Psychedelics while depressed?

[amazing]

25i-nbome to be exact.

I'm just wondering if this is a bad idea, will it just enhance my depression and give me a awful trip?
or is there still a chance i'l have a really good trip that will help me overcome my depression? or at least make me not depressed while the drug is effecting me?

 

[.22]

i ate a small amount of mushrooms one night when i started sleeping outside , helped make me look at it as an adventure instead of being depressed about it

 

[Mysterie]

just dont have a high dose, its not going to help you overcome your depression, and you will probably be depressed during the trip but it could distract you from it i guess

 

[a3m]

A small dose might help your depression as it's a 5HT agonist.

But be in a comfortable place. 25i isn't very mental/spiritual... and it can be very physically unpleasant. Drink lots of water and try to move around to keep the vasoconstriction in check. A lot of people get anxiety during the come-up but after that you should be fine. Take a dose of 400mcg or so if you can.

 

[MagickalKat777]

I can't see how 25I would be good at all during times of depression.

The only psychedelic I can think of that wouldn't be a bad idea is AMT and that's because it has no crash and its an immediately-functional antidepressant.

 

[Foreigner]

It depends.

If your depression is purely biochemical then I wouldn't do it.

If it's because of some kind of mental or emotional block that you need more insight into, it could help.

If you can't tell the difference between the two, I wouldn't do it.

 

[ZFC]

It works remarkably well, but the secret is small dose! Normal or large doses could be counte-productive.

 

[any major dude]

It's kind of a crapshoot. Might help you shake off a depression, or at least gain some insight into why you're feeling that way. It might make you dwell on the depression & feel worse. Or it just might be a mild distraction from the depression for a few hrs leaving you more or less where you started. Impossible to say really. Tread carefully

 

[plusfourpirate]

I agree w any major dude. My response to you was going to be tread carefully, actually.heh.

I went through a major funk a couple of years ago, during which I decided to trip w some close friends to hopefully lift my spirits. I took some 4homet with a close.friend, and had a great time. Really helped to lift my spirits and show me my problems leading up.to it all. but in the same respect, I knew I had a long way to go.

Now, about a month later, I was starting to feel better and gain some of my motivation back, I decided to trip again w the same cllse friend, with the same intent as the last time and further explore my issues a little deeper. Set and setting were practically identical, only this time we each ate 2hits of some really good L I had been saving for a rainy day. This time I had a very diffcult trip;highly emotional and very unpleasant. I uncovered a lot more from within at an exponentail rate in contrast to the metocin trip the month prior, and tbh it was far too muchto take in at once.

I didn't realize until it was too late that my state of mind was still too fragile for such a large dose of the brutal truth. It caused me a lot of anxiety, and triggered some significant feelings of panic. Almost like it amplified my response to my problems, and set me back by making me face everything at once, when I should have respected my state of mind more, and worked through things more slowly.

My advice is if you want to trip to lighten your mood and face some internal struggles, that you maybe try something a little easier on the mind. I've never done 25i as I'm put back by how I've seen friends react to it, but I imagine and gather it is similar to L, where as metocin is very gentle or forgiving. Maybe try something a little more gentle first to guage where exactly your mind is at before jumping into an intense trip and doing yourself more harm than good. This is just based on my personal expeience tho and we are all different so take it fwiw.as always ymmv.

Hope you find the answers you are looking for bro, and just remember that saying 'this too shall pass' . It ll get better bro, it a,ways does. Just have a little faith and remember to keep moving.
---Love n light to ya---

 

[krrl]

I can't see how 25I would be good at all during times of depression.

The only psychedelic I can think of that wouldn't be a bad idea is AMT and that's because it has no crash and its an immediately-functional antidepressant.

Can you please explain that a bit further? I'm curious to know more.

As for the thread topic, I also think it can depend on plenty of factors, especially set & setting but yeah, the type of depression too. I'm more inclined to say you're better without it, but then, this is my personal feeling & related to what I would do.

 

[ZFC]

Can you please explain that a bit further? I'm curious to know more.

As for the thread topic, I also think it can depend on plenty of factors, especially set & setting but yeah, the type of depression too. I'm more inclined to say you're better without it, but then, this is my personal feeling & related to what I would do.

I think MagickalKat777 is referring to the fact that AMT seems to be a mild MAOI. But the interesting anti-depressive properties of psychedelics have little to do with mono-amine oxidase inhibition.

I wouldn't choose 25i either, though, but whatever OP chooses, I recommend no more than something that would provide a +1 experience, maybe even micro-dosing (in micro-dosing you should be able to carry on with your day without noticing much that you are tripping), and at the end of the day I am confident that you will positively evaluate the overall quality of your mental state throughout the day compared to days without pharmacological help. Once your mindset is back up and stable, you can offer yourself a full normal or strong psychedelic experience.

 

[MagickalKat777]

Can you please explain that a bit further? I'm curious to know more.

As for the thread topic, I also think it can depend on plenty of factors, especially set & setting but yeah, the type of depression too. I'm more inclined to say you're better without it, but then, this is my personal feeling & related to what I would do.

I think MagickalKat777 is referring to the fact that AMT seems to be a mild MAOI. But the interesting anti-depressive properties of psychedelics have little to do with mono-amine oxidase inhibition.

Actually, I am referring to the fact that aMT is both a triple reuptake inhibitor and also a triple monoamine releaser at the same time. In a decent dose, these effects come together and effectively turn aMT into an antidepressant that kicks in as soon as it begins to take effect (the "speedy" part before the plateau).

