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Question about amphetamine and its N alkylations.

I recently came up with a theoreical amphetamine.

After roaming on erowid and google I found out that many piperazine derivates act as stimulants (Like BZP wich is said to be as potent as amphetamine) or antipsychotics.
It seems that any piperazine derivate has a psychoactive effect.

Well then...my question is pretty obvious.

How potent could N-piperazine-methylamphetamine be?
Anyone could give me sme info on this substance?
 
The one time I tried phenmetrazine I found it loads more euphoric than meth.

What do you mean by n-piperazine-methylamphetamine? Where does the methyl go there? Do you mean to extend the amine into a piperazine and then add a methyl group there somewhere? That would very likely be a completely inactive substance. Read a bit more chemistry, and you could come up with more plausible ideas for chemicals.
 
How potent could N-piperazine-methylamphetamine be?
Anyone could give me sme info on this substance?
Click to expand...

Well the way you're wording it, the only way that structure could exist would be if it were a hydrazine derivarive (one nitrogen atom directly bonded to the other) and you really dont want to be taking those types of compounds as thay tend to be irreversable enzyme inhibitors (and because of that, in some cases quite hepatotoxic). Phenelzine (phenethylhydrazine, the hydrazine equivalent of phenethylamine) is a clinically used irreverible inhibitor of MAO-A AND NOT SOMETHING TO FUCK AROUND WITH
 
^^ On that note who wants to eat any hydrazine-containing compounds? They've all turned out to be pretty terrible pharmaceuticals.
 
True, the only real use for hydrazine derivatives is as rocket fuel (eg 1,2-dimethylhydrazine), but even then it's hideously toxic - an early accident with it in the Soviet space program killed a fair few technicians & scientist at Baikonur (in Khazakstan)
 
fastandbulbous said:
Well the way you're wording it, the only way that structure could exist would be if it were a hydrazine derivarive (one nitrogen atom directly bonded to the other) and you really dont want to be taking those types of compounds as thay tend to be irreversable enzyme inhibitors (and because of that, in some cases quite hepatotoxic). Phenelzine (phenethylhydrazine, the hydrazine equivalent of phenethylamine) is a clinically used irreverible inhibitor of MAO-A AND NOT SOMETHING TO FUCK AROUND WITH
Click to expand...

My suggestion came by looking at the BZP molecule, later on I found out that many piperazine derivates had a variety of psychoactive effects (stimulant, antipsychotic, sedative, nootropic and even hallucinogen).

I've once been prescribed with olanzapine wich also has a piperazine molecule in its structure, and to be honest I doubt it had any interaction with MAOs.

Have a look:
http://en.wikipedia.org/wiki/Piperazine

Some scientific experiments on amphetamine addicts confirmed that most of the addicts where unable to distinguish an IV dose of BZP from IV dose of d-amphetamine.

I'm incredibly curious about the possible psychoactive effects of N-phenylpropan-2-piperazine. (is the nomenclature correct?)

A little voice in my head tells me that it might kick ass!!=D
 
It just doesn't make sense. If I understand what you're talking about, you're describing 2-benzylpiperazine.

84477-71-4.gif
 
Lol I have little idea what structure you are talking about. So, piperazine ring with a phenyl on one N.. okay, good so far. But the propan-2.. what? Are you perhaps meaning 4-isopropyl-1-phenylpiperazine? If so, I don't see why that would be any good. The phenylpiperazines are not good stimulants (the benzylpiperazines aren't "good" either, but they at least work), and from the SAR of the phenylpiperazines we know that alkylating the second N makes them even less potent.
 
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I think what's meant is 1-phenyl-2-(1-piperazinyl)propane - basically a disubstituted amphetamine (which are generally not too hot on the stimulant stakes).


I've once been prescribed with olanzapine wich also has a piperazine molecule in its structure, and to be honest I doubt it had any interaction with MAOs.
Click to expand...

Just because somehing contains a piperazine ring doesn't mean that all containing that ring will have the same sort of pharmacology, so you can't say all of them will be safe with an MAOI (I certainly wouldn't take BZP with an MAOI)
 
ive tried phendimetrizine, alone, with shots of coke and along with meth, being on 1/3 of a gram of phdmtz made the coke shots much more of a rush physically intense and cerebrally intense as well---i never tried the initial substance mentioned but have tried well over 100-150 rx's alone so i was curious...jester
aka wildbill
 
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