."
Here is a comment about citrate though:::::::;
"It is not acidic because there are traces of citric acid.
"Citric acid has 3 organic acid groups -COOH. Mescaline only occupies one of them when making the monomescaline salt.
The two extra acidic groups in solution will end up donanting some H+ lowering the pH. This is coming from the salt itself.
All this can be calculated using the various Pkas of citric acid and mescaline."
Question: With the final mescaline citrate PH from Cielo or another tech being around 6, when drinking the mescaline citrate after the extraction, could you just drink it and simply drink it with some baking soda to make it neutral? Would it be more complex then that?
From the first comment:
"We are discussing the salt chemistry of compounds containing carbon-hydrogen bonds, these alkaloids must be protonated and made neutral
to become a sold salt so it can be extracted and purified, we call this Organic Chemistry. Can salts used for Inorganic Chemistry be acid or base,
yes primarily when their elements are disassociated in water (aq). When people talk about acid or base salts they’re talking about them dissolved into water
AKA: aqueous (aq) solutions Maybe we need to better define what an acid/base is in drug chemistry."
"Looking at HCl and carbonate ions and how they interact in water to makes acids and bases."
'When two atoms or molecules form a union, they are deemed to be “conjugated” In the case of HCl this gas dissolves in water where the Hydrogen (H) and chlorine (Cl)
disassociate, coordinating with water to become hydrochloric acid HCl(aq). This new combination is called a conjugate acid-base pair."
"Yeah, probably paranoia HCl salts are neutral, CO2(aq) a weak acid and the amino group a strong base. I’d be way more concerned about it being too basic as the
crystals turn to mush on standing with exposure to the air."
"As I said before I doubt that would be necessary, if you have it recrystallized, I don’t see how it cold be anything other than neutral."
Question: I didn't put the whole comment, and I was asking other questions too, I know other salts can be positive or neutral, seems mescaline salts are neutral except for citrate even after the wash crystallization?
With the final mescaline citrate PH from Cielo or another tech being around 6, when drinking the mescaline citrate after the extraction, could you just drink it and simply drink it with some baking soda to make it neutral? Would it be more complex then that?
"The whole concept of excess acidity is a nonsense that proliferates throughout internet forums. The vast majority of freebase alkaloids
and acids are liquids that only become a solid when they bond to create the neutral salt. As the salt form is neutral it carries no net
positive (or negative) charge making it impossible to be too acidic or too basic. The only way an end product salt could be slightly
acidic is through poor quality reagents, such as the metals in consumer grade hardware store hydrochloric acid forming a side product.
This is one of the reasons it’s preferable to do a recrystallization cleaning up the end product."
Here is a comment about citrate though:::::::;
"It is not acidic because there are traces of citric acid.
"Citric acid has 3 organic acid groups -COOH. Mescaline only occupies one of them when making the monomescaline salt.
The two extra acidic groups in solution will end up donanting some H+ lowering the pH. This is coming from the salt itself.
All this can be calculated using the various Pkas of citric acid and mescaline."
Question: With the final mescaline citrate PH from Cielo or another tech being around 6, when drinking the mescaline citrate after the extraction, could you just drink it and simply drink it with some baking soda to make it neutral? Would it be more complex then that?
From the first comment:
"We are discussing the salt chemistry of compounds containing carbon-hydrogen bonds, these alkaloids must be protonated and made neutral
to become a sold salt so it can be extracted and purified, we call this Organic Chemistry. Can salts used for Inorganic Chemistry be acid or base,
yes primarily when their elements are disassociated in water (aq). When people talk about acid or base salts they’re talking about them dissolved into water
AKA: aqueous (aq) solutions Maybe we need to better define what an acid/base is in drug chemistry."
"Looking at HCl and carbonate ions and how they interact in water to makes acids and bases."
'When two atoms or molecules form a union, they are deemed to be “conjugated” In the case of HCl this gas dissolves in water where the Hydrogen (H) and chlorine (Cl)
disassociate, coordinating with water to become hydrochloric acid HCl(aq). This new combination is called a conjugate acid-base pair."
"Yeah, probably paranoia HCl salts are neutral, CO2(aq) a weak acid and the amino group a strong base. I’d be way more concerned about it being too basic as the
crystals turn to mush on standing with exposure to the air."
"As I said before I doubt that would be necessary, if you have it recrystallized, I don’t see how it cold be anything other than neutral."
Question: I didn't put the whole comment, and I was asking other questions too, I know other salts can be positive or neutral, seems mescaline salts are neutral except for citrate even after the wash crystallization?
With the final mescaline citrate PH from Cielo or another tech being around 6, when drinking the mescaline citrate after the extraction, could you just drink it and simply drink it with some baking soda to make it neutral? Would it be more complex then that?
