Purdue receives FDA approval for bupe patch

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PURDUE PHARMA L.P. RECEIVES FDA APPROVAL FOR BUTRANS™ (buprenorphine) TRANSDERMAL SYSTEM CIII
Purude Pharma
7.1.10


Stamford, CT – July 1st, 2010 – Purdue Pharma L.P. announced today that the U.S. Food and Drug Administration (FDA) approved Butrans™ (buprenorphine) Transdermal System CIII for the management of moderate to severe chronic pain in patients requiring a continuous, around-the-clock opioid analgesic for an extended period of time. Butrans Transdermal System is an analgesic product that delivers continuous release of medication for seven days. Purdue expects to launch Butrans commercially in the U.S. early in 2011.

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Link!
 
Purdue's way of saying "we got you" to all the people that started their opiate addiction with OxyContin.
 
phrozen said:
Purdue's way of saying "we got you" to all the people that started their opiate addiction with OxyContin.
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yeah dude it really makes ya wonder... cuz we all know that 99.9% of opiate addicts started with OxyContin... and now this, but I thought Bupe was no good for pain and only good for detoxing/maintaining ???
 
Bupe will work well for pain but only if you are opiate naive. Once you're tolerance is high enough it wont do shit, and then you will run into the issue of forcing legitimate chronic pain patients to go through withdrawals on top of dealing with they're pain while they wait for the sub to get out of their systems before switching to something stronger.
 
Sounds ideal as an anti-depressant due to its reliable sustained-release qualities. Not that it will be prescribed for this (though technically it can be as it is S.III).
 
caseface99 said:
Bupe will work well for pain but only if you are opiate naive. Once you're tolerance is high enough it wont do shit, and then you will run into the issue of forcing legitimate chronic pain patients to go through withdrawals on top of dealing with they're pain while they wait for the sub to get out of their systems before switching to something stronger.
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i disagree. i'm certainly not opiate naive, received great pain control from buprenorphine and have used buprenorphine patches in the past for Pain Management with success. i think they've even got a place in ORT programs. you can check my gallery for pictures of the patches we have access to here in australia

the transdermal systems on these patches only let out micrograms per hour and other breakthrough opiates can be used on top without any problems.
 
Buprenorphine Transdermal System (Butrans™) – Receives FDA Approval

Buprenorphine Transdermal System (Butrans™) – Receives FDA Approval

The FDA and Purdue Pharma, the maker of Butrans, announced a July 2010 approval of a transdermal system for the management of moderate to severe chronic pain in patients requiring continuous opioid analgesia. This unique formulation of buprenorphine — preceded by the parenteral form approved in 1981 — acts as a partial agonist at mu-opioid receptors and as an antagonist at kappa receptors. Each Butrans transdermal patch delivers continuous-release analgesia for 7 days; patches are available in 5, 10, and 20 mcg/hour strengths. Four 12-week double-blind, controlled clinical trials in both opioid-naïve and opioid-experienced patients with moderate to severe chronic low back pain or osteoarthritis helped to demonstrate Butrans’ efficacy for pain reduction. The most common adverse effects were gastrointestinal disturbances, various application-site irritations, headache, dizziness, somnolence, and dry mouth. Clinicians should visit http://www.butrans.com/ to read the Prescribing Information and Medication Guide for further details, including contraindications and precautions.

http://updates.pain-topics.org/2010/08/aug2010-pain-product-announcements.html
 
Sounds nice but I imagine it must be super fucking expensive too. When I was prescribed the 8/2mg sublingual tablets, with no insurance it cost $237.99 for a 2 week supply. But I would cut this in half and make it last 30 days simply because I could not afford it. Sucks to be uninsured...
 
Yea it will be fuckin well expensive until they become generic. They work fantastically for pain though :)
A good friend of mine uses a 0.5mg/hr patch and it works extremely well she says. She used to use Morphine ER and it way surpasses the analgesic ability of that.
 
villian said:
Four 12-week double-blind, controlled clinical trials in both opioid-naïve and opioid-experienced patients with moderate to severe chronic low back pain or osteoarthritis helped to demonstrate Butrans’ efficacy for pain reduction. The most common adverse effects were gastrointestinal disturbances, various application-site irritations, headache, dizziness, somnolence, and dry mouth. Clinicians should visit http://www.butrans.com/ to read the Prescribing Information and Medication Guide for further details, including contraindications and precautions.

http://updates.pain-topics.org/2010/08/aug2010-pain-product-announcements.html
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i think buprenorphine is a great painkiller (i fit the research category fwiw) but overall through the transdermal system it really failed me. i was suffering chronic headaches throughout the period wearing them, my mouth was constantly dry (much less so than pills, fent transderm left me dry as well) and in the end i started having allergic reactions to the silicone in the adhesive.
 
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