Pynazolam

[pcplease]

I long assumed the claim this chem was a bluff, as a much more reputable/veteran released fluoprazolam on the release date claimed for this chem, but is now available from the most reputable CN sources.

Will be a while for me, and while I do still intend to send to Kykeon but have high hopes considering the source. I thought their claim of producing it was simple obfuscation while working on an unforeseen/novelty (loprazolam derivative fluoprazolam).


I hope eventually will offer pyrazolam itself for its therapeutic potential (and demand). In any case, pleasant unexpected surprise after writing the chance to ever try this chem off weeks ago.

 

[pcplease]

As expected, reports are all over the place on this one, with added bonus of yellow, orange, dirt brown powder from various sources.

1-2mg is extremely sedating to me in the morning. I am tolerant to benzos, and have my best attempt at constant level of 3-oh-phenazepam in my system.
Not much, enough to go to the hospital for 8 days with no tremor so could apparently jump off whenever. 1mg of this and fluoprazolam were very strong.


It seems self-limiting and past a limit redosing seemed trivial. That is good, re: bzd's. Fluop on the other hand, is one I foresee many people waking up with the bottle missing.

 

[gabacool]

Thanks for creating the thread and your report. Did you ever confirm it via Kykeon?

 

[notsmokeymcpot42088]

I missed so much good info cuz I was reading in pyRazolam and though eh who cares not my flavor...

Phenaz was the only benzo that ever messed me up too (I presume 3-oh-phenaz to be similar) Didn't end up in a hospital but I did completely forget I had an entire gram of dope -- get sick and start calling around till I got to the guy who hooked me up like 3 hours earlier.... "My guy I was just visiting you" --- "Bullshit man I gotta see you" --- "Alright but before I swing through do me a favor and check your top left drawer" --- " Uhhh Come by not tomorrow but the next day ish" lol

 

[pcplease]

Thanks for creating the thread and your report. Did you ever confirm it via Kykeon?

Very different than Pyrazolam and every traditional benzo available now. Fluop is unique in a different way.

. Someone else with the clean bright powder will before then will have to. Late next month they say. and I am not sending in the dirt brown crap. This is very unique and many don't like it as a benzo. This is sedating at a mg or 2, 5-10mg strong unique buzz.

3-OH-Phenazepam is very valuable to me, and and Phenazolam may be the most recreational benzo for me.


, I don't know if this Pynazolam would potentiate CNS depressants as much or more as other benzos. Take care of yourself

 

[notsmokeymcpot42088]

Phenazolam is the next one I am looking at --- as it seems to very much meet the qualifications I usually find enjoyable to research

pyNazolam I have never heard of existing on the market and kind of doubt I ever do -- pyrazolam was nothing special.

 

[jupitersstorm]

Have a somewhat decent tolerance (not too high, mostly just from script and occasional rc use.)

(Note: any doses taken, were done on seperate occasions so I could really gauge how it felt with nothing overlapping.)

2mg for me was when I really noticed it, but when I got to 4mg it was relaxing, warm and euphoric. Not extremely sedating personally, it was a mix of sedation and your body feeling light, mood increase.

(caution; could be considered high dose for this compound as it’s new and tolerances very.) 10mg was for sure noticeable/powerful for me. I was quite impaired. The euphoria and warmth was all encompassing, blissful. But motor skills became very impaired, especially walking. I could do things (not very well), but I for sure could not operate machinery nor go in public.
I didn’t go past that dose for clear reasons.


Some thoughts:
It has a rapid onset, atleast 30min about people say, which holds pretty true because it kicks in fast.
Once you hit your right dose: you feel quite light, relaxed, and euphoric, slight sedation. The duration isn’t too long (sorry I didn’t get a good time for it.)

In the highest doses I tried, it was very noticeable. The feeling becomes all encompassing. Feeling warm and light, head to toe. My motor skills were for sure impaired. Able to do things still, but defenitely not operate any machinery or be in public lol.
In my opinion, Pynazolam is not like “the next whatever” people will always hype about online when something new comes out. But overall it’s a decent recreational benzo in my opinion. I’m not quite sure the therapeutic value you could get out of this. In my opinion, it has some redose/binge potential due of the euphoria/warm/light feeling at certain doses.

 

[notsmokeymcpot42088]

Right --- nvm it is a triazolo -- musta been thinking of something else ???

