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Psilocin vs Psilocybin

B

busted bones

Bluelighter
Joined
May 19, 2009
Messages
97
I couldnt find anything in the shrooms thread so I was curious if they have different effects psychologically and physiologically? Ive had a decent amount of 2 different batches of shrooms for multiple trips off of each at varying amounts. I was curious though, both batch feel distinctly different.

Batch A has huge body load making it difficult to move with lots of fratual geometric patterns that tend to be red orange yellow.

Batch B has no body load to the point of feeling weightless with changes in the colors of things like a greenish purple blue scheme to it. None of the fractuals.

Is this a mental thing or is it actually a difference in whats in the shrooms themself?
 
Yeah. The alkaloidal (naturally occurring psychoactive compounds) are the same but could be in varying amounts. As with any other mushroom. Psilocybin metaboloizes into psilocin in the human body which I believe could slightly alter the psychoactive experience on some level. Just my .02
 
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It would be interesting to know what enzymes de-phosphorate psilocybin- whether an inhibitor could be used to stop the process and then see if psilocybin is psychoactive....?
 
The subjective effects of psilocybe mushrooms can vary a lot from species to species (or rather sup-species to sub-species). The batch I have right now produces minimal body-load, few visuals, and is very mental and surprisingly euphoric. The last mushrooms I came across had a strong and somewhat uncomfortable body-load, and were very visual. The reason for the difference, as pointed out earlier, is the relative proportions of tryptamine alkaloids in the mushrooms.

In theory, pure psilocybin should produce identical effects as pure psilocin, because the psilocybin is metabolized into psilocin before it ever reaches the brain, although the subjective experiences of those who have tried the pure compounds do seem to show some distinctions between the two.
 
I'm pretty amazed by the differences to be honest. P. semilanceata, for me at least produces a hugely different trip to the other species I have sampled. My personal guess would be the high relative baeocystin content (one of the highest concentrations of any species, greater than P. azurenscens even...) as opposed to the the extremely low psilocin content (one of the lowest of any decently active species). I'm not really basing this on much other than that it seems logical to me that an entirely different molecule, with different 5-HT affinities, would have a greater impact than the lack of psilocin (which you are getting anyway from the dephosphorolation of psilocybin). Hopefully I will be able to sample P. cyanofibrillosa sometime in the nearish future; a species lacking in both psilocin and baeocystin. A comparison between P. cyanescens and P. azurenscens would also be very handy here, though somewhat less so as P. azurenscens is just stronger all around - fat chance I will get to try P. azurs anytime soon anyhow. Course the best way would be having all three compounds in my draw, not much chance of that either though :)

Does anyone know of any data for the active chemical concentrations of P. mexicana? This would be most awesome if such data did exist.
 
^ From wiki

All mammalian alkaline phosphatase isoenzymes except placental (PALP and SEAP) are inhibited by homoarginine and similarly all except the intestinal and placental ones are blocked by levamisole. Heating for ~2 hours at 65oC inactivated most isoenzymes except Placental isoforms (PALP and SEAP).
Click to expand...
 
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