Psilocybin and LSD

[Stan the man]

Two nights ago I ate a quarter ounce of mushrooms and tripped pretty hard. Last night I took two hits of acid and felt absolutely nothing. I know your body will build a pretty high tolerance to psychedelics fairly quick but do they have like a "cross-tolerance?" In other words, did the psilocybin also build a tolerance to LSD?

 

[Aetherius Rimor]

From everything I've read, yes.

I always space out trips at least 3 to 4 days apart for that reason.

Never experienced the tolerance effects though, but I've only done more than 4 grams twice (and only 6 at that), and would usually wait awhile before tripping again.

 

[Pjkt2501]

Yes, there is a cross-tolerance. I would keep my adventures to weekends when I was using mushrooms as well. With LSD I'll just dose a bit higher (if I want to trip again during the 4-5day cool-down period) as I find it a more predictable compound than psilocibin can be.