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Question about amphetamine and its N alkylations.

/navarone/

/navarone/

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Under your bed, masturbating...
Good day.

I've been roaming around wikipedia and google to find and answer but i came out empty handed.

Ok so we got (dextro)amphetamine, wich is a pretty strong stimulant,
Then we have the evil looking d-meth wich is, in terms of effects, WAY more potent than dexamphetamine.

So my question is:
How come that ethylamphetamine and dimethylamphetamine are less potent than d-methamphetamine.

Are there any amphetamines that are stronger than meth in terms of effects?
Some guy talked to me about this N-cyclohexane-dextroamphetamine saying it was more potent and less neurotoxic. Is it true?

Last question:
Wich amphetamine derivate is the less neurotoxic?
 
Anything bigger than n-butyl abolishes activity according to the table I pulled from a paper (actually the NIDA monograph if anybody wants to rummage through the 200 odd pages it comprises), so the bit about N-cyclohexyl sounds a bit iffy to me.

Basically if you want the least neurotoxic, stick with amphetamine as all of the N-alkylated derivatives also have some significant degree of serotonogic activity & it's the dopamine/serotonin combo of efflux that causes the neurotoxicity (a la MDMA)
 
Phenmetrazine. It's less potent by weight, but by effects it kicks the ass of methamphetamine.

e. I also believe it to be less neurotoxic than meth, but I'm not sure.
 
dread said:
Phenmetrazine. It's less potent by weight, but by effects it kicks the ass of methamphetamine.

e. I also believe it to be less neurotoxic than meth, but I'm not sure.
Click to expand...


INTERESTING!
For years i've been reserching for an amphetamine more potent than meth.
thanks for the info.

How about Methylenedioxyphenmetrazine? It should kick ass.
 
I would think so, but so far I haven't heard of anyone synthethizing it.
And I wouldn't say phenm. is more "potent" than meth, you have to take larger amounts of it, but the effects are so much better in so many ways.. more euphoric, less jittery, less psychotic.. Although, phenm. is considered more addictive too.
 
How about Methylenedioxyphenmetrazine? It should kick ass.
Click to expand...

What is this obsession with sticking a methylenedioxy group on stimulants. MDMA has some very specific conformational requirements in order to do what it does & most stimulants simply don't fit the model, so a methylenedioxy group isn''t going to give an entactogen
 
^ I guess a lot people really like MDMA and this has led to a sort of methylenedioxy-moiety fetish--people get turned on by those two oxygens and a carbon. It's all just CO2 to me, though.
 
Preludin (Phenmetrizine) turned the Beatles on to R@R in 1960, and was the favourite for abusers and first to be banned in Sweden~1960, followed by Ritalin in 1968.

Preludin sounds like the bomb topping Desoxyn
 
about #9:
Thx for quoting Wiki (without quotation-marks).

And what does your post tell us?
 
Last edited:
MurphyClox said:
Thx for quoting Wiki (without quotation-marks).

And what does your post tell us?
Click to expand...

Your last 10 posts have been telling other people they are posting worthless stuff, or don't know what they're talking about. Just thought I'd bring that to your attention before you questions others' posts :)
 
djsim said:
Your last 10 posts have been telling other people they are posting worthless stuff, or don't know what they're talking about. Just thought I'd bring that to your attention before you questions others' posts :)
Click to expand...
Interesting that somebody is tracing my steps...

Edit: And learn counting! It were only the last 4 posts (this one not included). ;)
 
Last edited:
/navarone/ : If you'd read far enough, you'd see that http://en.wikipedia.org/wiki/Phendimetrazine is the N-methylated version of Phenmetrazine. It is much weaker, and most probably only generates activity through it's hepatic demethylation to phenmetrazine.

I can understand Murphy's irritation sometimes.
 
tertiary amines in these are not good for activity, well known, I would have thought.
 
After some research i found that N-methylphenmerazine is weaker as a stimulant than phemetrazine, however about 30% of the drug is metabolized into phenmetrazine short after research.

N-methylphenmetrazine is currently used as an obesity medication in the U.S. under the name Bontril.

Did anyone here ever tried phenmetrazine? What are the differences in terms of effects compared to methamphetamine?
 
Although I haven't tried phenmetrazine, I found phendimetrazine to be a pretty shitty drug.

Aminorex sounds like a good drug; while it is less potent than meth, it has a favorable NE:DA ratio, and is a bit more serotonergic (but of course, so is fenfluramine). Also, the side-effects are less pronounced, or at least I found this to be the case with 4-methylaminorex.

What is this obsession with sticking a methylenedioxy group on stimulants.
Click to expand...
This does seem to be a common occurrence....
 
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