Did you try clonazolam, flubromazolam? Comparison in euphoria

lol apparently there is a slim chance of me running across it!

 

[pcplease]

Have a somewhat decent tolerance (not too high, mostly just from script and occasional rc use.)

(Note: any doses taken, were done on seperate occasions so I could really gauge how it felt with nothing overlapping.)

2mg for me was when I really noticed it, but when I got to 4mg it was relaxing, warm and euphoric. Not extremely sedating personally, it was a mix of sedation and your body feeling light, mood increase.

(caution; could be considered high dose for this compound as it’s new and tolerances very.) 10mg was for sure noticeable/powerful for me. I was quite impaired. The euphoria and warmth was all encompassing, blissful. But motor skills became very impaired, especially walking. I could do things (not very well), but I for sure could not operate machinery nor go in public.
I didn’t go past that dose for clear reasons.


Some thoughts:
It has a rapid onset, atleast 30min about people say, which holds pretty true because it kicks in fast.
Once you hit your right dose: you feel quite light, relaxed, and euphoric, slight sedation. The duration isn’t too long (sorry I didn’t get a good time for it.)

In the highest doses I tried, it was very noticeable. The feeling becomes all encompassing. Feeling warm and light, head to toe. My motor skills were for sure impaired. Able to do things still, but defenitely not operate any machinery or be in public lol.
In my opinion, Pynazolam is not like “the next whatever” people will always hype about online when something new comes out. But overall it’s a decent recreational benzo in my opinion. I’m not quite sure the therapeutic value you could get out of this. In my opinion, it has some redose/binge potential due of the euphoria/warm/light feeling at certain doses.

if it has a very short half life, much less physical dependency due to its unique binding/blocking effect, and is excreted unchanged, it might be extremely therapeutic for some in the mornings or nights.

 

[pcplease]

Right --- nvm it is a triazolo -- musta been thinking of something else ???

Did you try clonazolam, flubromazolam? Comparison in euphoria

lol apparently there is a slim chance of me running across it!

it has a pyridine like bromazepam and pyrazolam, and a 7-nitro instead of the bromine.

They are total opposites. Pynazolam no a1 activity at all, which cLam and flublam "Lam's" in general have incredibly high affinity for.

 

[notsmokeymcpot42088]

Total opposites -- damn I wish I understood chemistry better.

a1 is most associated with - Euphoria? Sedation? Hypnotic? Ant-anxiety? (I forgot the word shutup lol)

I guess 'opposites how effect wise' is the best words I have available (Which isn't great) but I think it gets the question across (?)

 

[pcplease]

a1 is amnesia, delusions of sobriety, hypnotic effects
a5 = loss of executive function i.e. blackout. Amplification of other bzd effects. The one site ethanol also has some affect at
All these novel "Lam" triazoles particularly affect a1 and a5

 

[4DQSAR]

a1 is amnesia, delusions of sobriety, hypnotic effects
a5 = loss of executive function i.e. blackout. Amplification of other bzd effects. The one site ethanol also has some affect at
All these novel "Lam" triazoles particularly affect a1 and a5

That's pretty much why pyrazolam was designed to be fairly selective to the a3/a4 subunits.

An anxiolytic without the side-effects. It was never intended to be 'fun', it was intended to help people who suffer severe anxiety.

 

[pcplease]

It may not feel anxiolytic for some, but 1mg in the morning has brought very smooth mornings (~3hrs) lately. I enjoy a couple mg in the evening. No craving through the day until the evening or anything, just not conducive to work.

 

[Slightly_Paranoid13]

"An anxiolytic without the side-effects. It was never intended to be 'fun', it was intended to help people who suffer severe anxiety."
^This exactly. I've been an anxiety sufferer since I was 12. The shit gets old after while and eventually you'll take anything that helps at all. I used to be one of them, but really dislike how the kids are abusing benzo's, thus making it harder and harder for the legit anxiety sufferers to get adequate relief. Most young doctors are straight up scared to prescribe them, while the old school docs are retiring. I am grateful for my small benzo PRN Rx and for some legit RC's like Pyn@zolam. Seems like a new and improved Pyr@zolam. Both go unchanged in the body. The pyr@zolam I currently have is bunk (either that or it's just a shitty benzo but I think I got a bad batch tbh). Took some during a panic attack and was underwhelmed. Got some Pyn@zolam otw and will post my experience with it here.

