They can help in the sense that you're directly fucking with your sense of self when you take them. I had atypical depersonalization before I started taking acid every week a while back. For the majority of the first year it was very very strange, almost as if nothing in this world was familiar to me at all, but I kept calm about it and was able to appreciate it as a new and interesting outlook on life. Since I had experience with this state before, I didn't let it intimidate me. about 8 months later it went away, presumably while tripping but I can't pinpoint an exact moment. Like others have said, it's not exactly the safest thing to do, you can agitate your mind and make yourself infinitely worse by accident. It would be a great idea assuming you can find a therapist trained in psychedelic therapy. Alone, you have a serious chance of worsening your symptoms to an unknown extent.