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Tryptamines Psilocybin has no tolerance?

chris_p said:
I believe psychedelics are self-regulating and 'doing too much or too often' will end up in a lesson to remember and not necessarily any real serious consequences, the one week between is just general advice. Shroom binges changed my perspective on life, I had some real wild experiences and felt rejuvenated for a really long time afterwards, however spacing the trips by a week would've likely gotten me the same benefit either way. Know yourself is what I'd say and don't be scared to experience the moment...
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heh, for me the biggest problem with psychedelic binges is that the tolerance buildup makes them very expensive 😅😅
 
I've experienced something similar to this lack of psilocin tolerance. When i was cultivating fungi, I'd often trip 5-7/7 days a week for up to a month at a time, but I was also eating fungi by the unmeasured handful. If my dehydrator was full at the time, I'd often just harvest a monotub and eat every single fresh mushroom right there without even weighing them. LSD created only a very slight tolerance to psilocin over this period, and ayahuasca amplified psilocin dramatically. This was before I had access to psilacetin (which is what's typically used in mushroom chocolates), so I'll just be speaking on the use of fungi here.

Others around me who used psilocin every other day found insane tolerance build-up, whereas I was using daily and found almost none. What ended up happening though was that psilocin's effects became much less profound feeling and it became more like a psychedelic stimulant, reminding me nowadays (with more diverse RC experience) of things like 2C-B, or a brief take on DOB/DOC if that makes sense. I was compulsively jacking off a ton, I would be up for days straight hacking/coding and working out like an absolute maniac. It also led to me becoming way more prone to violence, whereas normally walking past a homeless guy who calls me a faggot I'd just spit on him or stomp on him a bit, during this phase I was somewhat routinely engaging in long and somewhat tortuous fights (might be closer to assault tbh as I never lost in these situations) when people would say shit that set me off. I was living in a city with an enormous population of mentally ill homeless people at that time, and a ton of violence in my area.

The kind of "I got home late because I was sprinting after a homeless man (who I very likely just hallucinated calling me a name threatening me) with my knife out, intending on gutting him like a fish" events in my life almost exclusively occurred in this "mushroom gremlin" phase of my life. this phase occurred because I was growing mushrooms, often pulling ounces at a time per tub, but I didn't sell a single drug and despite my roommates often eating ~1-2 ounces per week, it was still nothing in comparison to the amount I was consuming. Psilocin, DOx compounds, methamphetamine and ephedrine are the only drugs I've ever used that turn me into an absolute fucking menace in combat situations.

@chris_p I've found psychedelic use not to have any downsides when in binges for some people, but it does for others, and I've rarely found any commonalities between the demographics that benefit from it or not.
 
Ismene2 said:
No they're not.
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I've often looked for evidence that psilacetin is not metabolized in at least as much time as the come-up is, have you ever come across any? It should theoretically take minutes for the dose to hit and it does so via metabolism where it degrades into psilocin. I'd be interested to see what happens even just with mildly aggressive conditions and 4-substituted tryptamines, alongside something like pepsin or similar.
 
I've heard that psilocin has been found in blood samples taken from people after consuming 4-aco-dmt so from that it's fair to assume it is a prodrug, but does that categorically mean that 4-aco-dmt is not capable of crossing the BBB prior to conversion to psilocin? Couldnt it be psychoactive on its own terms while still being a prodrug for psilocin?

I remember Xorkoth always seemed to think so and it makes a lot of sense to me given the rate of onset and differences reported but I know it's hard to determine these things from subjective experience alone.
 
Shinji Ikari said:
I've heard that psilocin has been found in blood samples taken from people after consuming 4-aco-dmt so from that it's fair to assume it is a prodrug, but does that categorically mean that 4-aco-dmt is not capable of crossing the BBB prior to conversion to psilocin? Couldnt it be psychoactive on its own terms while still being a prodrug for psilocin?

I remember Xorkoth always seemed to think so and it makes a lot of sense to me given the rate of onset and differences reported but I know it's hard to determine these things from subjective experience alone.
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The metabolic processes that convert 4-AcO-DMT to 4-HO-DMT shouldn't take longer than a few minutes, aka less than the usual come-up time. So yeah, maybe 4-AcO-DMT is its own drug for less time than it takes for a frozen pizza to cook, sure? Doesn't really seem meaningful to me though.
 
if you dose shrooms half the time it All Costs only a little more than half. only the acid etc. Will be expensive. Best not to do binges i think. I think wait Till the receptors have been replenished. maybe, maybe only, for money
 
youarethebest said:
if you dose shrooms half the time it All Costs only a little more than half. only the acid etc. Will be expensive. Best not to do binges i think. I think wait Till the receptors have been replenished. maybe, maybe only, for money
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Yeah, I sometimes found binges of LSD to be best done with 4-ish day intervals, to fight enough of the tolerance.

Mushrooms and mescaline both bring up really medical feelings, and with the tolerance as it tends to work for me, I can use mushrooms twice a week easily. I could do mescaline one week a week, mushrooms twice in a week, LSD once a week, and something else on the other week. I tend to consider 6 weeks a good break between rolls if I'm dosing low (otherwise I go for 8 weeks), and I want to space seriously dosed disso use (outside of an occasional whippet tank while tripping), and using a different psychedelic on the fourth week, then trip weekly, or biweekly depending on tolerances, like how mushrooms' tolerance last 3-4 days.

Mixing the empathogen and/or dissociative use alongside the trip is probably how I'd do it. When I schedule trips, I tend to do it this way. I should get back in the habit of scheduling trips, tbh.
 
Esperighanto said:
The metabolic processes that convert 4-AcO-DMT to 4-HO-DMT shouldn't take longer than a few minutes, aka less than the usual come-up time. So yeah, maybe 4-AcO-DMT is its own drug for less time than it takes for a frozen pizza to cook, sure? Doesn't really seem meaningful to me though.
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I think Hamilton Morris tried replicating the acidic milieu of a stomach and measuring the conversion. I don't remember what came out of it though. And I don't know where and when he talked about it exactly. Weren't there people wjo reported some kind of biphasic trip with injected 4-AcO-DMT? Could be suggestion too though.
 
xdrc said:
I think Hamilton Morris tried replicating the acidic milieu of a stomach and measuring the conversion. I don't remember what came out of it though. And I don't know where and when he talked about it exactly. Weren't there people wjo reported some kind of biphasic trip with injected 4-AcO-DMT? Could be suggestion too though.
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It's certainly possible, I have highly biphasic trips from mushrooms as somebody with a stomach, ileus, ileostomy, and nothing more.
 
I never knew magic mushrooms had a tolerance. When we were kids, they grew in all the open fields, we just picked them and made tea or hot chocolate. As time passed, we just thought they became less trippy. Those were the days, lying in the sun with my mates, all of us tripping having a good smoke
 
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