 

[4DQSAR]

Pyrazolam is the better anxiolytic by which I mean you don't really feel sedated, just less anxious.

I've explained to others but both pynazolam and pyeyezolam were synthesized to confirm receptor calculations. Pynazolam is a serotonin releaser so is far more euphoric (we found 5-10mg to be optimal) and shorter acting. Pyeyzolam, as the name hints, is the alcohol mimic... the one we sold to Nutt ;-) We could NOT see a pathway for an alcohol mimic to reach the market and when we had a meeting with Nutt, we suggested two routes, both of which were discounted due to time and cost issues (although it WAS admitted they would likely work). So when asked if we wanted cash or shares... we took the cash INSTANTLY. No discussion - we ALL said 'cash' instantly. A decade later and Nutt has put his name on a herbal alcohol mimic that is NOT selling very well and he's more or less admitted that there is no pathway for a SYNTHETIC alcohol mimic to reach market.

But don't take me as someone who hates Nutt. The company has been renamed GABA Labs and venture capitalists are paying MILLIONS for shares of some future profit so I begin to think Nutt already knew there was no economic (our routes needed £billions) pathway to market BUT his name alone is WORTH millions. So a con - but he isn't MAKING people invest. I can only assume none of these venture capitalists have asked what we thought was the KEY question as alcohol mimics are not as hard to design as people may think. We made several and I assure you, we are NOT smart.

The second-generation alcohol mimic solved the issue that pyeyzolam could emulate 'drunk' but not a glass of wine i.e. it was all or nothing. It turns out that one needs to bind to THREE specific receptor subtypes and designing a single compound that would hit all three in the appropriate ratios was an order of magnitude more tricky until a bit of sideways logic solved it. But then UK law changed so all research was halted. Sad, since it really was nigh on identical in the POSITIVE effects of alcohol with none of the negatives. But still, an enjoyable bit of research.

 

[Slightly_Paranoid13]

Omg, that insider information is so cool! This stuff is right up my alley because I have struggled with crippling anxiety since 12. Just to go outside the house, I would get increased heart rate and a paranoid hyper vigilance that I could not shake. Socializing has always been the most exhausting thing for me. Therefore, I've always had a love/hate relationship with benzos. Beer was the first chemical I ever used and immediately realized that my anxiety was gone after 2 or 3 drinks. So much, I would sing vanilla ice in front of my friends lol.
I am shocked that I never became an alcoholic, but I have been hooked on benzos and opiates. I didn't realize it at the time, but I myself, was looking for an alcohol mimic that didn't come with the side effects (or negative consequences) of alcohol. As you know, alcohol hits many different receptors in the brain, so I am not surprised that you had trouble during that project. I think alcohol is underwhelming when it comes to pharmacology. For me, it leaves me jonesing for other substances. It lowers my inhibitions too much and end up jonesing for other drugs that are not good for me. So, I find it easier to avoid altogether. Plus, I am on medications and alcohol definitely has a negative interaction with them.
I use cannabis instead, but even that comes with some baggage. I've recently heard people talk about their lives while using cannabis and while not using it and most people (if they are being honest) seem to do better without it. Now, I know it can be medicinal for some and that is great if something natural and safe mitigates your symptoms. However, nothing these days is one size fits all. You got to find what works for you specifically. It will take some trial and error, but you'll get to a state of contentment eventually. I am working on getting healthier habits and have found the more I lean into them, the more I end up liking them as time goes on. For example, I used to hate going on walks, but now that I've been forcing myself to exercise more often, I've come to enjoy the little things and benefits from doing so.

 

[4DQSAR]

Be aware that we did not have the resources to carry out a proper stage 3 trial. I know it's remiss but one of the design criterion was that pyrazolam NOT be metabolized but instead excreted unchanged. The reason was simply the fact that genetic diversity could result in multiple metabolic pathways and so not acting in the same way or worse still, a toxic metabolite forming. So work went in to what we termed 'defensive design'. If metabolism is unavoidable, include a labile moiety so at least there will only be ONE metabolic pathway.

But to be clear, while not demonstrating much of a dependence liability, addiction is a totally different beast. Absence of evidence isn't evidence of absence.