Its activity on MAO is not that great, its about equi-potent to harmala alkaloids which have doses greater than 100mg (I've heard 200mg but I could be wrong on that) - the big problem with aMT combinations is its dual mode of action, simultaneously releasing all three primary monoamines (serotinin, dopamine, and norepinephrine) while blocking their reuptake as well but this is what is largely responsible for its effectiveness as an antidepressant. Its serotonin agonism obviously accounts for its psychedelia although its similarity in structure to serotonin in the first place probably fits in there somewhere like a,O-dimethylserotonin aka 5-MeO-aMT.

Indopan was a very effective anti-depressant used in the USSR - along with the tricyclics, it was one of the few antidepressants to actually be markedly better than placebo and it was only used in 5mg and 10mg doses to achieve the effects.

EDIT: "α-Metyltryptamine (AMT), a tryptamine derivative, was one of the strongest re-uptake inhibitors and releasers of the three monoamines. The tryptamine derivative, 5-methoxy-α-methyltryptamine (5-MeO-AMT), also strongly inhibited re-uptake and increased the release of the three monoamines."

Source: http://www.sciencedirect.com/science/article/pii/S0014299906013811

I had a whole shitload of documents on aMT but I believe those are long gone now as they were on an old hard drive. I'll have to look.

Either way, the best anti-depressant that has ever hit the market was pulled because of abuse potential. Unlike aET, aMT never had a single case of agranulocytosis associated with it and was withdrawn purely on the abuse basis. Not only that, it was and still is the fastest-acting anti-depressant with an average time of 5 days to complete depression reversal at the 10mg dose.

 

[ZFC]

Actually, I am referring to the fact that aMT is both a triple reuptake inhibitor and also a triple monoamine releaser at the same time. In a decent dose, these effects come together and effectively turn aMT into an antidepressant that kicks in as soon as it begins to take effect (the "speedy" part before the plateau).

Its activity on MAO is not that great, its about equi-potent to harmala alkaloids which have doses greater than 100mg (I've heard 200mg but I could be wrong on that) - the big problem with aMT combinations is its dual mode of action, simultaneously releasing all three primary monoamines (serotinin, dopamine, and norepinephrine) while blocking their reuptake as well but this is what is largely responsible for its effectiveness as an antidepressant. Its serotonin agonism obviously accounts for its psychedelia although its similarity in structure to serotonin in the first place probably fits in there somewhere like a,O-dimethylserotonin aka 5-MeO-aMT.

Indopan was a very effective anti-depressant used in the USSR - along with the tricyclics, it was one of the few antidepressants to actually be markedly better than placebo and it was only used in 5mg and 10mg doses to achieve the effects.

EDIT: "α-Metyltryptamine (AMT), a tryptamine derivative, was one of the strongest re-uptake inhibitors and releasers of the three monoamines. The tryptamine derivative, 5-methoxy-α-methyltryptamine (5-MeO-AMT), also strongly inhibited re-uptake and increased the release of the three monoamines."

Source: http://www.sciencedirect.com/science/article/pii/S0014299906013811

I had a whole shitload of documents on aMT but I believe those are long gone now as they were on an old hard drive. I'll have to look.

Either way, the best anti-depressant that has ever hit the market was pulled because of abuse potential. Unlike aET, aMT never had a single case of agranulocytosis associated with it and was withdrawn purely on the abuse basis. Not only that, it was and still is the fastest-acting anti-depressant with an average time of 5 days to complete depression reversal at the 10mg dose.

Thanks for that information. If you ever find your sources, don't hesitate to post them here (or in the aMT thread, if that isn't already done).
I'm interested in knowing more about the ban on the abuse basis. Why aMT and not valium, codeine, etc. Well, we all kind of know *why* but how was it justified at the time?

 

[krrl]

Actually, I am referring to the fact that aMT is both a triple reuptake inhibitor and also a triple monoamine releaser at the same time. In a decent dose, these effects come together and effectively turn aMT into an antidepressant that kicks in as soon as it begins to take effect (the "speedy" part before the plateau).

Its activity on MAO is not that great, its about equi-potent to harmala alkaloids which have doses greater than 100mg (I've heard 200mg but I could be wrong on that) - the big problem with aMT combinations is its dual mode of action, simultaneously releasing all three primary monoamines (serotinin, dopamine, and norepinephrine) while blocking their reuptake as well but this is what is largely responsible for its effectiveness as an antidepressant. Its serotonin agonism obviously accounts for its psychedelia although its similarity in structure to serotonin in the first place probably fits in there somewhere like a,O-dimethylserotonin aka 5-MeO-aMT.

Indopan was a very effective anti-depressant used in the USSR - along with the tricyclics, it was one of the few antidepressants to actually be markedly better than placebo and it was only used in 5mg and 10mg doses to achieve the effects.

EDIT: "α-Metyltryptamine (AMT), a tryptamine derivative, was one of the strongest re-uptake inhibitors and releasers of the three monoamines. The tryptamine derivative, 5-methoxy-α-methyltryptamine (5-MeO-AMT), also strongly inhibited re-uptake and increased the release of the three monoamines."

Source: http://www.sciencedirect.com/science/article/pii/S0014299906013811

I had a whole shitload of documents on aMT but I believe those are long gone now as they were on an old hard drive. I'll have to look.

Either way, the best anti-depressant that has ever hit the market was pulled because of abuse potential. Unlike aET, aMT never had a single case of agranulocytosis associated with it and was withdrawn purely on the abuse basis. Not only that, it was and still is the fastest-acting anti-depressant with an average time of 5 days to complete depression reversal at the 10mg dose.

Thank you for the reply, highly appreciated. Will be re-reading it during my flight today to make sure I understand the details.

 

[ComfortablyNumb95]

well, it could make you reflect upon your worries and make you realize how trivial they are (IF they are)
OR you could get stuck in a depression loop and that would be much worse